PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum

A Saavedra; J M García-Martínez; X Xifró; A Giralt; J F Torres-Peraza; J M Canals; M Díaz-Hernández; J J Lucas; J Alberch; E Pérez-Navarro

doi:10.1038/cdd.2009.127

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum

Cell Death and Differentiation ◽

10.1038/cdd.2009.127 ◽

2009 ◽

Vol 17 (2) ◽

pp. 324-335 ◽

Cited By ~ 32

Author(s):

A Saavedra ◽

J M García-Martínez ◽

X Xifró ◽

A Giralt ◽

J F Torres-Peraza ◽

...

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Protein Phosphatase ◽

Protein Phosphatase 1 ◽

Leucine Rich Repeat ◽

Ph Domain ◽

Repeat Protein ◽

Survival Pathway ◽

Leucine Rich Repeat Protein

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Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation

Journal of Biological Chemistry ◽

10.1074/jbc.m114.612937 ◽

2015 ◽

Vol 290 (26) ◽

pp. 16272-16280 ◽

Cited By ~ 23

Author(s):

Elizabeth W. Bradley ◽

Lomeli R. Carpio ◽

Alexandra C. Newton ◽

Jennifer J. Westendorf

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Protein Phosphatase ◽

Protein Phosphatase 1 ◽

Fibroblast Growth ◽

Leucine Rich Repeat ◽

Ph Domain ◽

Chondrocyte Proliferation ◽

Repeat Protein ◽

Leucine Rich Repeat Protein

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PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1)

Atlas of Genetics and Cytogenetics in Oncology and Haematology ◽

10.4267/2042/44755 ◽

2011 ◽

Author(s):

AK O'Neill ◽

AC Newton

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 1 ◽

Leucine Rich Repeat ◽

Ph Domain ◽

Repeat Protein ◽

Leucine Rich Repeat Protein

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WD Repeat Protein WDR48 in Complex with Deubiquitinase USP12 Suppresses Akt-dependent Cell Survival Signaling by Stabilizing PH Domain Leucine-rich Repeat Protein Phosphatase 1 (PHLPP1)

Journal of Biological Chemistry ◽

10.1074/jbc.m113.503383 ◽

2013 ◽

Vol 288 (48) ◽

pp. 34545-34554 ◽

Cited By ~ 39

Author(s):

Narmadha Reddy Gangula ◽

Subbareddy Maddika

Keyword(s):

Cell Survival ◽

Protein Phosphatase ◽

Protein Phosphatase 1 ◽

Leucine Rich Repeat ◽

Ph Domain ◽

Repeat Protein ◽

Dependent Cell ◽

Survival Signaling ◽

Wd Repeat ◽

Leucine Rich Repeat Protein

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PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP)

Encyclopedia of Signaling Molecules ◽

10.1007/978-1-4614-6438-9_101823-1 ◽

2016 ◽

pp. 1-7

Author(s):

Agnieszka T. Grzechnik ◽

Alexandra C. Newton

Keyword(s):

Protein Phosphatase ◽

Leucine Rich Repeat ◽

Ph Domain ◽

Repeat Protein ◽

Leucine Rich Repeat Protein

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S. pombe gene sds22+ essential for a midmitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-1

Cell ◽

10.1016/0092-8674(91)90216-l ◽

1991 ◽

Vol 64 (1) ◽

pp. 149-157 ◽

Cited By ~ 117

Author(s):

Hiroyuki Ohkura ◽

Mitsuhiro Yanagida

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 1 ◽

Leucine Rich Repeat ◽

Repeat Protein ◽

Leucine Rich Repeat Protein

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Discovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening

Journal of Medicinal Chemistry ◽

10.1021/jm100331d ◽

2010 ◽

Vol 53 (19) ◽

pp. 6899-6911 ◽

Cited By ~ 49

Author(s):

Emma Sierecki ◽

William Sinko ◽

J. Andrew McCammon ◽

Alexandra C. Newton

Keyword(s):

Virtual Screening ◽

Small Molecule ◽

Protein Phosphatase ◽

Small Molecule Inhibitors ◽

Leucine Rich Repeat ◽

Ph Domain ◽

Repeat Protein ◽

Leucine Rich Repeat Protein

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MicroRNA-331-3p promotes proliferation and metastasis of hepatocellular carcinoma by targeting PH domain and leucine-rich repeat protein phosphatase

Hepatology ◽

10.1002/hep.27221 ◽

2014 ◽

Vol 60 (4) ◽

pp. 1251-1263 ◽

Cited By ~ 101

Author(s):

Rui-Min Chang ◽

Hao Yang ◽

Feng Fang ◽

Jiang-Feng Xu ◽

Lian-Yue Yang

Keyword(s):

Hepatocellular Carcinoma ◽

Protein Phosphatase ◽

Leucine Rich Repeat ◽

Ph Domain ◽

Repeat Protein ◽

Proliferation And Metastasis ◽

Leucine Rich Repeat Protein

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PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2)

Atlas of Genetics and Cytogenetics in Oncology and Haematology ◽

10.4267/2042/44756 ◽

2011 ◽

Author(s):

AK O'Neill ◽

AC Newton

Keyword(s):

Protein Phosphatase ◽

Leucine Rich Repeat ◽

Ph Domain ◽

Repeat Protein ◽

Protein Phosphatase 2 ◽

Leucine Rich Repeat Protein

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Expression of PH Domain Leucine-rich Repeat Protein Phosphatase, Forkhead Homeobox Type O 3a and RAD51, and their Relationships with Clinicopathologic Features and Prognosis in Ovarian Serous Adenocarcinoma

Chinese Medical Journal ◽

10.4103/0366-6999.198932 ◽

2017 ◽

Vol 130 (3) ◽

pp. 280-287 ◽

Cited By ~ 1

Author(s):

Jun Zhang ◽

Jun-Chao Wang ◽

Yue-Hong Li ◽

Rui-Xue Wang ◽

Xiao-Mei Fan

Keyword(s):

Protein Phosphatase ◽

Clinicopathologic Features ◽

Leucine Rich Repeat ◽

Ph Domain ◽

Serous Adenocarcinoma ◽

Repeat Protein ◽

Ovarian Serous Adenocarcinoma ◽

Leucine Rich Repeat Protein

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Regulation Of Neutrophil Adhesion And Migration By PH Domain And Leucine Rich Repeat Protein Phosphatase

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1380 ◽

2012 ◽

Author(s):

Xiangdong Zhu ◽

Jonathan Learoyd ◽

Lee Tang ◽

Linda Ning ◽

Zuo-Hui Shao ◽

...

Keyword(s):

Protein Phosphatase ◽

Neutrophil Adhesion ◽

Leucine Rich Repeat ◽

Ph Domain ◽

Repeat Protein ◽

And Migration ◽

Leucine Rich Repeat Protein

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