scholarly journals Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death

2017 ◽  
Vol 24 (9) ◽  
pp. 1518-1529 ◽  
Author(s):  
Morgane Louessard ◽  
Isabelle Bardou ◽  
Eloïse Lemarchand ◽  
Audrey M Thiebaut ◽  
Jérôme Parcq ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cell Surface ◽  
Neuronal Death ◽  
Cell Surface Grp78

Protective effect of S-allyl-l-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain

Amino Acids ◽  
2013 ◽  
Vol 46 (2) ◽  
pp. 385-393 ◽  
Author(s):  
Toru Imai ◽  
Yasuhiro Kosuge ◽  
Kaori Endo-Umeda ◽  
Hiroko Miyagishi ◽  
Kumiko Ishige ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protective Effect ◽  
Neuronal Death

scholarly journals The Endoplasmic Reticulum Stress Sensor, ATF6α, Protects against Neurotoxin-induced Dopaminergic Neuronal Death

2010 ◽  
Vol 286 (10) ◽  
pp. 7947-7957 ◽  
Author(s):  
Naohiro Egawa ◽  
Keisuke Yamamoto ◽  
Haruhisa Inoue ◽  
Rie Hikawa ◽  
Katsunori Nishi ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Neuronal Death ◽  
Stress Sensor

scholarly journals CHIP/STUB1 Ubiquitin Ligase Functions as a Negative Regulator of ErbB2 by Promoting Its Early Post-Biosynthesis Degradation

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 3936
Author(s):  
Haitao Luan ◽  
Tameka A. Bailey ◽  
Robert J. Clubb ◽  
Bhopal C. Mohapatra ◽  
Aaqib M. Bhat ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cell Surface ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Surface Display ◽  
Combined Treatment ◽  
Negative Regulator ◽  
Breast Cancers

Overexpression of the epidermal growth factor receptor (EGFR) family member ErbB2 (HER2) drives oncogenesis in up to 25% of invasive breast cancers. ErbB2 expression at the cell surface is required for oncogenesis but mechanisms that ensure the optimal cell surface display of overexpressed ErbB2 following its biosynthesis in the endoplasmic reticulum are poorly understood. ErbB2 is dependent on continuous association with HSP90 molecular chaperone for its stability and function as an oncogenic driver. Here, we use knockdown and overexpression studies to show that the HSP90/HSC70-interacting negative co-chaperone CHIP (C-terminus of HSC70-Interacting protein)/STUB1 (STIP1-homologous U-Box containing protein 1) targets the newly synthesized, HSP90/HSC70-associated, ErbB2 for ubiquitin/proteasome-dependent degradation in the endoplasmic reticulum and Golgi, thus identifying a novel mechanism that negatively regulates cell surface ErbB2 levels in breast cancer cells, consistent with frequent loss of CHIP expression previously reported in ErbB2-overexpressing breast cancers. ErbB2-overexpressing breast cancer cells with low CHIP expression exhibited higher endoplasmic reticulum stress inducibility. Accordingly, the endoplasmic reticulum stress-inducing anticancer drug Bortezomib combined with ErbB2-targeted humanized antibody Trastuzumab showed synergistic inhibition of ErbB2-overexpressing breast cancer cell proliferation. Our findings reveal new insights into mechanisms that control the surface expression of overexpressed ErbB2 and suggest that reduced CHIP expression may specify ErbB2-overexpressing breast cancers suitable for combined treatment with Trastuzumab and ER stress inducing agents.

scholarly journals Binding of Anti-GRP78 Autoantibodies to Cell Surface GRP78 Increases Tissue Factor Procoagulant Activity via the Release of Calcium from Endoplasmic Reticulum Stores

2010 ◽  
Vol 285 (37) ◽  
pp. 28912-28923 ◽  
Author(s):  
Ali A. Al-Hashimi ◽  
Jennifer Caldwell ◽  
Mario Gonzalez-Gronow ◽  
Salvatore V. Pizzo ◽  
Danya Aboumrad ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Surface ◽  
Tissue Factor ◽  
Procoagulant Activity ◽  
Cell Surface Grp78

Endoplasmic reticulum stress and neuronal death

2004 ◽  
Vol 28 (1-2) ◽  
pp. 49-50 ◽  
Author(s):  
Kazunori Imaizumi ◽  
Masaya Tohyama
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Neuronal Death

scholarly journals Ethanol promotes endoplasmic reticulum stress-induced neuronal death: Involvement of oxidative stress

2008 ◽  
Vol 86 (4) ◽  
pp. 937-946 ◽  
Author(s):  
Gang Chen ◽  
Cuiling Ma ◽  
Kimberly A. Bower ◽  
Xianglin Shi ◽  
Zunji Ke ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Neuronal Death
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