scholarly journals Safety and preliminary efficacy of plerixafor (Mozobil) in combination with chemotherapy and G-CSF: an open-label, multicenter, exploratory trial in patients with multiple myeloma and non-Hodgkin's lymphoma undergoing stem cell mobilization

2009 ◽  
Vol 45 (1) ◽  
pp. 39-47 ◽  
Author(s):  
M J Dugan ◽  
R T Maziarz ◽  
W I Bensinger ◽  
A Nademanee ◽  
J Liesveld ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Stem Cell ◽  
Hodgkin’S Lymphoma ◽  
Stem Cell Mobilization ◽  
Hodgkin's Lymphoma ◽  
Open Label ◽  
Exploratory Trial ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Cell Mobilization

Intensive Dose Ifosfamide and Etoposide with G-CSF for Stem Cell Mobilization in Patients with Non-Hodgkin's Lymphoma

1999 ◽  
Vol 35 (3-4) ◽  
pp. 317-324 ◽  
Author(s):  
M. L. Donato ◽  
R. E. Champlin ◽  
K. W. van Besien ◽  
M. Korbling ◽  
F. Cabanillas ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hodgkin’S Lymphoma ◽  
Stem Cell Mobilization ◽  
Hodgkin's Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Cell Mobilization

Effects of Pretransplantation Treatment With Rituximab on Outcomes of Autologous Stem-Cell Transplantation for Non-Hodgkin's Lymphoma

2004 ◽  
Vol 22 (22) ◽  
pp. 4561-4566 ◽  
Author(s):  
Amy L. Hoerr ◽  
Feng Gao ◽  
Josephine Hidalgo ◽  
Divya Tiwari ◽  
Kristie A. Blum ◽  
...  
Keyword(s):  
Overall Survival ◽  
Stem Cell ◽  
Hodgkin’S Lymphoma ◽  
Stem Cell Mobilization ◽  
Hodgkin's Lymphoma ◽  
Post Transplantation ◽  
Intermediate Grade ◽  
Non Hodgkin's Lymphoma ◽  
Cell Mobilization ◽  
Disease Free

Purpose To analyze the effects of preautografting treatment with rituximab (R) on stem-cell mobilization, post-transplantation complications, engraftment, disease-free survival, and overall survival in patients with non-Hodgkin's lymphoma (NHL). Patients and Methods Single-institution retrospective comparative outcome analysis in a cohort of 273 relapsed chemosensitive NHL patients of whom 127 (47%) received R pretransplantation. Results R was administered a median of 3 months before autologous transplantation. When compared to the nonrituximab group, R patients were older (56 v 50 years; P < .001), and had delays in post-transplantation platelets recovery (39 v 27 days; P = .001). Pretransplantation R did not affect stem-cell mobilization, post-transplantation early complications, duration of hospitalization, or mortality rates at days 30 and 100. In contrast to patients with low-grade NHL, both disease-free and overall survival rates were significantly better when R was included in the pretransplantation salvage therapy for patients with intermediate-grade NHL. Conclusion In this large, single-center retrospective analysis, pretransplantation treatment with R was associated with improved survival in patients with intermediate-grade NHL, at the price, however, of a delay in platelet engraftment.

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