scholarly journals Prior immunosuppressive therapy with antithymocyte globulin increases the risk of EBV-related lymphoproliferative disorder following allo-SCT for acquired aplastic anaemia

2008 ◽  
Vol 43 (10) ◽  
pp. 813-816 ◽  
Author(s):  
H C E Buyck ◽  
S Ball ◽  
P Junagade ◽  
J Marsh ◽  
S Chakrabarti
Keyword(s):  
Immunosuppressive Therapy ◽  
Aplastic Anaemia ◽  
Lymphoproliferative Disorder ◽  
Antithymocyte Globulin

scholarly journals Colonic EBV-Associated Lymphoproliferative Disorder in a Patient Treated with Rabbit Antithymocyte Globulin for Aplastic Anemia

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Hiroko Sugimoto-Sekiguchi ◽  
Haruko Tashiro ◽  
Ryosuke Shirasaki ◽  
Tomio Arai ◽  
Tadashi Yamamoto ◽  
...  
Keyword(s):  
Viral Load ◽  
Aplastic Anemia ◽  
Immunosuppressive Therapy ◽  
Lymphoproliferative Disorder ◽  
Antithymocyte Globulin ◽  
White Blood Cells ◽  
Barr Virus ◽  
Rabbit Antithymocyte Globulin ◽  
Single Use ◽  
Epstein Barr

Epstein-Barr-virus- (EBV-) associated lymphoproliferative disorder (LPD) after immunosuppressive therapy for aplastic anemia (AA), in a nontransplant setting, has not been well described. We report one case of colonic EBV-LPD after a single course of immunosuppressive therapy for AA. The patient developed multiple colonic tumors 3 months after receiving immunosuppressive therapy, which consisted of rabbit antithymocyte globulin (ATG), cyclosporine, and methyl-predonisolone. The histological findings of biopsy specimens revealed that atypical lymphocytes had infiltrated colonic glands. Immunohistochemical staining for CD20 was positive, andin situhybridization for EBV-encoded small RNAs was also positive. The EBV viral load in peripheral blood was slightly increased to 140/106white blood cells. After the cessation of immunosuppressant, the colonic tumors spontaneously regressed, and the EBV viral load decreased to undetectable levels. This is the first report of the single use of rabbit ATG inducing colonic EBV-LPD. Because a single use of immunosuppressive therapy containing rabbit ATG can cause EBV-LPD, we should carefully observe patients receiving rabbit ATG for AA.

Antithymocyte globulin treatment of severe aplastic anaemia

1983 ◽  
Vol 55 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Wesley J. Miller ◽  
Richard F. Branda ◽  
Patrick J. Flynn ◽  
Robert B. Howe ◽  
Norma K. C. Ramsay ◽  
...  
Keyword(s):  
Aplastic Anaemia ◽  
Antithymocyte Globulin ◽  
Severe Aplastic Anaemia

The effectiveness of immunosuppressive therapy in patients with aplastic anaemia secondary to chemoradiotherapy for cancers

2021 ◽  
Author(s):  
Noriharu Nakagawa ◽  
Ken Ishiyama ◽  
Mikoto Tanabe ◽  
Takeshi Yoroidaka ◽  
Hiroki Mizumaki ◽  
...  
Keyword(s):  
Immunosuppressive Therapy ◽  
Aplastic Anaemia

scholarly journals Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood

Haematologica ◽  
2013 ◽  
Vol 99 (4) ◽  
pp. 656-663 ◽  
Author(s):  
A. Yoshimi ◽  
M. M. van den Heuvel-Eibrink ◽  
I. Baumann ◽  
S. Schwarz ◽  
I. Simonitsch-Klupp ◽  
...  
Keyword(s):  
Immunosuppressive Therapy ◽  
Antithymocyte Globulin ◽  
Rabbit Antithymocyte Globulin
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