scholarly journals Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death

2016 ◽  
Vol 24 (2) ◽  
pp. 238-250 ◽  
Author(s):  
Mi-Hyeon You ◽  
Byeong Mo Kim ◽  
Chun-Hau Chen ◽  
Michael J Begley ◽  
Lewis C Cantley ◽  
...  
Keyword(s):  
Cell Death ◽  
Protein Kinase ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Death Associated Protein Kinase

scholarly journals Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease

2019 ◽  
Vol 20 (13) ◽  
pp. 3131 ◽  
Author(s):  
Nami Kim ◽  
Dongmei Chen ◽  
Xiao Zhen Zhou ◽  
Tae Ho Lee
Keyword(s):  
Cell Death ◽  
Protein Kinase ◽  
Neurodegenerative Diseases ◽  
Molecular Mechanisms ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Biological Processes ◽  
Death Associated Protein Kinase ◽  
The Brain

Regulated neuronal cell death plays an essential role in biological processes in normal physiology, including the development of the nervous system. However, the deregulation of neuronal apoptosis by various factors leads to neurodegenerative diseases such as ischemic stroke and Alzheimer’s disease (AD). Death-associated protein kinase 1 (DAPK1) is a calcium/calmodulin (Ca2+/CaM)-dependent serine/threonine (Ser/Thr) protein kinase that activates death signaling and regulates apoptotic neuronal cell death. Although DAPK1 is tightly regulated under physiological conditions, DAPK1 deregulation in the brain contributes to the development of neurological disorders. In this review, we describe the molecular mechanisms of DAPK1 regulation in neurons under various stresses. We also discuss the role of DAPK1 signaling in the phosphorylation-dependent and phosphorylation-independent regulation of its downstream targets in neuronal cell death. Moreover, we focus on the major impact of DAPK1 deregulation on the progression of neurodegenerative diseases and the development of drugs targeting DAPK1 for the treatment of diseases. Therefore, this review summarizes the DAPK1 phosphorylation signaling pathways in various neurodegenerative diseases.

Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, NF-κB and extracellular signal-regulated protein kinase activation

2002 ◽  
Vol 63 (8) ◽  
pp. 1507-1516 ◽  
Author(s):  
Pia Bartholomä ◽  
Nina Erlandsson ◽  
Katrin Kaufmann ◽  
Oliver G. Rössler ◽  
Bernd Baumann ◽  
...  
Keyword(s):  
Cell Death ◽  
Protein Kinase ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Kinase Activation ◽  
Protein Kinase Activation ◽  
Extracellular Signal

Inhibition of protein kinase C protects against paraoxon-mediated neuronal cell death

2007 ◽  
Vol 28 (4) ◽  
pp. 843-849 ◽  
Author(s):  
Feng Tian ◽  
Xuan Wu ◽  
Hongan Pan ◽  
Hong Jiang ◽  
Yu-Liang Kuo ◽  
...  
Keyword(s):  
Cell Death ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Kinase C

Y-27632, a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemia

2007 ◽  
Vol 246 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Akira Hirata ◽  
Masaru Inatani ◽  
Yasuya Inomata ◽  
Naoko Yonemura ◽  
Takahiro Kawaji ◽  
...  
Keyword(s):  
Cell Death ◽  
Protein Kinase ◽  
Kinase Inhibitor ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Retinal Ischemia ◽  
Protein Kinase Inhibitor
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