scholarly journals Dlx genes and the maintenance of bone homeostasis and skeletal integrity

2014 ◽  
Vol 21 (9) ◽  
pp. 1345-1346 ◽  
Author(s):  
G Levi ◽  
Y Gitton
Keyword(s):  
Bone Homeostasis ◽  
Dlx Genes ◽  
Skeletal Integrity

scholarly journals Influence of Iron on Bone Homeostasis

2018 ◽  
Vol 11 (4) ◽  
pp. 107 ◽  
Author(s):  
Enikő Balogh ◽  
György Paragh ◽  
Viktória Jeney
Keyword(s):  
Iron Deficiency ◽  
Iron Overload ◽  
Osteoblast Differentiation ◽  
Current Knowledge ◽  
Bone Destruction ◽  
Bone Homeostasis ◽  
Therapeutic Approaches ◽  
Skeletal Health ◽  
Complex Process ◽  
Skeletal Integrity

Bone homeostasis is a complex process, wherein osteoclasts resorb bone and osteoblasts produce new bone tissue. For the maintenance of skeletal integrity, this sequence has to be tightly regulated and orchestrated. Iron overload as well as iron deficiency disrupt the delicate balance between bone destruction and production, via influencing osteoclast and osteoblast differentiation as well as activity. Iron overload as well as iron deficiency are accompanied by weakened bones, suggesting that balanced bone homeostasis requires optimal—not too low, not too high—iron levels. The goal of this review is to summarize our current knowledge about how imbalanced iron influence skeletal health. Better understanding of this complex process may help the development of novel therapeutic approaches to deal with the pathologic effects of altered iron levels on bone.

scholarly journals METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export

2020 ◽  
Vol 21 (5) ◽  
pp. 1660 ◽  
Author(s):  
Di Li ◽  
Luhui Cai ◽  
Runsha Meng ◽  
Zhihui Feng ◽  
Qiong Xu
Keyword(s):  
Nuclear Export ◽  
Osteoclast Differentiation ◽  
Rna Stability ◽  
Cell Lineage ◽  
Specific Gene ◽  
Bone Homeostasis ◽  
Protein Levels ◽  
Lineage Differentiation ◽  
And Function ◽  
Skeletal Integrity

Osteoclast differentiation and function are crucial for maintaining bone homeostasis and preserving skeletal integrity. N6-methyladenosine (m6A) is an abundant mRNA modification that has recently been shown to be important in regulating cell lineage differentiation. Nevertheless, the effect of m6A on osteoclast differentiation remains unknown. In the present study, we observed that the m6A level and methyltransferase METTL3 expression increased during osteoclast differentiation. Mettl3 knockdown resulted in an increased size but a decreased bone-resorbing ability of osteoclasts. The expression of osteoclast-specific genes (Nfatc1, c-Fos, Ctsk, Acp5 and Dcstamp) was inhibited by Mettl3 depletion, while the expression of the cellular fusion-specific gene Atp6v0d2 was upregulated. Mechanistically, Mettl3 knockdown elevated the mRNA stability of Atp6v0d2 and the same result was obtained when the m6A-binding protein YTHDF2 was silenced. Moreover, the phosphorylation levels of key molecules in the MAPK, NF-κB and PI3K-AKT signaling pathways were reduced upon Mettl3 deficiency. Depletion of Mettl3 maintained the retention of Traf6 mRNA in the nucleus and reduced the protein levels of TRAF6. Taken together, our data suggest that METTL3 regulates osteoclast differentiation and function through different mechanisms involving Atp6v0d2 mRNA degradation mediated by YTHDF2 and Traf6 mRNA nuclear export. These findings elucidate the molecular basis of RNA epigenetic regulation in osteoclast development.

Bone homeostasis in children with Subclinical hypothyroidism: effects of two-years treatment with levothyoxine

2019 ◽  
Author(s):  
Valeria Gaeta ◽  
Lorenzo Bufalo ◽  
Paola Lorello ◽  
Raffaella Di Mase ◽  
Donatella Capalbo ◽  
...  
Keyword(s):  
Subclinical Hypothyroidism ◽  
Bone Homeostasis

Effect of sleeve gastrectomy on calcium and bone homeostasis

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Ahmed ahmed ◽  
fatma ahmed ◽  
mohamed kamar ◽  
ayman nsr allah
Keyword(s):  
Sleeve Gastrectomy ◽  
Bone Homeostasis

Lactoferrin in Bone Tissue Regeneration

2020 ◽  
Vol 27 (6) ◽  
pp. 838-853 ◽  
Author(s):  
Madalina Icriverzi ◽  
Valentina Dinca ◽  
Magdalena Moisei ◽  
Robert W. Evans ◽  
Mihaela Trif ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Cells ◽  
Bone Diseases ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Bone Tissue Regeneration ◽  
Bone Homeostasis ◽  
Active Compounds

: Among the multiple properties exhibited by lactoferrin (Lf), its involvement in bone regeneration processes is of great interest at the present time. A series of in vitro and in vivo studies have revealed the ability of Lf to promote survival, proliferation and differentiation of osteoblast cells and to inhibit bone resorption mediated by osteoclasts. Although the mechanism underlying the action of Lf in bone cells is still not fully elucidated, it has been shown that its mode of action leading to the survival of osteoblasts is complemented by its mitogenic effect. Activation of several signalling pathways and gene expression, in an LRPdependent or independent manner, has been identified. Unlike the effects on osteoblasts, the action on osteoclasts is different, with Lf leading to a total arrest of osteoclastogenesis. : Due to the positive effect of Lf on osteoblasts, the potential use of Lf alone or in combination with different biologically active compounds in bone tissue regeneration and the treatment of bone diseases is of great interest. Since the bioavailability of Lf in vivo is poor, a nanotechnology- based strategy to improve the biological properties of Lf was developed. The investigated formulations include incorporation of Lf into collagen membranes, gelatin hydrogel, liposomes, loading onto nanofibers, porous microspheres, or coating onto silica/titan based implants. Lf has also been coupled with other biologically active compounds such as biomimetic hydroxyapatite, in order to improve the efficacy of biomaterials used in the regulation of bone homeostasis. : This review aims to provide an up-to-date review of research on the involvement of Lf in bone growth and healing and on its use as a potential therapeutic factor in bone tissue regeneration.

Calcium and Vitamin D Supplementation. Myths and Realities with Regard to Cardiovascular Risk

2019 ◽  
Vol 17 (6) ◽  
pp. 610-617 ◽  
Author(s):  
Giovanna Muscogiuri ◽  
Luigi Barrea ◽  
Barbara Altieri ◽  
Carolina Di Somma ◽  
Harjit pal Bhattoa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Side Effects ◽  
Secondary Hyperparathyroidism ◽  
Calcium Supplementation ◽  
Physiological Role ◽  
Bone Diseases ◽  
Current Evidence ◽  
Bone Homeostasis ◽  
Mineral Density ◽  
Muscle Health

Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Findings from observational studies have shown controversial results regarding the association between bone mineral density and vitamin D/calcium status, thus sparking a debate regarding optimum concentrations of 25-hydroxyvitamin D and calcium for the best possible skeletal health. Although most of the intervention studies reported a positive effect of supplementation with calcium and vitamin D on bone in patients with osteoporosis, this therapeutic approach has been a matter of debate regarding potential side effects on the cardiovascular (CV) system. Thus, the aim of this review is to consider the current evidence on the physiological role of vitamin D and calcium on bone and muscle health. Moreover, we provide an overview on observational and interventional studies that investigate the effect of vitamin D and calcium supplementation on bone health, also taking into account the possible CV side-effects. We also provide molecular insights on the effect of calcium plus vitamin D on the CV system.

scholarly journals The role of gut microbiota in bone homeostasis

Bone ◽  
2020 ◽  
Vol 135 ◽  
pp. 115317 ◽  
Author(s):  
Jyotirmaya Behera ◽  
Jessica Ison ◽  
Suresh C. Tyagi ◽  
Neetu Tyagi
Keyword(s):  
Gut Microbiota ◽  
Bone Homeostasis
Sign in / Sign up

Export Citation Format

Share Document