scholarly journals Toll-like receptor 4 modulates the cochlear immune response to acoustic injury

2016 ◽  
Vol 7 (6) ◽  
pp. e2245-e2245 ◽  
Author(s):  
R R Vethanayagam ◽  
W Yang ◽  
Y Dong ◽  
B H Hu
Keyword(s):  
Immune Response ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals Variability among Macaca fascicularis in the innate immune response to Toll‐like receptor 4 (TLR4) agonists

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Charles Wayne Frevert ◽  
Renee Hukkanen ◽  
Steve Mongovin ◽  
Kay Larsen ◽  
Mike Agy ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Macaca Fascicularis ◽  
Innate Immune ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

Toll-like receptor-4 expressed on gastric pit cells may initiate innate immune response of gastric mucosa against Helicobactor pylori infection

2001 ◽  
Vol 120 (5) ◽  
pp. A59
Author(s):  
Kazuhito Rokutan ◽  
Shigetada Teshima ◽  
Tsukasa Kawahara ◽  
Tomoko Kawai ◽  
Takeshi Nikawa ◽  
...  
Keyword(s):  
Immune Response ◽  
Gastric Mucosa ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Helicobactor Pylori ◽  
Pit Cells

scholarly journals Energetics of Endotoxin Recognition in the Toll-Like Receptor 4 Innate Immune Response

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Teresa Paramo ◽  
Susana M. Tomasio ◽  
Kate L. Irvine ◽  
Clare E. Bryant ◽  
Peter J. Bond
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals Toll-Like Receptor 4 Agonistic Antibody Promotes Host Defense against Chronic Pseudomonas aeruginosa Lung Infection in Mice

2016 ◽  
Vol 84 (7) ◽  
pp. 1986-1993 ◽  
Author(s):  
Shigeki Nakamura ◽  
Naoki Iwanaga ◽  
Masafumi Seki ◽  
Kenji Fukudome ◽  
Kazuhiro Oshima ◽  
...  
Keyword(s):  
Immune Response ◽  
Pseudomonas Aeruginosa ◽  
Neutrophil Recruitment ◽  
Dependent Manner ◽  
Bacterial Clearance ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Content Type ◽  
Opsonophagocytic Killing

Chronic lower respiratory tract infection withPseudomonas aeruginosais difficult to treat due to enhanced antibiotic resistance and decreased efficacy of drug delivery to destroyed lung tissue. To determine the potential for restorative immunomodulation therapies, we evaluated the effect of Toll-like receptor 4 (TLR4) stimulation on the host immune response toPseudomonasinfection in mice. We implanted sterile plastic tubes precoated withP. aeruginosain the bronchi of mice, administered the TLR4/MD2 agonistic monoclonal antibody UT12 intraperitoneally every week, and subsequently analyzed the numbers of viable bacteria and inflammatory cells and the levels of cytokines. We also performed flow cytometry-based phagocytosis and opsonophagocytic killing assaysin vitrousing UT12-treated murine peritoneal neutrophils. UT12-treated mice showed significantly enhanced bacterial clearance, increased numbers of Ly6G+neutrophils, and increased concentrations of macrophage inflammatory protein 2 (MIP-2) in the lungs (P< 0.05). Depletion of CD4+T cells eliminated the ability of the UT12 treatment to improve bacterial clearance and promote neutrophil recruitment and MIP-2 production. Additionally, UT12-pretreated peritoneal neutrophils exhibited increased opsonophagocytic killing activity via activation of the serine protease pathway, specifically neutrophil elastase activity, in a TLR4-dependent manner. These data indicated that UT12 administration significantly augmented the innate immune response against chronic bacterial infection, in part by promoting neutrophil recruitment and bactericidal function.

scholarly journals Mycobacterium abscessus MAB2560 induces maturation of dendritic cells via Toll-like receptor 4 and drives Th1 immune response

BMB Reports ◽  
2014 ◽  
Vol 47 (9) ◽  
pp. 512-517 ◽  
Author(s):  
Su Jung Lee ◽  
Sung Jae Shin ◽  
Seung Jun Lee ◽  
Moon Hee Lee ◽  
Tae Heung Kang ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Mycobacterium Abscessus ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Th1 Immune Response

scholarly journals Trichinella spiralis: impact on the expression of Toll-like receptor 4 (TLR4) gene during the intestinal phase of experimental trichinellosis

2018 ◽  
Vol 62 (4) ◽  
pp. 493-496
Author(s):  
Agnieszka Wojtkowiak-Giera ◽  
Elżbieta Wandurska-Nowak ◽  
Monika Derda ◽  
Wiesława Jankowska ◽  
Paweł P. Jagodziński ◽  
...  
Keyword(s):  
Immune Response ◽  
Trichinella Spiralis ◽  
Mrna Level ◽  
Innate Immune ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Intestinal Phase ◽  
Strong Positive Reaction ◽  
Tlr4 Gene ◽  
Rapid Activation

AbstractIntroduction: Toll-like receptors (TLRs) play a key role in the rapid activation of the innate immune response to a variety of pathogens. The aim of this study was to evaluate the effect of Trichinella spiralis infection on the level of expression of the tlr4 gene in mouse intestines during the intestinal phase of experimental trichinellosis.Material and Methods: The experimental material consisted of the small and large intestines of BALB/c mice infected with Trichinella spiralis sampled at 4, 8, and 16 days post infection (dpi).Results: A statistically significant increase was demonstrated in the tlr4 mRNA level isolated from the infected mice jejunum at 4, 8, and 16 dpi over the uninfected control. Moreover, at 4, 8, and 16 dpi in the jejunum of infected mice, a strong positive reaction for the presence of TLR4 protein compared with that of uninfected mice was observed.Conclusion: Infection with T. spiralis changes the expression of the tlr4 gene in the small intestine of the mouse host.

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