scholarly journals Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors

2012 ◽  
Vol 20 (4) ◽  
pp. 567-575 ◽  
Author(s):  
T Montero-Melendez ◽  
J Dalli ◽  
M Perretti
Keyword(s):  
Gene Expression ◽  
Histone Deacetylase ◽  
Mechanism Of Action ◽  
Histone Deacetylase Inhibitors ◽  
Gene Expression Signature ◽  
Expression Signature

scholarly journals The gene expression signature of anagrelide provides an insight into its mechanism of action and uncovers new regulators of megakaryopoiesis

2015 ◽  
Vol 13 (6) ◽  
pp. 1103-1112 ◽  
Author(s):  
M. Ahluwalia ◽  
L. Butcher ◽  
H. Donovan ◽  
C. Killick‐Cole ◽  
P. M. Jones ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mechanism Of Action ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Insight Into

scholarly journals Further investigation of the potential anti-neoplastic, anti-inflammatory and immunomodulatory actions of phenoxybenzamine using the Broad Institute CLUE platform

2019 ◽  
Author(s):  
Mario A. Inchiosa
Keyword(s):  
Gene Expression ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Glycogen Synthase ◽  
Human Tumor ◽  
Gene Expression Signature ◽  
Broad Institute ◽  
Adrenergic Antagonist ◽  
Gene Expression Signatures ◽  
Anti Inflammatory

AbstractPrevious clinical studies with the FDA-approved alpha-adrenergic antagonist, phenoxybenzamine, showed apparent efficacy to reverse the symptoms and disabilities of the neuropathic condition, Complex Regional Pain Syndrome; also, the anatomic spread and intensity of this syndrome has a proliferative character and it was proposed that phenoxybenzamine may have an anti-inflammatory, immunomodulatory mode of action. A previous study gave evidence that phenoxybenzamine had anti-proliferative activity in suppression of growth in several human tumor cell cultures. The same report demonstrated that the drug possessed significant histone deacetylase inhibitory activity. Utilizing the Harvard/Massachusetts Institute of Technology Broad Institute genomic database, CLUE, the present study suggests that the gene expression signature of phenoxybenzamine in malignant cell lines is consistent with anti-inflammatory/immunomodulatory activity and suppression of tumor expansion by several possible mechanisms of action. Of particular note, phenoxybenzamine demonstrated signatures that were highly similar to those with glucocorticoid agonist activity. Also, gene expression signatures of phenoxbenzamine were consistent with several agents in each case that were known to suppress tumor proliferation, notably, protein kinase C inhibitors, Heat Shock Protein inhibitors, epidermal growth factor receptor inhibitors, and glycogen synthase kinase inhibitors. Searches in CLUE also confirmed the earlier observations of strong similarities between gene expression signatures of phenoxybenzamine and several histone deacetylase inhibitors.

scholarly journals A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents

Allergy ◽  
2020 ◽  
Vol 75 (12) ◽  
pp. 3248-3260 ◽  
Author(s):  
Nathanaël Lemonnier ◽  
Erik Melén ◽  
Yale Jiang ◽  
Stéphane Joly ◽  
Camille Ménard ◽  
...  
Keyword(s):  
Gene Expression ◽  
Children And Adolescents ◽  
Whole Blood ◽  
Gene Expression Signature ◽  
Blood Gene Expression ◽  
Expression Signature
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