scholarly journals Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway

2009 ◽  
Vol 16 (6) ◽  
pp. 899-909 ◽  
Author(s):  
G Liot ◽  
B Bossy ◽  
S Lubitz ◽  
Y Kushnareva ◽  
N Sejbuk ◽  
...  
Keyword(s):  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Mitochondrial Fragmentation ◽  
Complex Ii ◽  
Dependent Pathway

Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-xL/Bcl-w antagonist ABT-737

2010 ◽  
Vol 58 (8) ◽  
pp. 1258-1267 ◽  
Author(s):  
Kenneth W. Young ◽  
Lucia G.P. Piñón ◽  
Dalbir Dhiraj ◽  
Davina Twiddy ◽  
Marion MacFarlane ◽  
...  
Keyword(s):  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Mitochondrial Fragmentation

scholarly journals c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death

2017 ◽  
Vol 8 (10) ◽  
pp. e3117-e3117 ◽  
Author(s):  
Lujun Zhou ◽  
Qiang Zhang ◽  
Peng Zhang ◽  
Lei Sun ◽  
Can Peng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Mitochondrial Fragmentation

scholarly journals Zika Virus-Induced Neuronal Apoptosis via Increased Mitochondrial Fragmentation

2020 ◽  
Vol 11 ◽  
Author(s):  
Shu Yang ◽  
Kirill Gorshkov ◽  
Emily M. Lee ◽  
Miao Xu ◽  
Yu-Shan Cheng ◽  
...  
Keyword(s):  
Cell Death ◽  
Zika Virus ◽  
Neuronal Apoptosis ◽  
Mitochondrial Dynamics ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Mitochondrial Fragmentation ◽  
Zikv Infection ◽  
Mitofusin 2 ◽  
Infected Cells

The 2015 to 2016 outbreak of Zika virus (ZIKV) infections in the Americas coincided with a dramatic increase in neurodevelopmental abnormalities, including fetal microcephaly, in newborns born to infected women. In this study, we observed mitochondrial fragmentation and disrupted mitochondrial membrane potential after 24 h of ZIKV infection in human neural stem cells and the SNB-19 glioblastoma cell line. The severity of these changes correlated with the amount of ZIKV proteins expressed in infected cells. ZIKV infection also decreased the levels of mitofusin 2, which modulates mitochondria fusion. Mitochondrial division inhibitor 1 (Mdivi-1), a small molecule inhibiting mitochondria fission, ameliorated mitochondria disruptions and reduced cell death in ZIKV-infected cells. Collectively, this study suggests that abnormal mitochondrial fragmentation contributes to ZIKV-induced neuronal cell death; rebalancing mitochondrial dynamics of fission-fusion could be a therapeutic strategy for drug development to treat ZIKV-mediated neuronal apoptosis.

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