scholarly journals Intrinsic hypoxia sensitivity of the cytomegalovirus promoter

2015 ◽  
Vol 6 (10) ◽  
pp. e1905-e1905 ◽  
Author(s):  
K Wendland ◽  
M Thielke ◽  
A Meisel ◽  
P Mergenthaler
Keyword(s):  
Cytomegalovirus Promoter

scholarly journals Single Cell Analysis of RNA-mediated Histone H3.3 Recruitment to a Cytomegalovirus Promoter-regulated Transcription Site

2013 ◽  
Vol 288 (27) ◽  
pp. 19882-19899 ◽  
Author(s):  
Alyshia Newhart ◽  
Ilona U. Rafalska-Metcalf ◽  
Tian Yang ◽  
Lucy M. Joo ◽  
Sara Lawrence Powers ◽  
...  
Keyword(s):  
Single Cell ◽  
Single Cell Analysis ◽  
Cell Analysis ◽  
Cytomegalovirus Promoter ◽  
Transcription Site ◽  
Histone H3.3

HIV-1 Vpr suppresses the cytomegalovirus promoter in a CRL4(DCAF1) E3 ligase independent manner

2015 ◽  
Vol 459 (2) ◽  
pp. 214-219 ◽  
Author(s):  
Xianjun Liu ◽  
Haoran Guo ◽  
Hong Wang ◽  
Richard Markham ◽  
Wei Wei ◽  
...  
Keyword(s):  
E3 Ligase ◽  
Independent Manner ◽  
Cytomegalovirus Promoter ◽  
Hiv 1

scholarly journals Irradiation, Cisplatin, and 5-Azacytidine Upregulate Cytomegalovirus Promoter in Tumors and Muscles: Implementation of Non-invasive Fluorescence Imaging

2010 ◽  
Vol 13 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Urska Kamensek ◽  
Gregor Sersa ◽  
Suzana Vidic ◽  
Gregor Tevz ◽  
Simona Kranjc ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Cytomegalovirus Promoter ◽  
Non Invasive

scholarly journals Cell type-specific activation of the cytomegalovirus promoter by dimethylsulfoxide and 5-Aza-2'-deoxycytidine

2008 ◽  
Vol 40 (9) ◽  
pp. 1944-1955 ◽  
Author(s):  
Prakash Radhakrishnan ◽  
Hesham Basma ◽  
David Klinkebiel ◽  
Judith Christman ◽  
Pi-Wan Cheng
Keyword(s):  
Cell Type ◽  
Cytomegalovirus Promoter ◽  
Cell Type Specific

scholarly journals Sp100A promotes chromatin decondensation at a cytomegalovirus-promoter–regulated transcription site

2013 ◽  
Vol 24 (9) ◽  
pp. 1454-1468 ◽  
Author(s):  
Alyshia Newhart ◽  
Dmitri G. Negorev ◽  
Ilona U. Rafalska-Metcalf ◽  
Tian Yang ◽  
Gerd G. Maul ◽  
...  
Keyword(s):  
Transcriptional Repression ◽  
Single Cells ◽  
Single Copy ◽  
Nuclear Bodies ◽  
Chromatin Decondensation ◽  
Cytomegalovirus Promoter ◽  
Transcription Site ◽  
Sand Domain ◽  
Nuclear Structures ◽  
Simplex Virus

Promyelocytic leukemia nuclear bodies (PML-NBs)/nuclear domain 10s (ND10s) are nuclear structures that contain many transcriptional and chromatin regulatory factors. One of these, Sp100, is expressed from a single-copy gene and spliced into four isoforms (A, B, C, and HMG), which differentially regulate transcription. Here we evaluate Sp100 function in single cells using an inducible cytomegalovirus-promoter–regulated transgene, visualized as a chromatinized transcription site. Sp100A is the isoform most strongly recruited to the transgene array, and it significantly increases chromatin decondensation. However, Sp100A cannot overcome Daxx- and α-thalassemia mental retardation, X-linked (ATRX)–mediated transcriptional repression, which indicates that PML-NB/ND10 factors function within a regulatory hierarchy. Sp100A increases and Sp100B, which contains a SAND domain, decreases acetyl-lysine regulatory factor levels at activated sites, suggesting that Sp100 isoforms differentially regulate transcription by modulating lysine acetylation. In contrast to Daxx, ATRX, and PML, Sp100 is recruited to activated arrays in cells expressing the herpes simplex virus type 1 E3 ubiquitin ligase, ICP0, which degrades all Sp100 isoforms except unsumoylated Sp100A. The recruitment Sp100A(K297R), which cannot be sumoylated, further suggests that sumoylation plays an important role in regulating Sp100 isoform levels at transcription sites. This study provides insight into the ways in which viruses may modulate Sp100 to promote their replication cycles.

Age-dependent alteration of transgene expression and cytomegalovirus promoter methylation in transgenic cloned and recloned dogs

2015 ◽  
Vol 82 (5) ◽  
pp. 330-331 ◽  
Author(s):  
Hyun Ju Oh ◽  
Geon A Kim ◽  
Sang Ho Rhee ◽  
Ming Jung Kim ◽  
Islam M. Saadeldin ◽  
...  
Keyword(s):  
Promoter Methylation ◽  
Transgene Expression ◽  
Cytomegalovirus Promoter ◽  
Age Dependent
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