scholarly journals Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells

2012 ◽  
Vol 3 (4) ◽  
pp. e301-e301 ◽  
Author(s):  
R Elanchezhian ◽  
P Palsamy ◽  
C J Madson ◽  
M L Mulhern ◽  
D W Lynch ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Epithelial Cells ◽  
Unfolded Protein Response ◽  
Reactive Oxygen ◽  
Lens Epithelial Cells ◽  
Oxygen Species ◽  
Unfolded Protein ◽  
Hypoxic Conditions ◽  
Low Glucose ◽  
Protein Response

scholarly journals Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos

2017 ◽  
Vol 18 (1) ◽  
pp. 1 ◽  
Author(s):  
Ihsan Ali ◽  
Syed Zahid Ali Shah ◽  
Yi Jin ◽  
Zhong-Shu Li ◽  
Obaid Ullah ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Unfolded Protein Response ◽  
Reactive Oxygen ◽  
Preimplantation Embryos ◽  
Oxygen Species ◽  
Unfolded Protein ◽  
Protein Response

scholarly journals Involvement of Selective Reactive Oxygen Species Upstream of Proapoptotic Branches of Unfolded Protein Response

2007 ◽  
Vol 283 (7) ◽  
pp. 4252-4260 ◽  
Author(s):  
Makiko Yokouchi ◽  
Nobuhiko Hiramatsu ◽  
Kunihiro Hayakawa ◽  
Maro Okamura ◽  
Shuqi Du ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Unfolded Protein Response ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Unfolded Protein ◽  
Protein Response

scholarly journals Oxidative stress-induced impairment of trophoblast function causes preeclampsia through the unfolded protein response pathway

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Indrani Mukherjee ◽  
Ruby Dhar ◽  
Sunil Singh ◽  
Jai Bhagwan Sharma ◽  
Tapas Chandra Nag ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Unfolded Protein Response ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Trophoblast Cells ◽  
Variable Expression ◽  
Unfolded Protein ◽  
Cell Functions ◽  
Protein Response

AbstractPre-eclampsia (PE) is a pregnancy-specific disorder, characterized by hypertension and proteinuria. In PE, trophoblasts mediated inadequate remodeling of uterine spiral arteries seem to interrupt uteroplacental blood flow, one of the hallmarks in the early onset of PE (EO-PE). This, in turn, results in placental ischemia–reperfusion injury during hypoxia and reoxygenation episodes, leading to the generation of reactive oxygen species (ROS) and oxidative stress (OS). But still it is debatable if OS is a cause or consequence of PE. In this present study, we have investigated the effects of OS on PE placentae and trophoblast cell functions using BeWo and HTR8/SVneo cell lines. PE placental tissues showed abnormal ultrastructure, high level of reactive oxygen species (ROS) with altered unfolded protein responses (UPR) in compare with term placental tissues. Similar to PE placentae, during OS induction, the trophoblast cells showed altered invasion and migration properties with significantly variable expression of differentiation and invasion markers, e.g., syncytin and MMPs. The effect was rescued by antioxidant, N-acetyl cysteine, thereby implying a ROS-specific effect and in the trophoblast cells, OS triggers UPR pathway through IRE1α-XBP1 axis. Taken together, these findings highlight the harmful effect of unfolded protein response, which was induced due to OS on trophoblast cells and deformed invasion and differentiation programme and can be extended further to clinical settings to identify clinically approved antioxidants during pregnancy as a therapeutic measure to reduce the onset of PE.

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