scholarly journals Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8+ T-cell priming in vitro by Mer tyrosine kinase-dependent signaling

2015 ◽  
Vol 6 (12) ◽  
pp. e2018-e2018 ◽  
Author(s):  
F L Ribeiro-Gomes ◽  
A Romano ◽  
S Lee ◽  
E Roffê ◽  
N C Peters ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Leishmania Major ◽  
Apoptotic Cell ◽  
Cd8 T Cell ◽  
Apoptotic Cell Clearance ◽  
Cell Clearance ◽  
T Cell Priming ◽  
Mer Tyrosine Kinase

scholarly journals Human conventional CD1c+ Dendritic Cells produce IL-12 and induce potent CD8+ T cell priming

2013 ◽  
Vol 4 ◽  
Author(s):  
Nizzoli Giulia ◽  
Weick Anja ◽  
Krietsch Jana ◽  
Steinfelder Svenja ◽  
Facciotti Federica ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Priming

scholarly journals Persistence of apoptotic cells without autoimmune disease or inflammation in CD14−/− mice

2004 ◽  
Vol 167 (6) ◽  
pp. 1161-1170 ◽  
Author(s):  
Andrew Devitt ◽  
Kate G. Parker ◽  
Carol Anne Ogden ◽  
Ceri Oldreive ◽  
Michael F. Clay ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Apoptotic Cell ◽  
Apoptotic Cells ◽  
Autoantibody Production ◽  
Apoptotic Cell Clearance ◽  
Cell Clearance ◽  
Surface Receptor ◽  
Anti Inflammatory

Interaction of macrophages with apoptotic cells involves multiple steps including recognition, tethering, phagocytosis, and anti-inflammatory macrophage responses. Defective apoptotic cell clearance is associated with pathogenesis of autoimmune disease. CD14 is a surface receptor that functions in vitro in the removal of apoptotic cells by human and murine macrophages, but its mechanism of action has not been defined. Here, we demonstrate that CD14 functions as a macrophage tethering receptor for apoptotic cells. Significantly, CD14−/− macrophages in vivo are defective in clearing apoptotic cells in multiple tissues, suggesting a broad role for CD14 in the clearance process. However, the resultant persistence of apoptotic cells does not lead to inflammation or increased autoantibody production, most likely because, as we show, CD14−/− macrophages retain the ability to generate anti-inflammatory signals in response to apoptotic cells. We conclude that CD14 plays a broad tethering role in apoptotic cell clearance in vivo and that apoptotic cells can persist in the absence of proinflammatory consequences.

scholarly journals 5-Hydroxytryptamine Modulates Migration, Cytokine and Chemokine Release and T-Cell Priming Capacity of Dendritic Cells In Vitro and In Vivo

PLoS ONE ◽  
2009 ◽  
Vol 4 (7) ◽  
pp. e6453 ◽  
Author(s):  
Tobias Müller ◽  
Thorsten Dürk ◽  
Britta Blumenthal ◽  
Melanie Grimm ◽  
Sanja Cicko ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Priming

scholarly journals CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming

2008 ◽  
Vol 205 (11) ◽  
pp. 2561-2574 ◽  
Author(s):  
Alfonso Martín-Fontecha ◽  
Dirk Baumjohann ◽  
Greta Guarda ◽  
Andrea Reboldi ◽  
Miroslav Hons ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Lymph Nodes ◽  
Memory T Cells ◽  
Effector Memory ◽  
High Endothelial Venules ◽  
T Cell Priming ◽  
Dc Maturation

There is growing evidence that the maturation state of dendritic cells (DCs) is a critical parameter determining the balance between tolerance and immunity. We report that mouse CD4+ effector memory T (TEM) cells, but not naive or central memory T cells, constitutively expressed CD40L at levels sufficient to induce DC maturation in vitro and in vivo in the absence of antigenic stimulation. CD4+ TEM cells were excluded from resting lymph nodes but migrated in a CD62P-dependent fashion into reactive lymph nodes that were induced to express CD62P, in a transient or sustained fashion, on high endothelial venules. Trafficking of CD4+ TEM cells into chronic reactive lymph nodes maintained resident DCs in a mature state and promoted naive T cell responses and experimental autoimmune encephalomyelitis (EAE) to antigens administered in the absence of adjuvants. Antibodies to CD62P, which blocked CD4+ TEM cell migration into reactive lymph nodes, inhibited DC maturation, T cell priming, and induction of EAE. These results show that TEM cells can behave as endogenous adjuvants and suggest a mechanistic link between lymphocyte traffic in lymph nodes and induction of autoimmunity.

scholarly journals Correction: A Human Trypanosome Suppresses CD8+ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4+ Foxp3+ T Cells

2016 ◽  
Vol 12 (7) ◽  
pp. e1005771
Author(s):  
Jonatan Ersching ◽  
Alexandre Salgado Basso ◽  
Vera Lúcia Garcia Calich ◽  
Karina Ramalho Bortoluci ◽  
Maurício M. Rodrigues
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Priming

scholarly journals Diacylglycerol Lipase-β Is Required for TNF-α Response but Not CD8+ T Cell Priming Capacity of Dendritic Cells

2019 ◽  
Vol 26 (7) ◽  
pp. 1036-1041.e3 ◽  
Author(s):  
Myungsun Shin ◽  
Andrew Buckner ◽  
Jessica Prince ◽  
Timothy N.J. Bullock ◽  
Ku-Lung Hsu
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cd8 T Cell ◽  
Diacylglycerol Lipase ◽  
Tnf Α ◽  
T Cell Priming
Sign in / Sign up

Export Citation Format

Share Document