scholarly journals Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization

2012 ◽  
Vol 19 (9) ◽  
pp. 1536-1548 ◽  
Author(s):  
T Arnandis ◽  
I Ferrer-Vicens ◽  
E R García-Trevijano ◽  
V J Miralles ◽  
C García ◽  
...  
Keyword(s):  
Cell Death ◽  
Mammary Gland ◽  
Epithelial Cell ◽  
Mammary Gland Involution ◽  
Epithelial Cell Death

Differential functions of calpain 1 during epithelial cell death and adipocyte differentiation in mammary gland involution

2014 ◽  
Vol 459 (2) ◽  
pp. 355-368 ◽  
Author(s):  
Teresa Arnandis ◽  
Ivan Ferrer-Vicens ◽  
Luis Torres ◽  
Concha García ◽  
Elena R. Garcia-Trevijano ◽  
...  
Keyword(s):  
Cell Death ◽  
Mammary Gland ◽  
Epithelial Cell ◽  
Programmed Cell Death ◽  
Adipocyte Differentiation ◽  
Histone H3 ◽  
Tissue Remodelling ◽  
Mammary Gland Involution ◽  
Epithelial Cell Death

The results of the present study unveil novel and important nuclear functions of calpains in tissue remodelling. Although inducing nuclear permeability during programmed cell death, histone H3 is identified as a new target of calpain-1 upon adipocyte differentiation.

scholarly journals Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution

Development ◽  
2011 ◽  
Vol 139 (2) ◽  
pp. 269-275 ◽  
Author(s):  
J. O'Brien ◽  
H. Martinson ◽  
C. Durand-Rougely ◽  
P. Schedin
Keyword(s):  
Cell Death ◽  
Mammary Gland ◽  
Epithelial Cell ◽  
Mammary Gland Involution ◽  
Epithelial Cell Death

scholarly journals Polyhexamethylene Guanidine Phosphate Induces Apoptosis through Endoplasmic Reticulum Stress in Lung Epithelial Cells

2021 ◽  
Vol 22 (3) ◽  
pp. 1215
Author(s):  
Mi Ho Jeong ◽  
Mi Seon Jeon ◽  
Ga Eun Kim ◽  
Ha Ryong Kim
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Epithelial Cell ◽  
Er Stress ◽  
Lung Fibrosis ◽  
A549 Cells ◽  
Polyhexamethylene Guanidine ◽  
Lung Epithelial ◽  
Epithelial Cell Death ◽  
Guanidine Phosphate

Airway epithelial cell death contributes to the pathogenesis of lung fibrosis. Polyhexamethylene guanidine phosphate (PHMG-p), commonly used as a disinfectant, has been shown to be strongly associated with lung fibrosis in epidemiological and toxicological studies. However, the molecular mechanism underlying PHMG-p-induced epithelial cell death is currently unclear. We synthesized a PHMG-p–fluorescein isothiocyanate (FITC) conjugate and assessed its uptake into lung epithelial A549 cells. To examine intracellular localization, the cells were treated with PHMG-p–FITC; then, the cytoplasmic organelles were counterstained and observed with confocal microscopy. Additionally, the organelle-specific cell death pathway was investigated in cells treated with PHMG-p. PHMG-p–FITC co-localized with the endoplasmic reticulum (ER), and PHMG-p induced ER stress in A549 cells and mice. The ER stress inhibitor tauroursodeoxycholic acid (TUDCA) was used as a pre-treatment to verify the role of ER stress in PHMG-p-induced cytotoxicity. The cells treated with PHMG-p showed apoptosis, which was inhibited by TUDCA. Our results indicate that PHMG-p is rapidly located in the ER and causes ER-stress-mediated apoptosis, which is an initial step in PHMG-p-induced lung fibrosis.

scholarly journals Sirtuin 1 Promotes Hyperoxia-Induced Lung Epithelial Cell Death Independent of NF-E2–Related Factor 2 Activation

2016 ◽  
Vol 54 (5) ◽  
pp. 697-706 ◽  
Author(s):  
Haranatha R. Potteti ◽  
Subbiah Rajasekaran ◽  
Senthilkumar B. Rajamohan ◽  
Chandramohan R. Tamatam ◽  
Narsa M. Reddy ◽  
...  
Keyword(s):  
Cell Death ◽  
Epithelial Cell ◽  
Lung Epithelial Cell ◽  
Sirtuin 1 ◽  
Related Factor ◽  
Lung Epithelial ◽  
Epithelial Cell Death

Mechanisms of Bile Acid-Induced Intestinal Epithelial Cell Death

2014 ◽  
Vol 219 (3) ◽  
pp. S14-S15
Author(s):  
Anne S. Roberts ◽  
Stephanie C. Papillon ◽  
Avafia Y. Roberts ◽  
Mark R. Frey ◽  
Henri R. Ford ◽  
...  
Keyword(s):  
Cell Death ◽  
Bile Acid ◽  
Epithelial Cell ◽  
Intestinal Epithelial Cell ◽  
Intestinal Epithelial ◽  
Epithelial Cell Death

scholarly journals Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation

2020 ◽  
Vol 34 (7) ◽  
pp. 9450-9465
Author(s):  
Ayano Iwaki ◽  
Kenta Moriwaki ◽  
Tomoaki Sobajima ◽  
Manabu Taniguchi ◽  
Shin‐ichiro Yoshimura ◽  
...  
Keyword(s):  
Cell Death ◽  
Small Intestine ◽  
Epithelial Cell ◽  
Lipid Accumulation ◽  
Epithelial Cell Death
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