scholarly journals Assessment of bone turnover and bone quality in type 2 diabetic bone disease: current concepts and future directions

Bone Research ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Mishaela R Rubin ◽  
Janina M Patsch
Keyword(s):  
Bone Turnover ◽  
Bone Quality ◽  
Bone Disease ◽  
Future Directions ◽  
Type 2 Diabetic

scholarly journals Vitamin D is associated with blood lead exposure through bone turnover in type 2 diabetes patients

2021 ◽  
Vol 10 (4) ◽  
pp. 378-386
Author(s):  
Haojie Zhang ◽  
Yuke Cui ◽  
Ruihua Dong ◽  
Wen Zhang ◽  
Shihan Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Bone Turnover ◽  
Lead Exposure ◽  
Bone Turnover Markers ◽  
Blood Lead ◽  
Mediation Analyses ◽  
Turnover Markers ◽  
Type 2 Diabetic

Background Bone is thought to be the reservoir of the human lead burden, and vitamin D is associated with bone turnover. We aimed to explore whether exposure to lower 25-hydroxy vitamin D (25(OH)D) levels was associated with higher blood lead levels (BLLs) by increasing the bone turnover rate in individuals with type 2 diabetes. Methods A total of 4103 type 2 diabetic men and postmenopausal women in Shanghai, China, were enrolled in 2018. Their 25(OH)D, β-C-terminal telopeptide (β-CTX), N-MID osteocalcin and procollagen type 1 N-peptide (P1NP) levels were detected. Their BLLs were determined by atomic absorption spectrometry. Mediation analyses were performed to identify the possible role that bone turnover played in the underlying mechanisms. Results In both the men and postmenopausal women, all three bone turnover markers were inversely associated with 25(OH)D and positively associated with the BLL (all P < 0.01) after adjusting for age, current smoking habits, metabolic parameters, duration of diabetes, vitamin D intake, and use of anti-osteoporosis medication. In the mediation analyses, none of the direct associations between 25(OH)D and BLL was significant for the three bone turnover markers, but all three bone turnover markers were found to be significant mediators of the indirect associations between 25(OH)D and BLL. Conclusion The association between vitamin D and BLL was fully mediated by bone turnover markers in type 2 diabetic patients (mediation effect). This finding suggested that vitamin D may protect against blood lead exposure from the bone reservoir by decreasing bone turnover in individuals with type 2 diabetes.

scholarly journals Study of bone turnover markers, procollagen type 1 N-terminal propeptide and osteocalcin in healthy and type 2 diabetes mellitus postmenopausal women

2020 ◽  
Vol 8 (8) ◽  
pp. 2839
Author(s):  
G. G. Kaushik ◽  
Rajesh Chahar ◽  
Subhash Chandra
Keyword(s):  
Diabetes Mellitus ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Bone Turnover Markers ◽  
Diabetic Group ◽  
Procollagen Type ◽  
Turnover Markers ◽  
Type 2 Diabetic

Background: Individuals with diabetes mellitus are at increased risk of metabolic bone disease due to decrease in bone strength and quality. Several bone turnover markers like serum procollagen type I N propeptide (P1NP) and serum osteocalcin are powerful tools for studying osteoporosis and fracture risk across population to provide diagnostic and prognostic information of bone health. The aim of this study was to recognize possible correlation of levels of serum P1NP and osteocalcin in type-2 diabetic (T2DM) postmenopausal women as compared to healthy postmenopausal women.Methods: The study included 100 proven cases of type-2 diabetic postmenopausal women with age matched healthy postmenopausal women as controls. P1NP, osteocalcin, and other relevant parameters were measured. Differences between diabetics and controls were analyzed.Results: The body mass index was higher in diabetic group as compared to controls. The HbA1c% was (6.94±1.43) in diabetic group and (5.57±1.21) in non-diabetics. Low serum level of 25 (OH) D was observed both in diabetic and non-diabetic groups but significantly lower in T2DM. Procollagen type 1 N propeptide was lower in diabetic group (37.59±17.20 ng/mL) as compared to non-diabetic (52.14±24.82 ng/mL). Osteocalcin was lower (15.64±8.06 ng/ml) as compared to non-diabetic group (21.85±9.12 ng/ml). Lower osteocalcin and P1NP levels found in this study suggests slower bone metabolism with reduced bone formation in postmenopausal diabetics.Conclusions: Serum procollagen type 1 N propeptide and osteocalcin in postmenopausal diabetic women were lower as compared to non-diabetic group.

Selected markers of bone turnover in type 2 diabetic patients

2012 ◽  
Vol 25 (4) ◽  
pp. 367-372
Author(s):  
Arleta Malecha-Jędraszek ◽  
◽  
Agata Burska ◽  
Helena Donica ◽  
Beata Matuszek ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Markers Of Bone Turnover ◽  
Type 2 Diabetic

Effect of GLP-1 Treatment on Bone Turnover in Normal, Type 2 Diabetic, and Insulin-Resistant States

2009 ◽  
Vol 84 (6) ◽  
pp. 453-461 ◽  
Author(s):  
Bernardo Nuche-Berenguer ◽  
Paola Moreno ◽  
Pedro Esbrit ◽  
Sonia Dapía ◽  
José R. Caeiro ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Normal Type ◽  
Insulin Resistant ◽  
Type 2 Diabetic

Bone Markers (BMKs) and its Relation with Peripheral Neuropathy (PNP) in Type 2 Diabetic Patient (T2DM) in Basrah

2021 ◽  
Vol 19 (12) ◽  
pp. 50-54
Author(s):  
Shaimaa Sadiq Ahmed ◽  
Mustafa Abd Almajeed ◽  
Ali Abdulla AL Idani
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Bone Turnover ◽  
Diabetic Patient ◽  
Bone Metabolism ◽  
Diabetic Peripheral Neuropathy ◽  
Bone Markers ◽  
Markers Of Bone Turnover ◽  
Type 2 Diabetic

The aim of this study was to evaluate differences in bone metabolism by calculating markers of bone turnover (C-terminal telopeptide and osteocalcin) with type 2 diabetes and patients in diabetic peripheral neuropathy patients compared with those without diabetic peripheral neuropathy.

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