scholarly journals Cullin-4 regulates Wingless and JNK signaling-mediated cell death in the Drosophila eye

2016 ◽  
Vol 7 (12) ◽  
pp. e2566-e2566 ◽  
Author(s):  
Meghana Tare ◽  
Ankita Sarkar ◽  
Shimpi Bedi ◽  
Madhuri Kango-Singh ◽  
Amit Singh
Keyword(s):  
Cell Death ◽  
Jnk Signaling ◽  
Cullin 4 ◽  
Drosophila Eye

scholarly journals Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway

1998 ◽  
Vol 5 (4) ◽  
pp. 262-270 ◽  
Author(s):  
Kazunobu Sawamoto ◽  
Akiko Taguchi ◽  
Yuki Hirota ◽  
Chiharu Yamada ◽  
Ming-hao Jin ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Ras Pathway ◽  
Drosophila Eye

Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye

Development ◽  
2000 ◽  
Vol 127 (16) ◽  
pp. 3619-3629 ◽  
Author(s):  
U. Weber ◽  
N. Paricio ◽  
M. Mlodzik
Keyword(s):  
Cell Fate ◽  
Genetic Interaction ◽  
Function Analysis ◽  
Loss Of Function ◽  
Planar Polarity ◽  
Jnk Signaling ◽  
Drosophila Eye ◽  
Polarity Determination ◽  
Signaling Components

Jun acts as a signal-regulated transcription factor in many cellular decisions, ranging from stress response to proliferation control and cell fate induction. Genetic interaction studies have suggested that Jun and JNK signaling are involved in Frizzled (Fz)-mediated planar polarity generation in the Drosophila eye. However, simple loss-of-function analysis of JNK signaling components did not show comparable planar polarity defects. To address the role of Jun and JNK in Fz signaling, we have used a combination of loss- and gain-of-function studies. Like Fz, Jun affects the bias between the R3/R4 photoreceptor pair that is critical for ommatidial polarity establishment. Detailed analysis of jun(−) clones reveals defects in R3 induction and planar polarity determination, whereas gain of Jun function induces the R3 fate and associated polarity phenotypes. We find also that affecting the levels of JNK signaling by either reduction or overexpression leads to planar polarity defects. Similarly, hypomorphic allelic combinations and overexpression of the negative JNK regulator Puckered causes planar polarity eye phenotypes, establishing that JNK acts in planar polarity signaling. The observation that Dl transcription in the early R3/R4 precursor cells is deregulated by Jun or Hep/JNKK activation, reminiscent of the effects seen with Fz overexpression, suggests that Jun is one of the transcription factors that mediates the effects of fz in planar polarity generation.

Pristimerin Induces Autophagy‐Mediated Cell Death in K562 Cells through the ROS/JNK Signaling Pathway

2019 ◽  
Vol 16 (8) ◽  
Author(s):  
Yingxiang Liu ◽  
Ziting Ren ◽  
Xiang Li ◽  
Jing Zhong ◽  
Yun Bi ◽  
...  
Keyword(s):  
Cell Death ◽  
Signaling Pathway ◽  
K562 Cells ◽  
Jnk Signaling ◽  
Jnk Signaling Pathway

Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells

Toxicology ◽  
2008 ◽  
Vol 246 (2-3) ◽  
pp. 234-241 ◽  
Author(s):  
Sheng-Fan Wang ◽  
Jiin-Cherng Yen ◽  
Pen-Hui Yin ◽  
Chin-Wen Chi ◽  
Hsin-Chen Lee
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Jnk Signaling

JLP-JNK signaling protects cancer cells from reactive oxygen species-induced cell death

2018 ◽  
Vol 501 (3) ◽  
pp. 724-730 ◽  
Author(s):  
Rong Li ◽  
I. Ketut Gunarta ◽  
Ryusuke Suzuki ◽  
Jambaldorj Boldbaatar ◽  
Ryota Nakazato ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Jnk Signaling

ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death

2003 ◽  
Vol 85 (1) ◽  
pp. 50-61 ◽  
Author(s):  
Krishna Pada Sarker ◽  
Kamal Krishna Biswas ◽  
Munekazu Yamakuchi ◽  
Ki-Young Lee ◽  
Teruto Hahiguchi ◽  
...  
Keyword(s):  
Cell Death ◽  
P38 Mapk ◽  
Pc12 Cell ◽  
Signaling Cascade ◽  
Jnk Signaling

scholarly journals Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Sheng-Chun Chiu ◽  
Mei-Jen Wang ◽  
Hsueh-Hui Yang ◽  
Shee-Ping Chen ◽  
Sung-Ying Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Jnk Signaling

Proapoptotic function of protein kinase CK2α" is mediated by a JNK signaling cascade

2004 ◽  
Vol 287 (1) ◽  
pp. G192-G201 ◽  
Author(s):  
Philip Hilgard ◽  
Mark J. Czaja ◽  
Guido Gerken ◽  
Richard J. Stockert
Keyword(s):  
Cell Death ◽  
Protein Kinase ◽  
Membrane Trafficking ◽  
Mutant Cell ◽  
Signaling Cascade ◽  
Dengue Virus Infection ◽  
Α Subunit ◽  
Jnk Signaling ◽  
Tnf Α ◽  
Kinase Ck2

Protein kinase CK2 (formerly casein kinase II) is a tetrameric enzyme constitutively expressed in all eurakyotic tissues that plays a significant role in the regulation of cell proliferation, malignant transformation, and apoptosis. The catalytic α-subunit of the enzyme is known to exist in three isoforms CK2α, CK2α′ and CK2α". CK2α" is highly expressed in liver compared with other tissues and is required for the normal trafficking of several hepatocellular membrane proteins. Initial studies of dengue virus infection indicated that the CK2α"-deficient membrane trafficking mutant cell line (Trf1) was resistant to virus-induced cell death compared with the parental human hepatoma (HuH)-7 hepatoma line. Expression of recombinant CK2α" in Trf1 was capable of reverting this resistant phenotype. This study was extended to TNF-α in addition to other stimuli of cell death in an attempt to uncover common death pathways that might be modulated by CK2α". Evaluation of different pathways involved in death signaling suggest that the regulation of a critical proapoptotic step in HuH-7 cells by CK2α" is mediated by a JNK signaling cascade.

scholarly journals JNK signaling in neomycin-induced vestibular hair cell death

2006 ◽  
Vol 221 (1-2) ◽  
pp. 128-135 ◽  
Author(s):  
Kazuma Sugahara ◽  
Edwin W. Rubel ◽  
Lisa L. Cunningham
Keyword(s):  
Cell Death ◽  
Hair Cell ◽  
Jnk Signaling ◽  
Hair Cell Death
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