scholarly journals Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation

2014 ◽  
Vol 5 (10) ◽  
pp. e1482-e1482 ◽  
Author(s):  
H Huang ◽  
K Shah ◽  
N A Bradbury ◽  
C Li ◽  
C White
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Cell Migration ◽  
Cancer Cell ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cancer Cell Migration ◽  
Lung Cancer Cell

scholarly journals Regulation of Lung Cancer Cell Migration and Invasion by Reactive Oxygen Species and Caveolin-1

2010 ◽  
Vol 285 (50) ◽  
pp. 38832-38840 ◽  
Author(s):  
Sudjit Luanpitpong ◽  
Siera Jo Talbott ◽  
Yon Rojanasakul ◽  
Ubonthip Nimmannit ◽  
Varisa Pongrakhananon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Cell Migration ◽  
Cancer Cell ◽  
Migration And Invasion ◽  
Oxygen Species ◽  
Cancer Cell Migration ◽  
Lung Cancer Cell ◽  
Cell Migration And Invasion ◽  
Caveolin 1

scholarly journals Moscatilin Inhibits Lung Cancer Cell Motility and Invasion via Suppression of Endogenous Reactive Oxygen Species

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Akkarawut Kowitdamrong ◽  
Pithi Chanvorachote ◽  
Boonchoo Sritularak ◽  
Varisa Pongrakhananon
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Cell Migration ◽  
Cell Motility ◽  
Cancer Cell ◽  
Migration And Invasion ◽  
Oxygen Species ◽  
Lung Cancer Cell ◽  
Cancer Cell Motility ◽  
Endogenous Reactive Oxygen Species

Lung cancer is the leading cause of death among cancer patients worldwide, and most of them have died from metastasis. Migration and invasion are prerequisite processes associated with high metastasis potential in cancers. Moscatilin, a bibenzyl derivative isolated from the Thai orchidDendrobium pulchellum, has been shown to have anticancer effect against numerous cancer cell lines. However, little is known regarding the effect of moscatilin on cancer cell migration and invasion. The present study demonstrates that nontoxic concentrations of moscatilin were able to inhibit human nonsmall cell lung cancer H23 cell migration and invasion. The inhibitory effect of moscatilin was associated with an attenuation of endogenous reactive oxygen species (ROS), in which hydroxyl radical (OH∙) was identified as a dominant species in the suppression of filopodia formation. Western blot analysis also revealed that moscatilin downregulated activated focal adhesion kinase (phosphorylated FAK, Tyr 397) and activated ATP-dependent tyrosine kinase (phosphorylated Akt, Ser 473), whereas their parental counterparts were not detectable changed. In conclusion, our results indicate the novel molecular basis of moscalitin-inhibiting lung cancer cell motility and invasion and demonstrate a promising antimetastatic potential of such an agent for lung cancer therapy.

Curcumin sensitizes non-small cell lung cancer cell anoikis through reactive oxygen species-mediated Bcl-2 downregulation

APOPTOSIS ◽  
2010 ◽  
Vol 15 (5) ◽  
pp. 574-585 ◽  
Author(s):  
Varisa Pongrakhananon ◽  
Ubonthip Nimmannit ◽  
Sudjit Luanpitpong ◽  
Yon Rojanasakul ◽  
Pithi Chanvorachote
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Reactive Oxygen ◽  
Small Cell ◽  
Oxygen Species ◽  
Lung Cancer Cell ◽  
Small Cell Lung
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