scholarly journals New-onset microalbuminuria following allogeneic myeloablative SCT is a sign of near-term decrease in renal function

2013 ◽  
Vol 48 (7) ◽  
pp. 972-976 ◽  
Author(s):  
T Morito ◽  
M Ando ◽  
T Kobayashi ◽  
K Kakihana ◽  
K Ohashi ◽  
...  
Keyword(s):  
Renal Function ◽  
Near Term ◽  
New Onset

scholarly journals Nitrofurantoin-Associated Acute Granulomatous Interstitial Nephritis

2021 ◽  
Vol 9 ◽  
pp. 232470962110016
Author(s):  
B. K. Anupama ◽  
Parth Sampat ◽  
Harvir S. Gambhir
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Case Report ◽  
Interstitial Nephritis ◽  
Visual Hallucination ◽  
Kidney Injury ◽  
Corticosteroid Administration ◽  
Granulomatous Interstitial Nephritis ◽  
Rare Association ◽  
New Onset

We report the case of a 71-year-old female who was incidentally found to have nonoliguric acute kidney injury on a routine workup for new-onset visual hallucination. Further history revealed inadvertent usage of nitrofurantoin for 3 months for an anticipated urological procedure. Renal biopsy demonstrated acute granulomatous interstitial nephritis. The renal function significantly improved following discontinuation of nitrofurantoin and corticosteroid administration. We highlight a rare association of nitrofurantoin with acute granulomatous interstitial nephritis through this case report.

Predicting renal functional outcomes after surgery for renal cortical tumors: A multifactorial retrospective analysis

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e16005-e16005
Author(s):  
R. Korets ◽  
L. Barlow ◽  
M. Laudano ◽  
M. Benson ◽  
J. McKiernan
Keyword(s):  
Renal Function ◽  
Retrospective Analysis ◽  
Surgical Approach ◽  
Surgical Procedure ◽  
Functional Outcomes ◽  
Renal Tumors ◽  
Renal Surgery ◽  
Percent Change ◽  
Ckd Stage ◽  
New Onset

e16005 Background: Nephrectomy (Nx) is the standard of care for localized renal tumors. The risk of developing chronic renal insufficiency (CRI) increases after renal surgery. This study examines the functional outcomes for radical and partial Nx stratified by pre- and perioperative variables using estimated GFR. Methods: Using the Columbia Urologic Oncology Database, a retrospective analysis of patients treated with partial or radical Nx for renal cancer from 1988 to 2008 was conducted. Postoperative chronic renal function was measured using GFR as estimated by the MDRD study equation. Three primary outcomes were measured: 1) presence of new onset postoperative CRI (defined as GFR lower than 60 mL/min per 1.73 m2), 2) percent change in postoperative GFR from preoperative value, and 3) change in CRI stage postoperatively. Regression models were used to determine the effect of surgical procedure (radical vs partial Nx), approach, and multiple preoperative characteristics on functional outcomes. Results: 174 patients met the criteria for analysis after radical Nx and 102 after partial Nx for a total of 276 patients. 209 patients had preoperative GFR > 60, 67 had preoperative GFR < 60, and 6 had preoperative GFR < 30. After a minimum of 3 months postoperatively, 108/209 (52%) and 2/209 (1%) patients developed new-onset GFR <60 and <30, respectively. On multivariate analysis controlling for age, sex, race, diabetes and hypertension, preoperative CKD stage (p<0.001) and procedure (p<0.001) were both independent predictors of GFR progression to <60; similarly, preoperative CKD stage (p<0.001) and procedure (p<0.01) were independent predictors of percent change in postoperative GFR. Patient with worsened preoperative CRI stage were less likely to have further progression of CRI postoperatively (p<0.001) independent of the surgical procedure. Surgical approach was not an independent predictor of any renal functional outcomes measured. Conclusions: Patients undergoing renal surgery have a high rate of new-onset postoperative renal failure. After controlling for preoperative risk factors, patients undergoing radical Nx are at higher risk for decline in renal function. Surgical approach, however, was not a significant predictor for the development of CRI. No significant financial relationships to disclose.

scholarly journals The Effect of the Supine Position on Renal Function in the Near-Term Pregnant Woman12

1955 ◽  
Vol 34 (6) ◽  
pp. 777-781 ◽  
Author(s):  
Jack A. Pritchard ◽  
Allan C. Barnes ◽  
Richard H. Bright
Keyword(s):  
Renal Function ◽  
Supine Position ◽  
Near Term

scholarly journals Rhabdomyolysis: a rare adverse effect of levetiracetam

2019 ◽  
Vol 12 (8) ◽  
pp. e230851 ◽  
Author(s):  
Liza Thomas ◽  
Madiha Muhammed Farooq Mirza ◽  
Niaz Ahmed Shaikh ◽  
Nahla Ahmed
Keyword(s):  
Risk Factors ◽  
Adverse Effect ◽  
Creatine Kinase ◽  
Renal Function ◽  
Normal Renal Function ◽  
Downward Trend ◽  
Healthy Male ◽  
Clonic Seizures ◽  
New Onset

A 62-year-old previously healthy male was admitted with new onset generalised tonic-clonic seizures. Treatment was initiated with the antiepileptic levetiracetam and he had no further episodes of seizures. Creatine kinase (CPK) level was 1812 IU/L 12-hour postadmission. Despite good hydration, his CPK levels continued to rise dramatically and reached a level of 19 000 IU/L on day 5. This rise was unexplained as he did not have any further seizures and had a normal renal function. In the absence of other risk factors, the rare possibility of levetiracetam being responsible for the disproportionately high CPK was considered. Within 12 hours of withdrawal of levetiracetam, there was a downward trend in the CPK levels, with a 10-fold decrease in CPK levels over the next 4 days. This is only the ninth case reported in literature regarding this rare and potentially serious adverse effect of levetiracetam.

Abstract 2659: Increased Cystatin C Serum Levels Improve Risk Stratification in Patients with Acute Coronary Syndrome and Normal Glomerular Filtration Rate

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Jose Garcia-Acuna ◽  
Eva Garcia-Babarro ◽  
Mario Gutierrez ◽  
Jose Ramon Gonzalez-Juanatey
Keyword(s):  
Heart Failure ◽  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Renal Function ◽  
Filtration Rate ◽  
Serum Levels ◽  
Coronary Syndrome ◽  
Artery Disease ◽  
New Onset

Use of Cystatin C serum levels (CC) is a more sensible marker of renal function than serum Creatinine levels (Cr) and Glomerular Filtration Rate (GFR). Previous studies have shown that increased serum CC levels with normal GFR in a population with cardiovascular risks factors but without any cardiovascular disease is associated with increased cardiovascular events but this was not analyzed in ischemic heart disease patients. We prospectively studied 203 patients hospitalized with Acute Coronary Syndrome (ACS). Serum CC levels were determined in the first 24 hours of hospitalization in all cases and two groups were identified (>and< 0.95 mg/L). GFR was calculated by MDRD formulation using the first serum Cr determination in all patients and were established two groups (> and < 60 ml/min/1.73m2). Coronariography was performed in all patients. During 13 months follow-up period we analyzed Mayor Adverse Coronary Events (MACE) and Mortality. Patients with serum CC levels >0.95 were older, with higher hypertension prevalence, prior stroke, high frequency of renal disease and greater severity of coronary artery disease (42% patients with three-vessel coronary artery disease, p=0.05). During the follow-up these patients showed a significantly higher risk of heart failure new-onset (62% p=0.001) and mortality (14 %, p=0.001). Patients with GFR >60 and serum CC levels <0.95 presented significantly higher values of MACE (61%; p=0.001) and mortality (8%; p=0.001) in opposition to 18% and 3% respectively in the group of patients with GFR 3 60 and serum CC levels 30.95. Nevertheless significant prognostic differences between GFR >60 and serum CC levels <0.95 group and GFR >60 and serum CC levels >0.95 group were observed. In the multivariate analysis was observed than serum CC levels was an independent predictor to develop of new-onset heart failure (RR: 3.9 CI 95% 1.5–9.9; p=0.002), and mortality (RR: 2. CI 95% 1.2–3.6, p=0.001) during the follow-up. Serum CC levels are a powerful both mortality and heart failure predictor in patients with high risk ACS. High serum CC levels in patients with ACS and normal renal function identify a higher risk group. Serum CC determination may be include in the risk evaluation of patients with ACS.

T-sejt-mediált rejectio gyakorisága vesetranszplantáció után, újonnan kialakult diabetes mellitusban

2015 ◽  
Vol 156 (19) ◽  
pp. 785-789 ◽  
Author(s):  
Bernadett Borda ◽  
Edit Szederkényi ◽  
Csaba Lengyel ◽  
Tamás Várkonyi ◽  
Zoltán Hódi ◽  
...  
Keyword(s):  
Renal Function ◽  
Kidney Transplantation ◽  
T Cell ◽  
Cyclosporine A ◽  
Histological Evaluation ◽  
Pathological Effect ◽  
Tissue Samples ◽  
Onset Diabetes ◽  
Significant Difference ◽  
New Onset

Introduction: New-onset diabetes is one of the most common complications after kidney transplantation. Aim: The aims of the authors were to examine the frequency of new-onset diabetes mellitus in kidney transplanted patients receiving cyclosporine A (n = 95) and tacrolimus (n = 102) and to analyze the occurrence of T-cell mediated rejection in these two groups of patients. Method: Age, laboratory results, renal function and histological findings were evaluated one year after kidney transplantation. Histological evaluation was performed according to the 2007 modification of the Banff 1997 classification. Results: New-onset diabetes developed in 12% of patients receiving cyclosporine A-based immunosuppression and in 24% of patients taking tacrolimus (p = 0.002). Uric acid level (p = 0.002) and the age of the recipient (p = 0.003) were significantly different in the new-onset diabetic and non-diabetic groups, while renal function showed no significant difference. Evaluation of tissue samples revealed a significant difference in T-cell mediated rejection between the new-onset diabetic and non-diabetic groups (13 vs. 8 patients; 37% vs. 6%; p = 0.001). Conclusions: The results indicate an early development of the pathological effect of new-onset diabetes after kidney transplantation on the morphology of the renal allograft. Orv. Hetil., 2015, 156(19), 785–789.

scholarly journals Comparison of Efficacy and Safety of Rosuvastatin, Atorvastatin and Pravastatin among Dyslipidemic Diabetic Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Lolwa Barakat ◽  
Amin Jayyousi ◽  
Abdulbari Bener ◽  
Bilal Zuby ◽  
Mahmoud Zirie
Keyword(s):  
Renal Function ◽  
Electronic Medical Records ◽  
Medical Records ◽  
Large Scale ◽  
Population Based ◽  
Diabetic Patients ◽  
Population Based Study ◽  
Number Of Patients ◽  
Second Year ◽  
New Onset

Objectives. To investigate the efficacy and the safety of the three most commonly prescribed statins (rosuvastatin, atorvastatin, and pravastatin) for managing dyslipidemia among diabetic patients in Qatar. Subjects and Methods. This retrospective observational population-based study included 350 consecutive diabetes patients who were diagnosed with dyslipidemia and prescribed any of the indicated statins between September 2005 and September 2009. Data was collected by review of the Pharmacy Database, the Electronic Medical Records Database (EMR viewer), and the Patient's Medical Records. Comparisons of lipid profile measurements at baseline and at first- and second-year intervals were taken. Results. Rosuvastatin (10 mg) was the most effective at reducing LDL-C (29.03%). Atorvastatin reduced LDL-C the most at a dose of 40 mg (22.8%), and pravastatin reduced LDL-C the most at a dose of 20 mg (20.3%). All three statins were safe in relation to muscular and hepatic functions. In relation to renal function, atorvastatin was the safest statin as it resulted in the least number of patients at the end of 2 years of treatment with the new onset of microalbuminuria (10.9%) followed by rosuvastatin (14.3%) and then pravastatin (26.6%). Conclusion. In the Qatari context, the most effective statin at reducing LDL-C was rosuvastatin 10 mg. Atorvastatin was the safest statin in relation to renal function. Future large-scale prospective studies are needed to confirm these results.

Sign in / Sign up

Export Citation Format

Share Document