scholarly journals Confounding factors affecting the National Institutes of Health (NIH) chronic Graft-Versus-Host Disease Organ-Specific Score and global severity

2016 ◽  
Vol 51 (10) ◽  
pp. 1350-1353 ◽  
Author(s):  
S Z Aki ◽  
Y Inamoto ◽  
P A Carpenter ◽  
B E Storer ◽  
B M Sandmaier ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
National Institutes Of Health ◽  
Confounding Factors ◽  
Host Disease ◽  
Factors Affecting ◽  
Graft Versus Host ◽  
Organ Specific ◽  
Specific Score

scholarly journals Confounding Factors Affecting the National Institutes of Health (NIH) Chronic GVHD Organ-Specific Score and Global Severity

2014 ◽  
Vol 20 (2) ◽  
pp. S265-S266 ◽  
Author(s):  
Sahika Zeynep Aki ◽  
Yoshihiro Inamoto ◽  
Barry E. Storer ◽  
Paul A. Carpenter ◽  
Stephanie J. Lee ◽  
...  
Keyword(s):  
Chronic Gvhd ◽  
National Institutes Of Health ◽  
Confounding Factors ◽  
Factors Affecting ◽  
Organ Specific ◽  
Specific Score

scholarly journals Benefits and challenges with diagnosing chronic and late acute GVHD in children using the NIH consensus criteria

Blood ◽  
2019 ◽  
Vol 134 (3) ◽  
pp. 304-316 ◽  
Author(s):  
Geoffrey D. E. Cuvelier ◽  
Eneida R. Nemecek ◽  
Justin T. Wahlstrom ◽  
Carrie L. Kitko ◽  
Victor A. Lewis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Graft Versus Host Disease ◽  
Acute Gvhd ◽  
Bronchiolitis Obliterans Syndrome ◽  
National Institutes Of Health ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
Nih Consensus Criteria ◽  
Adjudication Committee

Abstract Chronic graft-versus-host disease (cGVHD) and late acute graft-versus-host disease (L-aGVHD) are understudied complications of allogeneic hematopoietic stem cell transplantation in children. The National Institutes of Health Consensus Criteria (NIH-CC) were designed to improve the diagnostic accuracy of cGVHD and to better classify graft-versus-host disease (GVHD) syndromes but have not been validated in patients <18 years of age. The objectives of this prospective multi-institution study were to determine: (1) whether the NIH-CC could be used to diagnose pediatric cGVHD and whether the criteria operationalize well in a multi-institution study; (2) the frequency of cGVHD and L-aGVHD in children using the NIH-CC; and (3) the clinical features and risk factors for cGVHD and L-aGVHD using the NIH-CC. Twenty-seven transplant centers enrolled 302 patients <18 years of age before conditioning and prospectively followed them for 1 year posttransplant for development of cGVHD. Centers justified their cGVHD diagnosis according to the NIH-CC using central review and a study adjudication committee. A total of 28.2% of reported cGVHD cases was reclassified, usually as L-aGVHD, following study committee review. Similar incidence of cGVHD and L-aGVHD was found (21% and 24.7%, respectively). The most common organs involved with diagnostic or distinctive manifestations of cGVHD in children include the mouth, skin, eyes, and lungs. Importantly, the 2014 NIH-CC for bronchiolitis obliterans syndrome perform poorly in children. Past acute GVHD and peripheral blood grafts are major risk factors for cGVHD and L-aGVHD, with recipients ≥12 years of age being at risk for cGVHD. Applying the NIH-CC in pediatrics is feasible and reliable; however, further refinement of the criteria specifically for children is needed.

scholarly journals Refined National Institutes of Health response algorithm for chronic graft-versus-host disease in joints and fascia

2020 ◽  
Vol 4 (1) ◽  
pp. 40-46
Author(s):  
Yoshihiro Inamoto ◽  
Stephanie J. Lee ◽  
Lynn E. Onstad ◽  
Mary E. D. Flowers ◽  
Betty K. Hamilton ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Therapeutic Response ◽  
Chronic Gvhd ◽  
National Institutes Of Health ◽  
Host Disease ◽  
Graft Versus Host ◽  
Health Response ◽  
Key Points ◽  
Total P

Key Points The NIH joint/fascia score and total P-ROM score should be used for assessing therapeutic response in joint/fascia chronic GVHD. A change from 0 to 1 on the NIH joint/fascia score should not be considered as worsening.

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