scholarly journals High prevalence of small- and large-fiber neuropathy in a prospective cohort of patients with moderate to severe chronic GvHD

2016 ◽  
Vol 51 (11) ◽  
pp. 1513-1517 ◽  
Author(s):  
E Bilic ◽  
V Delimar ◽  
L Desnica ◽  
D Pulanic ◽  
E Bilic ◽  
...  
Keyword(s):  
Prospective Cohort ◽  
Chronic Gvhd ◽  
High Prevalence ◽  
Large Fiber ◽  
Large Fiber Neuropathy

The High Prevalence of Epstein-Barr Virus in Adults with Bronchiectasis: A Prospective Cohort Study

2019 ◽  
Author(s):  
Chun-Lan Chen ◽  
Yan Huang ◽  
Miguel Angel Martinez-Garcia ◽  
Jing-Jing Yuan ◽  
Hui-Min Li ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
High Prevalence ◽  
Epstein Barr

A reappraisal of the presence of small or large fiber neuropathy in patients with erythromelalgia

2021 ◽  
Author(s):  
Pauline Reach ◽  
Isabelle Lazareth ◽  
François Coudore ◽  
Audrey Stansal ◽  
Raphaël Attal ◽  
...  
Keyword(s):  
Large Fiber ◽  
Large Fiber Neuropathy

MO45 Peripheral large fiber neuropathy in patients with erectile dysfunction

2008 ◽  
Vol 119 ◽  
pp. S42
Author(s):  
Consuelo Valles-Antuña ◽  
Jesús M Fernández-Gómez ◽  
Safwan Escaf-Barmadah ◽  
Jose Luis Martín-Benito ◽  
Fernando Fernández-González
Keyword(s):  
Erectile Dysfunction ◽  
Large Fiber ◽  
Large Fiber Neuropathy

scholarly journals High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Roger I. Calderon ◽  
Maria B. Arriaga ◽  
Kattya Lopez ◽  
Nadia N. Barreda ◽  
Oswaldo M. Sanabria ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Laboratory Tests ◽  
Diagnostic Performance ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Poor Agreement ◽  
Household Contacts ◽  
High Prevalence

Abstract Background The accuracy of different laboratory tests for diagnosis of diabetes mellitus (DM) and prediabetes (preDM) in populations exposed to tuberculosis (TB) remains poorly understood. Here, we examined the prevalence of DM and preDM in TB affected people in Lima, Peru. Methods A prospective cohort study of patients affected TB and their household contacts (HHC), was conducted between February and November 2017 in Lima, Peru. Fasting plasma glucose (FPG), HbA1c and oral glucose tolerance test (OGTT) were used to detect DM and preDM in a prospective cohort of TB patients (n = 136) and household contacts (n = 138). Diagnostic performance of the laboratory tests was analyzed. Potential effects of sociodemographic and clinical factors on detection of dysglycemia were analyzed. Results In TB patients, prevalence of DM and preDM was 13.97 and 30.88% respectively. Lower prevalence of both DM (6.52%) and preDM (28.99%) were observed in contacts. FPG, HbA1c and OGTT had poor agreement in detection of preDM in either TB cases or contacts. TB-DM patients had substantially lower hemoglobin levels, which resulted in low accuracy of HbA1c-based diagnosis. Classic sociodemographic and clinical characteristics were not different between TB patients with or without dysglycemia. Conclusion High prevalence of DM and preDM was found in both TB patients and contacts in Lima. Anemia was strongly associated with TB-DM, which directly affected the diagnostic performance of HbA1c in such population.

Small and large fiber neuropathy in those with type 1 and type 2 diabetes: a 5-year follow-up study

2016 ◽  
Vol 21 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Sissel Løseth ◽  
Erik V. Stålberg ◽  
Sigurd Lindal ◽  
Edel Olsen ◽  
Rolf Jorde ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Follow Up Study ◽  
Large Fiber ◽  
Large Fiber Neuropathy

scholarly journals Prevalence and Characteristics of Persistent Symptoms After Non-Severe COVID-19: A Prospective Cohort Study

2021 ◽  
Author(s):  
Lucas Armange ◽  
François Bénézit ◽  
Léa Picard ◽  
Charlotte Pronier ◽  
Stéphanie Guillot ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Chest Ct ◽  
Lung Function Tests ◽  
Persistent Symptoms ◽  
High Prevalence ◽  
Disabled Patients ◽  
Chest Ct Scan

Abstract We performed a prospective cohort study of 311 outpatients with non-severe COVID-19 (187 women, median age 39 years). Of the 214 (68.8%) who completed the 6-week follow-up questionnaire, 115 (53.7%) had recovered. Others mostly reported dyspnea (n=86, 40.2%), weight loss (n=83, 38.8%), sleep disorders (n=68, 31.8%), and anxiety (n=56, 26.2%). Of those who developed ageusia and anosmia, these symptoms were still present at week 6 in, respectively, 11/111 (9.9%), and 19/114 (16.7%). Chest CT scan and lung function tests found no explanation in the most disabled patients (n=23). This study confirms the high prevalence of persistent symptoms after non-severe COVID-19.

scholarly journals Neuropathic pain in adult Myotonic Dystrophy type 1.  Presence of small and large fibre neuropathy?

2020 ◽  
Author(s):  
Gro Solbakken ◽  
Sissel Løseth ◽  
Terje Nærland ◽  
Jan Frich ◽  
Espen Dietrichs ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Myotonic Dystrophy Type 1 ◽  
Myotonic Dystrophy Type ◽  
Fiber Density ◽  
Epidermal Nerve Fiber Density ◽  
Large Fiber ◽  
Nerve Fiber Density ◽  
Large Fiber Neuropathy ◽  
Epidermal Nerve Fiber

Abstract Background: Myotonic Dystrophy type 1 (DM1) is an inherited neuromuscular disorder affecting multiple organs. There is an increasing awareness of chronic pain in DM1. In this cross-sectional study, we investigated symptoms of neuropathic pain and small and large fiber neuropathy in the adult form of DM1. We also studied if neuropathy was related to the number of CTG repeats, disease duration and other clinical DM1 symptoms, and investigated if skin biopsy tests for small fiber neuropathy differed in the DM1 group compared to reference values from healthy controls.Methods: 20 genetically verified DM1 adult patients were included in the study. Pain descriptions, neurologic examination and objective investigations of the peripheral nerve system by quantitative sensory testing, skin biopsies and neurography were conducted. Statistical analyses of group differences and frequencies were performed.Results: Six patients (30%) out of 20 patients with DM1 described neuropathic pain, and three of these had objective findings on both small and large fiber neuropathy, as well as clinically sensory findings. Together, large and/or small fibre neuropathy is present in 50% of the patients with DM1. The intra epidermal nerve fiber density was significantly lower (p= <0.001, Cohen`s d = 1.2) in the 20 patients with DM1 (mean 8.16, SD: 2.28) compared to a reference group (N = 106, mean 12.43, SD: 4.59). Patients with large fiber neuropathy had significantly lower muscle strength (p = 0.01, Cohen`s d = 1.6, mean difference 0.4, CI: 0.7 - 0.1) than patients without large fiber neuropathy.Conclusion: Symptoms of neuropathic pain was more frequent in patients with DM1 compared to the general population. Intra epidermal nerve fiber density was significantly lower in the DM1 group than in a sample of healthy controls. Neuropathy may be a mechanism of pain in DM1.

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