scholarly journals Impact of sex incompatibility on the outcome of single-unit cord blood transplantation for adult patients with hematological malignancies

2014 ◽  
Vol 49 (5) ◽  
pp. 634-639 ◽  
Author(s):  
T Konuma ◽  
S Kato ◽  
J Ooi ◽  
M Oiwa-Monna ◽  
Y Ebihara ◽  
...  
Keyword(s):  
Cord Blood ◽  
Single Unit ◽  
Hematological Malignancies ◽  
Cord Blood Transplantation ◽  
Adult Patients ◽  
Blood Transplantation

scholarly journals Cytokine Profiles of Pre-Engraftment Syndrome after Single-Unit Cord Blood Transplantation for Adult Patients

2017 ◽  
Vol 23 (11) ◽  
pp. 1932-1938 ◽  
Author(s):  
Takaaki Konuma ◽  
Chisato Kohara ◽  
Eri Watanabe ◽  
Motoko Mizukami ◽  
Etsuko Nagai ◽  
...  
Keyword(s):  
Cord Blood ◽  
Single Unit ◽  
Cord Blood Transplantation ◽  
Adult Patients ◽  
Cytokine Profiles ◽  
Blood Transplantation ◽  
Engraftment Syndrome

Candida colonization is associated with severe acute GVHD in adult patients undergoing single‐unit cord blood transplantation

2019 ◽  
Vol 104 (1) ◽  
pp. 74-76 ◽  
Author(s):  
Takaaki Konuma ◽  
Mai Mizusawa ◽  
Masato Suzuki ◽  
Yuta Kaito ◽  
Masamichi Isobe ◽  
...  
Keyword(s):  
Cord Blood ◽  
Single Unit ◽  
Acute Gvhd ◽  
Cord Blood Transplantation ◽  
Adult Patients ◽  
Candida Colonization ◽  
Blood Transplantation

Intensified Myeloablative Conditioning Regimen without Antithymocytic (ATG) Results in Superior Patient Outcome Compared to Myeloablative Conditioning Regimen for Single-Unit Umbilical Cord Blood Transplantation in Hematological Malignancies

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 5837-5837
Author(s):  
Zimin Sun ◽  
Huilan Liu ◽  
Yue Wu ◽  
Changcheng Zheng ◽  
Baolin Tang ◽  
...  
Keyword(s):  
Cord Blood ◽  
Cumulative Incidence ◽  
Single Unit ◽  
Hematological Malignancies ◽  
Cord Blood Transplantation ◽  
Conditioning Regimen ◽  
Myeloablative Conditioning ◽  
Blood Transplantation ◽  
Group A ◽  
Neutrophil Engraftment

Abstract The superiority and safety of strengthening conditioning regimen for single- unit unrelated cord blood transplantation (sUCBT) in hematological malignancies remain controversial. We retrospectively analyzed the clinical data of 251 hematological malignancies undergoing sUCBT from Apr 2000 to Dec 2014 at Department of hematology in Anhui Provincial Hospital. Out of the 251 patients, 216 received the intensified myeloablative conditioning regimen (IMCR), and 35 received the myeloablative conditioning regimen (MCR). We evaluated the effect of IMCR without using Antithymocyte globulin (ATG) on patient outcomes. The cumulative incidence of myeloid and platelet engraftment of the IMCR group was significantly higher than that in the MCR group (96.98% vs. 82.81%, 85.89% vs. 51.79%, P=0.000 and 0.003, respectively). Corresponding incidences of transplantation-related mortality (TRM) by 180 days in the IMCR group and the MCR group were 19.50% vs. 41.67% (P=0.003), respectively. There were no differences in the incidence of grade II to IV acute GVHD (aGVDH), grade III to IV aGVHD and 2-year cumulative incidence of relapse. Up to Dec. 2015, with a median follow-up of 30 months, the estimated 3-year overall survival and disease- free survival in the IMCR group were both significantly higher than that of the MCR group (64.8% vs. 35.5%, 61.6% vs. 35.5%, P=0.000 and 0.001, respectively). This study is the first to show the superiority of intensified myeloablative regimen to conventional myeloablative regimen.A large-scale prospective study was needed. (A) (B) Figure 1 The cumulative incidence of neutrophil and platelet engraftment of the IMCR group and MCR group. (A)The cumulative incidence of neutrophil engraftment of the IMCR group was predominantly higher than that in the MCR group(96.98% vs. 82.81%, P=0.000). (B)The cumulative incidence of platelet engraftment of the IMCR group was also higher than that in the MCR group(85.89% vs. 51.79%, P=0.003). Figure 1. The cumulative incidence of neutrophil and platelet engraftment of the IMCR group and MCR group. (A)The cumulative incidence of neutrophil engraftment of the IMCR group was predominantly higher than that in the MCR group(96.98% vs. 82.81%, P=0.000). (B)The cumulative incidence of platelet engraftment of the IMCR group was also higher than that in the MCR group(85.89% vs. 51.79%, P=0.003). Figure 2 Comparison of the incidence of 3-year OS between the IMCR group and the MCR group.The incidence of 3-year OS of the IMCR group is predominantly higher than that of the MCR group(62.4% vs. 35.5%,P=0.001). Figure 2. Comparison of the incidence of 3-year OS between the IMCR group and the MCR group.The incidence of 3-year OS of the IMCR group is predominantly higher than that of the MCR group(62.4% vs. 35.5%,P=0.001). Figure 3 Figure 3. Disclosures No relevant conflicts of interest to declare.

Impact of hematogones on the long-term outcomes of single-unit cord blood transplantation for adult patients

2016 ◽  
Vol 58 (1) ◽  
pp. 118-126 ◽  
Author(s):  
Hiroto Ishii ◽  
Takaaki Konuma ◽  
Seiko Kato ◽  
Maki Oiwa-Monna ◽  
Arinobu Tojo ◽  
...  
Keyword(s):  
Cord Blood ◽  
Single Unit ◽  
Cord Blood Transplantation ◽  
Adult Patients ◽  
Long Term Outcomes ◽  
Blood Transplantation

scholarly journals Phase II study of intrabone single unit cord blood transplantation for hematological malignancies

2017 ◽  
Vol 108 (8) ◽  
pp. 1634-1639 ◽  
Author(s):  
Makoto Murata ◽  
Yoshinobu Maeda ◽  
Masayoshi Masuko ◽  
Yasushi Onishi ◽  
Tomoyuki Endo ◽  
...  
Keyword(s):  
Cord Blood ◽  
Phase Ii ◽  
Single Unit ◽  
Hematological Malignancies ◽  
Phase Ii Study ◽  
Cord Blood Transplantation ◽  
Blood Transplantation
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