scholarly journals Distinct roles for the cellular inhibitors of apoptosis proteins 1 and 2

2011 ◽  
Vol 2 (3) ◽  
pp. e135-e135 ◽  
Author(s):  
T E Graber ◽  
M Holcik
Keyword(s):  
Inhibitors Of Apoptosis ◽  
Inhibitors Of Apoptosis Proteins ◽  
Cellular Inhibitors ◽  
Apoptosis Proteins

scholarly journals The Opposing Roles of Cellular Inhibitor of Apoptosis Proteins in Cancer

ISRN Oncology ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
R. Lau ◽  
M. A. C. Pratt
Keyword(s):  
Inhibitor Of Apoptosis ◽  
Inhibitors Of Apoptosis ◽  
Inhibitor Of Apoptosis Protein ◽  
Hematopoietic Malignancies ◽  
Constitutive Activation ◽  
Apoptosis Protein ◽  
Inhibitors Of Apoptosis Proteins ◽  
Cellular Inhibitors ◽  
And Function ◽  
Apoptosis Proteins

Cellular inhibitors of apoptosis proteins 1 and 2 (cIAP1/2) are members of the inhibitor of apoptosis protein (IAP) family that has been implicated in the pathology of human cancers due to their overexpression and function as blockers of cell death in various cancers. As a result, small molecule IAP antagonists have been developed and are currently under clinical evaluation for potential therapeutic use. In contrast, recent evidence has indicated a tumour-suppressing role for the cIAPs. Mutations in or loss of cIAPs have been identified as molecular lesions that contribute to constitutive activation of NF-κB in hematopoietic malignancies. These studies reveal a context-dependent role for the cIAPs wherein both their overexpression and loss may contribute to tumourigenesis.

scholarly journals Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the Inflammasome

Immunity ◽  
2011 ◽  
Vol 35 (6) ◽  
pp. 897-907 ◽  
Author(s):  
Katherine Labbé ◽  
Christian R. McIntire ◽  
Karine Doiron ◽  
Philippe M. Leblanc ◽  
Maya Saleh
Keyword(s):  
Inhibitors Of Apoptosis ◽  
Caspase 1 ◽  
Inhibitors Of Apoptosis Proteins ◽  
Cellular Inhibitors ◽  
Apoptosis Proteins

Recent Advances on Inhibitors of Apoptosis Proteins (IAP) Particularly with Reference to Patents

2017 ◽  
pp. 271-296
Author(s):  
Riyaz Syed ◽  
Prema L. Mallipeddi ◽  
Syed Mohammed Ali Hussaini ◽  
Rahul V. Patel ◽  
A. Prasanth Saraswati ◽  
...  
Keyword(s):  
Inhibitors Of Apoptosis ◽  
Recent Advances ◽  
Inhibitors Of Apoptosis Proteins ◽  
Apoptosis Proteins

Inhibitors of Apoptosis Proteins

2003 ◽  
pp. 29-46
Author(s):  
Peter Liston ◽  
Wai Gin Fong ◽  
Robert G. Korneluk
Keyword(s):  
Inhibitors Of Apoptosis ◽  
Inhibitors Of Apoptosis Proteins ◽  
Apoptosis Proteins

Inhibitors of Apoptosis Proteins Expression and Their Prognostic Significance in Colorectal Carcinoma

2011 ◽  
Vol 45 (4) ◽  
pp. 397
Author(s):  
Kyung-Hwa Lee ◽  
Soong Lee ◽  
Hyeon-Min Lee ◽  
Seung-Chul Back ◽  
Sung-Bum Cho ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Prognostic Significance ◽  
Inhibitors Of Apoptosis ◽  
Inhibitors Of Apoptosis Proteins ◽  
Apoptosis Proteins

Synthesis, molecular docking, and apoptogenic efficacy of novel N-heterocycle analogs to target B-cell lymphoma 2/X-linked inhibitors of apoptosis proteins to regress melanoma

2019 ◽  
Vol 28 (8) ◽  
pp. 1132-1160 ◽  
Author(s):  
Zabiulla Zabiulla ◽  
Vikas H. Malojirao ◽  
Yasser Hussein Eissa Mohammed ◽  
Prabhu Thirusangu ◽  
B. T. Prabhakar ◽  
...  
Keyword(s):  
Molecular Docking ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Inhibitors Of Apoptosis ◽  
Inhibitors Of Apoptosis Proteins ◽  
Apoptosis Proteins

scholarly journals Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)

APOPTOSIS ◽  
2017 ◽  
Vol 22 (7) ◽  
pp. 898-919 ◽  
Author(s):  
Rama Rathore ◽  
Jennifer E. McCallum ◽  
Elizabeth Varghese ◽  
Ana-Maria Florea ◽  
Dietrich Büsselberg
Keyword(s):  
Drug Resistance ◽  
Inhibitors Of Apoptosis ◽  
Chemotherapy Drug ◽  
Inhibitors Of Apoptosis Proteins ◽  
Apoptosis Proteins
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