scholarly journals Early evaluation of natural killer activity in post-transplant acute myeloid leukemia patients

2009 ◽  
Vol 45 (5) ◽  
pp. 862-871 ◽  
Author(s):  
G Pittari ◽  
G Fregni ◽  
L Roguet ◽  
A Garcia ◽  
A-L Vataire ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Natural Killer ◽  
Myeloid Leukemia ◽  
Natural Killer Activity ◽  
Killer Activity ◽  
Early Evaluation ◽  
Post Transplant ◽  
Acute Myeloid

Siglec-7 is an indicator of natural killer cell function in acute myeloid leukemia

2021 ◽  
Vol 99 ◽  
pp. 107965
Author(s):  
Liu Yang ◽  
Yuanyuan Feng ◽  
Shanshan Wang ◽  
Shanyue Jiang ◽  
Longxiang Tao ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Myeloid Leukemia ◽  
Cell Function ◽  
Killer Cell ◽  
Natural Killer Cell Function ◽  
Acute Myeloid

scholarly journals Prognostic Impacts of D816V KIT Mutation and Peri-Transplant RUNX1–RUNX1T1 MRD Monitoring on Acute Myeloid Leukemia with RUNX1–RUNX1T1

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 336
Author(s):  
Byung-Sik Cho ◽  
Gi-June Min ◽  
Sung-Soo Park ◽  
Silvia Park ◽  
Young-Woo Jeon ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Residual Disease ◽  
Prognostic Significance ◽  
Poor Survival ◽  
Hematopoietic Stem ◽  
Kit Mutation ◽  
Time Points ◽  
Post Transplant ◽  
Acute Myeloid

The prognostic significance of KIT mutations and optimal thresholds and time points of measurable residual disease (MRD) monitoring for acute myeloid leukemia (AML) with RUNX1-RUNX1T1 remain controversial in the setting of hematopoietic stem cell transplantation (HSCT). We retrospectively evaluated 166 high-risk patients who underwent allogeneic (Allo-HSCT, n = 112) or autologous HSCT (Auto-HSCT, n = 54). D816V KIT mutation, a subtype of exon 17 mutations, was significantly associated with post-transplant relapse and poor survival, while other types of mutations in exons 17 and 8 were not associated with post-transplant relapse. Pre- and post-transplant RUNX1–RUNX1T1 MRD assessments were useful for predicting post-transplant relapse and poor survival with a higher sensitivity at later time points. Survival analysis for each stratified group by D816V KIT mutation and pre-transplant RUNX1–RUNX1T1 MRD status demonstrated that Auto-HSCT was superior to Allo-HSCT in MRD-negative patients without D816V KIT mutation, while Allo-HSCT was superior to Auto-HSCT in MRD-negative patients with D816V KIT mutation. Very poor outcomes of pre-transplant MRD-positive patients with D816V KIT mutation suggested that this group should be treated in clinical trials. Risk stratification by both D816V KIT mutation and RUNX1–RUNX1T1 MRD status will provide a platform for decision-making or risk-adapted therapeutic approaches.

scholarly journals Two-Stage Priming of Allogeneic Natural Killer Cells for the Treatment of Patients with Acute Myeloid Leukemia: A Phase I Trial

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0123416 ◽  
Author(s):  
Panagiotis D. Kottaridis ◽  
Janet North ◽  
Maria Tsirogianni ◽  
Chloe Marden ◽  
Edward R. Samuel ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Natural Killer Cells ◽  
Phase I ◽  
Natural Killer ◽  
Myeloid Leukemia ◽  
Phase I Trial ◽  
Two Stage ◽  
Killer Cells ◽  
Acute Myeloid

Age-Associated Alterations on Natural Killer Cells in Acute Myeloid Leukemia Patients

2019 ◽  
pp. 2243-2266
Author(s):  
Beatriz Sánchez-Correa ◽  
Carmen Campos ◽  
Alejandra Pera ◽  
Juan M. Bergua ◽  
Esther Duran ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Myeloid Leukemia ◽  
Killer Cells ◽  
Acute Myeloid
Sign in / Sign up

Export Citation Format

Share Document