scholarly journals Neuroprotective effect of osmotin against ethanol-induced apoptotic neurodegeneration in the developing rat brain

2014 ◽  
Vol 5 (3) ◽  
pp. e1150-e1150 ◽  
Author(s):  
M I Naseer ◽  
I Ullah ◽  
M L Narasimhan ◽  
H Y Lee ◽  
R A Bressan ◽  
...  
Keyword(s):  
Rat Brain ◽  
Neuroprotective Effect ◽  
Developing Rat ◽  
Apoptotic Neurodegeneration

Protective effect of pyruvate against ethanol-induced apoptotic neurodegeneration in the developing rat brain

2011 ◽  
Vol 61 (8) ◽  
pp. 1248-1255 ◽  
Author(s):  
Najeeb Ullah ◽  
Muhammad Imran Naseer ◽  
Ikram Ullah ◽  
Hae Young Lee ◽  
Phil Ok Koh ◽  
...  
Keyword(s):  
Protective Effect ◽  
Rat Brain ◽  
Developing Rat ◽  
Apoptotic Neurodegeneration

The Evaluation of Sevoflurane-Induced Apoptotic Neurodegeneration with MicroPET Using [18F]-DFNSH in the Developing Rat Brain

2013 ◽  
Vol 2 ◽  
pp. 1-7 ◽  
Author(s):  
Shuliang Liu ◽  
Merle G. Paule ◽  
Xuan Zhang ◽  
Glenn D. Newport ◽  
Scott M. Apana ◽  
...  
Keyword(s):  
Rat Brain ◽  
Developing Rat ◽  
Apoptotic Neurodegeneration

Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain

2006 ◽  
Vol 23 (Supplement 37) ◽  
pp. 98
Author(s):  
J. Yon ◽  
O. Kim ◽  
S. Lee ◽  
K. Hong ◽  
V. Todorovic
Keyword(s):  
Rat Brain ◽  
Developing Rat ◽  
Apoptotic Neurodegeneration

Pathways Leading to Apoptotic Neurodegeneration Following Trauma to the Developing Rat Brain

2002 ◽  
Vol 11 (2) ◽  
pp. 231-245 ◽  
Author(s):  
Ursula Felderhoff-Mueser ◽  
Marco Sifringer ◽  
Stefanie Pesditschek ◽  
Heike Kuckuck ◽  
Axel Moysich ◽  
...  
Keyword(s):  
Rat Brain ◽  
Developing Rat ◽  
Apoptotic Neurodegeneration

scholarly journals Spatiotemporal evolution of apoptotic neurodegeneration following traumatic injury to the developing rat brain

2006 ◽  
Vol 1107 (1) ◽  
pp. 70-81 ◽  
Author(s):  
Philip V. Bayly ◽  
Krikor T. Dikranian ◽  
Erin E. Black ◽  
Chainllie Young ◽  
Yue-Qin Qin ◽  
...  
Keyword(s):  
Rat Brain ◽  
Traumatic Injury ◽  
Spatiotemporal Evolution ◽  
Developing Rat ◽  
Apoptotic Neurodegeneration

scholarly journals Role of NR2B/ERK signaling in the neuroprotective effect of dexmedetomidine against sevoflurane induced neurological dysfunction in the developing rat brain

2020 ◽  
Author(s):  
Guohua Li ◽  
Yanwu Jin ◽  
Fang Cao ◽  
Dawei Wang ◽  
Limin Zhou
Keyword(s):  
Rat Brain ◽  
Escape Latency ◽  
Neuroprotective Effect ◽  
Memory Function ◽  
Neurological Impairment ◽  
Neurological Dysfunction ◽  
Erk Signaling ◽  
Sprague Dawley ◽  
Protein Levels ◽  
Developing Rat

Abstract Background Dexmedetomidine (DEX) is a new-generation, and has been widely applied in clinic. The present study confirmed the protective effect of DEX on sevoflurane induced learning and cognitive impairment and examined its underlying mechanism. Methods Sprague-Dawley rats were exposed to 0.85% sevoflurane for 6 h and injected with DEX in different dose. Morris water maze (MWM) test was performed to evaluate the learning and memory function of rats. Western blot was used for the measurement of protein levels. Results MWM results indicated that sevoflurane treatment increased the escape latency but reduced the time spent in original quadrant of rats. The protein levels of NR2B, phosphorylated ERK were significantly influenced by sevoflurane. Ifenprodil administration alleviated sevoflurane induced neurological impairment. DEX treatment reversed the effect of sevoflurane on both escape latency and time in original quadrant in a dose manner, and pretreatment with 75 µg/kg DEX had the most dramatic effect. DEX regulates the NR2B/ERK signaling in sevoflurane treated rats. Conclusion NR2B/ERK signaling is involved in sevoflurane induced neurological impairment. DEX may protect against sevoflurane induced neurological dysfunction in the developing rat brain via regulating the NR2B/ERK signaling.

Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain

1999 ◽  
Vol 408 (4) ◽  
pp. 461-476 ◽  
Author(s):  
M.J. Ishimaru ◽  
C. Ikonomidou ◽  
T.I. Tenkova ◽  
T.C. Der ◽  
K. Dikranian ◽  
...  
Keyword(s):  
Rat Brain ◽  
Developing Rat ◽  
Apoptotic Neurodegeneration

Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain

2006 ◽  
Vol 21 (3) ◽  
pp. 522-530 ◽  
Author(s):  
Jun-Heum Yon ◽  
Lisa B. Carter ◽  
Russel J. Reiter ◽  
Vesna Jevtovic-Todorovic
Keyword(s):  
Rat Brain ◽  
Developing Rat ◽  
Apoptotic Neurodegeneration

scholarly journals Nicotinamide Inhibits Alkylating Agent-Induced Apoptotic Neurodegeneration in the Developing Rat Brain

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e27093 ◽  
Author(s):  
Najeeb Ullah ◽  
Hae Young Lee ◽  
Muhammad Imran Naseer ◽  
Ikram Ullah ◽  
Joo Won Suh ◽  
...  
Keyword(s):  
Rat Brain ◽  
Alkylating Agent ◽  
Developing Rat ◽  
Apoptotic Neurodegeneration
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