scholarly journals E2F1-regulated miR-30b suppresses Cyclophilin D and protects heart from ischemia/reperfusion injury and necrotic cell death

2014 ◽  
Vol 22 (5) ◽  
pp. 743-754 ◽  
Author(s):  
K Wang ◽  
T An ◽  
L-Y Zhou ◽  
C-Y Liu ◽  
X-J Zhang ◽  
...  
Keyword(s):  
Cell Death ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Necrotic Cell Death ◽  
Cyclophilin D ◽  
Necrotic Cell

scholarly journals Participation of Caspase-3-Like Protease in Necrotic Cell Death of Myocardium During Ischemia -Reperfusion Injury in Rat Hearts

2003 ◽  
Vol 67 (3) ◽  
pp. 248-252 ◽  
Author(s):  
Yoshihisa Naka ◽  
Yoshiki Sawa ◽  
Motonobu Nishimura ◽  
Nobuaki Hirata ◽  
Hideki Ueda ◽  
...  
Keyword(s):  
Cell Death ◽  
Reperfusion Injury ◽  
Caspase 3 ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Rat Hearts

scholarly journals Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice

2014 ◽  
Vol 20 (11) ◽  
pp. 1372-1382 ◽  
Author(s):  
Min Yang ◽  
Daniel J. Antoine ◽  
James L. Weemhoff ◽  
Rosalind E. Jenkins ◽  
Anwar Farhood ◽  
...  
Keyword(s):  
Cell Death ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

scholarly journals miR-380-5p facilitates NRF2 and attenuates cerebral ischemia/reperfusion injury-induced neuronal cell death by directly targeting BACH1

2021 ◽  
Vol 12 (1) ◽  
pp. 210-217
Author(s):  
Yibiao Wang ◽  
Min Xu
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Luciferase Assay ◽  
Neuroprotective Effects ◽  
Cerebral Ischemia Reperfusion

Abstract Background This study aimed to explore the role of miR-380-5p in cerebral ischemia/reperfusion (CIR) injury-induced neuronal cell death and the potential signaling pathway involved. Methodology Human neuroblastoma cell line SH-SY5Y cells were used in this study. Oxygen and glucose deprivation/reperfusion (OGD/R) model was used to mimic ischemia/reperfusion injury. CCK-8 assay and flow cytometry were used to examine cell survival. Quantitative real time PCR (RT-qPCR) assay and Western blotting were used to measure the change of RNA and protein expression, respectively. TargetScan and Luciferase assay was used to confirm the target of miR-380-5p. Malondialdehyde (MDA) superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) were measured using commercial kits. Results miR-380-5p was downregulated in SH-SY5Y cells after OGD/R. Cell viability was increased by miR-380-5p, while cell apoptosis was reduced by miR-380-5p mimics. MDA was reduced by miR-380-5p mimics, while SOD and GSHPx were increased by miR-380-5p. Results of TargetScan and luciferase assay have showed that BACH1 is the direct target of miR-380-5p. Expression of NRF2 was upregulated after OGD/R, but was not affected by miR-380-5p. mRNA expression of HO-1 and NQO1 and ARE activity were increased by miR-380-5p. Overexpression of BACH1 reversed the antioxidant and neuroprotective effects of miR-380-5p. Conclusion miR-380-5p inhibited cell death induced by CIR injury through target BACH1 which also facilitated the activation of NRF2, indicating the antioxidant and neuroprotective effects of miR-380-5p.

scholarly journals Selective β 2 -Adrenoreceptor Stimulation Attenuates Myocardial Cell Death and Preserves Cardiac Function After Ischemia–Reperfusion Injury

2012 ◽  
Vol 32 (8) ◽  
pp. 1865-1874 ◽  
Author(s):  
Shashi Bhushan ◽  
Kazuhisa Kondo ◽  
Benjamin L. Predmore ◽  
Maxim Zlatopolsky ◽  
Adrienne L. King ◽  
...  
Keyword(s):  
Cell Death ◽  
Cardiac Function ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Myocardial Cell
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