scholarly journals Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

2016 ◽  
Vol 23 (6) ◽  
pp. 1086-1096 ◽  
Author(s):  
L Tian ◽  
S-C Choi ◽  
H-N Lee ◽  
Y Murakami ◽  
C-F Qi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Autoimmune Disease ◽  
Cell Expansion ◽  
Memory T Cell ◽  
T Cell Expansion ◽  
Deficient Mice

Mast cells and T-cell expansion

Blood ◽  
2008 ◽  
Vol 111 (5) ◽  
pp. 2497-2498
Author(s):  
Susumu Nakae ◽  
Keisuke Oboki ◽  
Hirohisa Saito
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Mast Cells ◽  
Cell Expansion ◽  
Memory T Cells ◽  
T Cell Expansion

IgE/antigen-FcϵRI crosslinking promotes antigen internalization and apoptosis in mouse mast cells. Dendritic cells uptake the apoptotic mast cells carrying internalized antigens, and thus can efficiently present the antigens to memory T cells.

scholarly journals Tumor-associated mesenchymal stem cells inhibit naïve T cell expansion by blocking cysteine export from dendritic cells

2016 ◽  
Vol 139 (9) ◽  
pp. 2068-2081 ◽  
Author(s):  
Tithi Ghosh ◽  
Subhasis Barik ◽  
Avishek Bhuniya ◽  
Jesmita Dhar ◽  
Shayani Dasgupta ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Cell Expansion ◽  
T Cell Expansion ◽  
Naïve T Cell ◽  
Naive T Cell

scholarly journals Role of MDA5 and interferon-I in dendritic cells for T cell expansion by anti-tumor peptide vaccines in mice

2018 ◽  
Vol 67 (7) ◽  
pp. 1091-1103 ◽  
Author(s):  
Hussein Sultan ◽  
Juan Wu ◽  
Takumi Kumai ◽  
Andres M. Salazar ◽  
Esteban Celis
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Expansion ◽  
Peptide Vaccines ◽  
T Cell Expansion

scholarly journals Antigen-Specific T Cell Recall Assay To Screen Drugs For Off-Target Effects

2020 ◽  
Author(s):  
Eden Kleiman ◽  
Gloria Sierra ◽  
Dennie Magcase ◽  
Marybeth V George ◽  
Pirouz M Daftarian
Keyword(s):  
T Cell ◽  
Cell Expansion ◽  
Parent Drug ◽  
High Dose ◽  
Memory T Cell ◽  
Cell Immunity ◽  
T Cell Expansion ◽  
Adenosine Analog ◽  
Target Effects

ABSTRACTExtracellular adenosine suppresses T cell immunity in the tumor microenvironment. We have developed an in vitro recall assay utilizing a sequential adenosine dosing regimen guide for testing drug off-target effects on memory T cell expansion/function. As a proof of principle, we show low dose adenosine analog GS-5734, a monophosphoramidate prodrug of an adenosine analog, does not alter memory T cell recall whereas toxicity observed at high dose favors antigen-specific memory T cell survival/proliferation over non-specific CD8+ T cells. Parent drug GS-445124 at high dosage interferes with antigen-specific T cell recall without cellular toxicity. Despite similar chemical structure, these drugs displayed opposing effects on memory T cell expansion. This assay platform has broad utility in screening memory T cell off-target effects.

scholarly journals Effector T Cells Boost Regulatory T Cell Expansion by IL-2, TNF, OX40, and Plasmacytoid Dendritic Cells Depending on the Immune Context

2014 ◽  
Vol 194 (3) ◽  
pp. 999-1010 ◽  
Author(s):  
Audrey Baeyens ◽  
David Saadoun ◽  
Fabienne Billiard ◽  
Angéline Rouers ◽  
Sylvie Grégoire ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Expansion ◽  
Plasmacytoid Dendritic Cells ◽  
Effector T Cells ◽  
T Cell Expansion

scholarly journals Innate Signaling Promotes Formation of Regulatory Nitric Oxide–Producing Dendritic Cells Limiting T-Cell Expansion in Experimental Autoimmune Myocarditis

Circulation ◽  
2013 ◽  
Vol 127 (23) ◽  
pp. 2285-2294 ◽  
Author(s):  
Gabriela Kania ◽  
Stefanie Siegert ◽  
Silvia Behnke ◽  
Rafael Prados-Rosales ◽  
Arturo Casadevall ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Dendritic Cells ◽  
T Cell ◽  
Cell Expansion ◽  
Autoimmune Myocarditis ◽  
Experimental Autoimmune Myocarditis ◽  
T Cell Expansion ◽  
Experimental Autoimmune

Impaired in vivo CD4+ T cell expansion and differentiation in aged mice is not solely due to T cell defects: Decreased stimulation by aged dendritic cells

2011 ◽  
Vol 132 (4) ◽  
pp. 187-194 ◽  
Author(s):  
Luciana F. Pereira ◽  
Ana Paula Duarte de Souza ◽  
Thiago J. Borges ◽  
Cristina Bonorino
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Expansion ◽  
Cd4 T Cell ◽  
Aged Mice ◽  
T Cell Expansion
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