scholarly journals Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation

2010 ◽  
Vol 17 (9) ◽  
pp. 1448-1462 ◽  
Author(s):  
L Xiao ◽  
L-L Gong ◽  
D Yuan ◽  
M Deng ◽  
X-M Zeng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Cell Survival ◽  
Protein Phosphatase ◽  
Signal Transduction Pathway ◽  
Protein Phosphatase 1 ◽  
Transduction Pathway ◽  
Control Gene ◽  
Control Gene Expression

Signal Transduction Pathway Leading to Hsp27 and Hsp70 Gene Expression during Myocardial Adaptation to Stressa

1998 ◽  
Vol 851 (1 STRESS OF LIF) ◽  
pp. 129-138 ◽  
Author(s):  
DIPAK K. DAS ◽  
NILANJANA MAULIK ◽  
RICHARD M. ENGELMAN ◽  
JOHN A. ROUSOU ◽  
DAVID DEATON ◽  
...  
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Signal Transduction Pathway ◽  
Hsp70 Gene ◽  
Transduction Pathway ◽  
Myocardial Adaptation

scholarly journals MicroRNAs in Platelets: Should I Stay or Should I Go?

Platelets ◽  
2020 ◽  
Author(s):  
Sonia Águila ◽  
Ernesto Cuenca-Zamora ◽  
Constantino Martínez ◽  
Raúl Teruel-Montoya
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Extracellular Vesicles ◽  
Intercellular Communication ◽  
Noncoding Rnas ◽  
Signal Transduction Pathway ◽  
Response To Therapy ◽  
Transduction Pathway ◽  
Small Noncoding Rnas ◽  
And Function

In this chapter, we discuss different topics always using the microRNA as the guiding thread of the review. MicroRNAs, member of small noncoding RNAs family, are an important element involved in gene expression. We cover different issues such as their importance in the differentiation and maturation of megakaryocytes (megakaryopoiesis), as well as the role in platelets formation (thrombopoiesis) focusing on the described relationship between miRNA and critical myeloid lineage transcription factors such as RUNX1, chemokines receptors as CRCX4, or central hormones in platelet homeostasis like TPO, as well as its receptor (MPL) and the TPO signal transduction pathway, that is JAK/STAT. In addition to platelet biogenesis, we review the microRNA participation in platelets physiology and function. This review also introduces the use of miRNAs as biomarkers of platelet function since the detection of pathogenic situations or response to therapy using these noncoding RNAs is getting increasing interest in disease management. Finally, this chapter describes the participation of platelets in cellular interplay, since extracellular vesicles have been demonstrated to have the ability to deliver microRNAs to others cells, modulating their function through intercellular communication, redefining the extracellular vesicles from the so-called “platelet dust” to become mediators of intercellular communication.

Fenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway

2007 ◽  
Vol 84 (5) ◽  
pp. 886-893 ◽  
Author(s):  
Jaetaek Kim ◽  
Ji-Hyun Ahn ◽  
Jeong-Hun Kim ◽  
Young-Suk Yu ◽  
Ho-Shik Kim ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Endothelial Cell ◽  
Cell Survival ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Endothelial Cell Survival ◽  
Retinal Endothelial Cell
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