scholarly journals Long-term outcome of HLA-haploidentical hematopoietic SCT without in vitro T-cell depletion for adult severe aplastic anemia after modified conditioning and supportive therapy

2014 ◽  
Vol 49 (4) ◽  
pp. 519-524 ◽  
Author(s):  
L Gao ◽  
Y Li ◽  
Y Zhang ◽  
X Chen ◽  
L Gao ◽  
...  
Keyword(s):  
T Cell ◽  
Aplastic Anemia ◽  
Supportive Therapy ◽  
Cell Depletion ◽  
Severe Aplastic Anemia ◽  
Term Outcome ◽  
T Cell Depletion ◽  
Long Term Outcome

Favourable Long-Term Outcome after Matched Sibling Transplantation for Fanconi-Anemia (FA) and in vivo T-Cell Depletion

2008 ◽  
Vol 220 (3) ◽  
pp. 147-152 ◽  
Author(s):  
K. Huck ◽  
H. Hanenberg ◽  
W. Nürnberger ◽  
D. Dilloo ◽  
S. Burdach ◽  
...  
Keyword(s):  
T Cell ◽  
Fanconi Anemia ◽  
Cell Depletion ◽  
Term Outcome ◽  
T Cell Depletion ◽  
Long Term Outcome ◽  
Matched Sibling

scholarly journals In vitro tests for distinguishing possible immune-mediated aplastic anemia from transfusion-induced sensitization

Blood ◽  
1980 ◽  
Vol 55 (2) ◽  
pp. 211-215 ◽  
Author(s):  
BJ Torok-Storb ◽  
C Sieff ◽  
R Storb ◽  
J Adamson ◽  
ED Thomas
Keyword(s):  
T Cells ◽  
T Cell ◽  
Aplastic Anemia ◽  
Colony Growth ◽  
Cell Depletion ◽  
In Vitro Tests ◽  
T Cell Depletion ◽  
Immune Mediated ◽  
Before And After

Abstract Forty-two patients with aplastic anemia (AA) were studied to determine whether or not transfusion-induced sensitization is responsible for the in vitro inhibition by patient lymphocytes of HLA-identical erythroid burst-forming units (BFU-E). The results indicate that lymphocytes from 12 of 34 transfused patients inhibited normal colony growth. In contrast, lymphocytes from none of the 8 untransfused patients demonstrated inhibition. These data were interpreted to mean that coculture studies would not be useful for identifying immune-mediated AA in transfused patients. Therefore, in order to identify possible immune-related AA, we assayed BFU-E from patient blood before and after T-cell depletion. In all 32 patients studied, BFU-E failed to grow from peripheral blood cells before T-cell depletion, but in 8 cases, normal- appearing BFU-E grew after T cells had been removed. Growth of patient BFU-E colonies was inhibited in 6 cases when patient T cells were added back to the culture, indicating that in these 6 patients, an “autoimmune” mechanism may have been present.

scholarly journals A novel protocol for haploidentical hematopoietic SCT without in vitro T-cell depletion in the treatment of severe acquired aplastic anemia

2012 ◽  
Vol 47 (12) ◽  
pp. 1507-1512 ◽  
Author(s):  
L P Xu ◽  
K Y Liu ◽  
D H Liu ◽  
W Han ◽  
H Chen ◽  
...  
Keyword(s):  
T Cell ◽  
Aplastic Anemia ◽  
Cell Depletion ◽  
T Cell Depletion

scholarly journals Long-term outcome of pregnancy complicating with severe aplastic anemia under supportive care

2017 ◽  
Vol 56 (5) ◽  
pp. 632-635 ◽  
Author(s):  
Kuan-Ju Chen ◽  
Yao-Lung Chang ◽  
Horng Chang ◽  
Shen-Yuan Su ◽  
Hsiu-Huei Peng ◽  
...  
Keyword(s):  
Supportive Care ◽  
Aplastic Anemia ◽  
Severe Aplastic Anemia ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals In vitro tests for distinguishing possible immune-mediated aplastic anemia from transfusion-induced sensitization

Blood ◽  
1980 ◽  
Vol 55 (2) ◽  
pp. 211-215
Author(s):  
BJ Torok-Storb ◽  
C Sieff ◽  
R Storb ◽  
J Adamson ◽  
ED Thomas
Keyword(s):  
T Cells ◽  
T Cell ◽  
Aplastic Anemia ◽  
Colony Growth ◽  
Cell Depletion ◽  
In Vitro Tests ◽  
T Cell Depletion ◽  
Immune Mediated ◽  
Before And After

Forty-two patients with aplastic anemia (AA) were studied to determine whether or not transfusion-induced sensitization is responsible for the in vitro inhibition by patient lymphocytes of HLA-identical erythroid burst-forming units (BFU-E). The results indicate that lymphocytes from 12 of 34 transfused patients inhibited normal colony growth. In contrast, lymphocytes from none of the 8 untransfused patients demonstrated inhibition. These data were interpreted to mean that coculture studies would not be useful for identifying immune-mediated AA in transfused patients. Therefore, in order to identify possible immune-related AA, we assayed BFU-E from patient blood before and after T-cell depletion. In all 32 patients studied, BFU-E failed to grow from peripheral blood cells before T-cell depletion, but in 8 cases, normal- appearing BFU-E grew after T cells had been removed. Growth of patient BFU-E colonies was inhibited in 6 cases when patient T cells were added back to the culture, indicating that in these 6 patients, an “autoimmune” mechanism may have been present.

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