scholarly journals The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis

2009 ◽  
Vol 16 (11) ◽  
pp. 1480-1492 ◽  
Author(s):  
W Malorni ◽  
M G Farrace ◽  
P Matarrese ◽  
A Tinari ◽  
L Ciarlo ◽  
...  
Keyword(s):  
Adenine Nucleotide ◽  
Adenine Nucleotide Translocator ◽  
Adenine Nucleotide Translocator 1

Lack of apoptosis in patients with progressive external ophthalmoplegia and mutated adenine nucleotide translocator-1 gene

2002 ◽  
Vol 26 (2) ◽  
pp. 265-269 ◽  
Author(s):  
Gigliola Fagiolari ◽  
Monica Sciacco ◽  
Luca Chiveri ◽  
Costanza Lamperti ◽  
Giacomo Pietro Comi ◽  
...  
Keyword(s):  
Adenine Nucleotide ◽  
Progressive External Ophthalmoplegia ◽  
Adenine Nucleotide Translocator ◽  
Adenine Nucleotide Translocator 1

scholarly journals Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition

2020 ◽  
Author(s):  
Wanfeng Xu ◽  
Yuan Che ◽  
Quan Zhang ◽  
Hai Huang ◽  
Chujie Ding ◽  
...  
Keyword(s):  
Bile Acids ◽  
Caspase 3 ◽  
Mitochondrial Permeability Transition ◽  
Adenine Nucleotide ◽  
Permeability Transition ◽  
Calcium Overload ◽  
List Type ◽  
Adenine Nucleotide Translocator ◽  
Mitochondrial Permeability ◽  
Adenine Nucleotide Translocator 1

SUMMARYCaspase-4 directly senses and is activated by cytosolic LPS in conditions of pathogen infection. It is unclear whether and how caspase-4 detects host derived factors for triggering pyroptosis. Here we show that mitochondrial permeability transition (MPT) promotes the assembly of a protein complex comprised of Apaf-1 and caspase-4 (caspase-11 in mice), defined herein as pyroptosome, for the execution of facilitated pyroptosis. MPT induced by bile acids and calcium overload, and specifically by an adenine nucleotide translocator 1 (ANT1) activator, triggered pyroptosome assembly. Different from the direct cleavage of GSDMD by LPS-activated caspase-4, caspase-4 activated in the Apaf-1 pyroptosome proceeds to cleave caspase-3 and thereby gasdermin E (GSDME) to induce pyroptosis. Caspase-11 initiated and GSDME executed pyroptosis underlies cholesteric liver failure. These findings identify Apaf-1 pyroptosome as a pivotal machinery for cells sensing MPT signals and may shed lights on understanding how cells execute pyroptosis under sterile conditions.HighlightsBile acids trigger caspase-4/11 and GSDME dependent pyroptosisCaspase-4/11 is a general sensor of mitochondrial permeability transition (MPT)MPT drives Apaf-1/capase-4 pryoptosome assemblyCaspase-11 and GSDME mediated pyroptosis underlies cholesteric liver damageeTOC BlurbPersistent mitochondrial permeability transition elicited by bile acids, calcium overload and specifically ANT1 activators drives assembly of Apaf-1-capase-4/11 pyroptosome triggering GSDME dependent pryroptosis.

scholarly journals Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup

2013 ◽  
Vol 110 (9) ◽  
pp. 3453-3458 ◽  
Author(s):  
Kevin A. Strauss ◽  
Lauren DuBiner ◽  
Mariella Simon ◽  
Michael Zaragoza ◽  
Partho P. Sengupta ◽  
...  
Keyword(s):  
Adenine Nucleotide ◽  
Adenine Nucleotide Translocator ◽  
Adenine Nucleotide Translocator 1 ◽  
Mtdna Haplogroup
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