scholarly journals Delayed innocent bystander cell death following hypoxia in Caenorhabditis elegans

2013 ◽  
Vol 21 (4) ◽  
pp. 557-567 ◽  
Author(s):  
C-L Sun ◽  
E Kim ◽  
C M Crowder
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Bystander Cell ◽  
Innocent Bystander ◽  
Bystander Cell Death

scholarly journals The importance of serum serotonin levels in the measurement of radiation-induced bystander cell death in HaCaT cells

2012 ◽  
Vol 88 (10) ◽  
pp. 770-772 ◽  
Author(s):  
Fiona M. Lyng ◽  
Maxime Desplanques ◽  
Kishore Kumar Jella ◽  
Amaya Garcia ◽  
Brendan McClean
Keyword(s):  
Cell Death ◽  
Hacat Cells ◽  
Bystander Cell ◽  
Radiation Induced ◽  
Bystander Cell Death ◽  
Serum Serotonin

scholarly journals Late-emerging strains of HIV induce T-cell homeostasis failure by promoting bystander cell death and immune exhaustion in naïve CD4 and all CD8 T-cells

2014 ◽  
Vol 83 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Catherine N. Kibirige ◽  
Frederick A. Menendez ◽  
Hao Zhang ◽  
Tricia L. Nilles ◽  
Susan Langan ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Death ◽  
T Cell ◽  
Cd8 T Cells ◽  
Bystander Cell ◽  
T Cell Homeostasis ◽  
Cell Homeostasis ◽  
Immune Exhaustion ◽  
Bystander Cell Death

scholarly journals Gap Junctions Mediate Bystander Cell Death in Developing Retina

2003 ◽  
Vol 23 (16) ◽  
pp. 6413-6422 ◽  
Author(s):  
Karen Cusato ◽  
Alejandra Bosco ◽  
Renato Rozental ◽  
Cinthya A. Guimarães ◽  
Benjamin E. Reese ◽  
...  
Keyword(s):  
Cell Death ◽  
Gap Junctions ◽  
Bystander Cell ◽  
Bystander Cell Death

scholarly journals The Role of Caspase-12 in Retinal Bystander Cell Death and Innate Immune Responses against MCMV Retinitis

2021 ◽  
Vol 22 (15) ◽  
pp. 8135
Author(s):  
Xinyan Zhang ◽  
Jinxian Xu ◽  
Brendan Marshall ◽  
Zheng Dong ◽  
Sylvia B. Smith ◽  
...  
Keyword(s):  
Cell Death ◽  
Caspase 3 ◽  
P53 Protein ◽  
Plaque Assay ◽  
Tunel Staining ◽  
Mrna Levels ◽  
Bystander Cell ◽  
Caspase 12 ◽  
Infected Cells ◽  
Bystander Cell Death

(1) Background: caspase-12 is activated during cytomegalovirus retinitis, although its role is presently unclear. (2) Methods: caspase-12−/− (KO) or caspase-12+/+ (WT) mice were immunosup eyes were analyzed by plaque assay, TUNEL assay, immunohistochemical staining, western blotting, and real-time PCR. (3) Results: increased retinitis and a more extensive virus spread were detected in the retina of infected eyes of KO mice compared to WT mice at day 14 p.i. Compared to MCMV injected WT eyes, mRNA levels of interferons α, β and γ were significantly reduced in the neural retina of MCMV-infected KO eyes at day 14 p.i. Although similar numbers of MCMV infected cells, similar virus titers and similar numbers of TUNEL-staining cells were detected in injected eyes of both KO and WT mice at days 7 and 10 p.i., significantly lower amounts of cleaved caspase-3 and p53 protein were detected in infected eyes of KO mice at both time points. (4) Conclusions: caspase-12 contributes to caspase-3-dependent and independent retinal bystander cell death during MCMV retinitis and may also play an important role in innate immunity against virus infection of the retina.

Bystander Cell Death and Stress Response is Inhibited by the Radical Scavenger α1-Microglobulin in Irradiated Cell Cultures

2010 ◽  
Vol 174 (5) ◽  
pp. 590-600 ◽  
Author(s):  
Magnus G. Olsson ◽  
E. J. Charlotta Nilsson ◽  
Sigurbjörg Rutardóttir ◽  
Jan Paczesny ◽  
Jan Pallon ◽  
...  
Keyword(s):  
Cell Death ◽  
Stress Response ◽  
Cell Cultures ◽  
Radical Scavenger ◽  
Bystander Cell ◽  
Bystander Cell Death

scholarly journals La Crosse Virus Infection of Human Keratinocytes Leads to Interferon-Dependent Apoptosis of Bystander Non-Infected Cells In Vitro

Viruses ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 253 ◽  
Author(s):  
Maria Cruz ◽  
Griffith Parks
Keyword(s):  
Cell Death ◽  
Neutralizing Antibodies ◽  
Human Keratinocytes ◽  
Target Cells ◽  
Hacat Cells ◽  
La Crosse Virus ◽  
Bystander Cell ◽  
Infected Cells ◽  
Bystander Cell Death

Resident cells in the skin serve as the first innate line of defense against insect-borne pathogens, but the role of these cell types in promoting or limiting arbovirus replication is not completely understood. Here, we have examined the outcome of infection of cultured human keratinocyte cells with La Crosse virus (LACV), using a spontaneously transformed cell line, HaCaT. In single cycle infections, keratinocyte HaCaT cells supported rapid and high level LACV replication, resulting in high virus yields and extensive caspase-dependent cell death. By contrast, multi-cycle LACV replication in HaCaT cells was restricted by an antiviral response elicited by the production of both IFN-β and IFN-λ. During low multiplicity LACV infections, HaCaT cell death was seen in non-infected bystander cells. Media from LACV-infected cells induced caspase-dependent killing of naïve non-infected HaCaT cells, and this bystander cell death was relieved by IFN-β neutralizing antibodies or by an inhibitor of JAK-STAT signaling. Naïve HaCaT cells showed dose-dependent killing by treatment with exogenous IFN-β but not IFN-λ. Our data suggest a model whereby keratinocytes produce IFNs which limit virus spread through both antiviral signaling and by induction of bystander cell death of potential new target cells for infection.

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