scholarly journals Myeloablative chemotherapy with autologous stem cell rescue for Ewing sarcoma

2008 ◽  
Vol 42 (11) ◽  
pp. 761-761
Author(s):  
A L Gilman ◽  
J Oesterheld
Keyword(s):  
Stem Cell ◽  
Ewing Sarcoma ◽  
Stem Cell Rescue ◽  
Myeloablative Chemotherapy ◽  
Autologous Stem Cell Rescue

scholarly journals Myeloablative therapy with autologous stem cell rescue for patients with Ewing sarcoma

2008 ◽  
Vol 41 (10) ◽  
pp. 867-872 ◽  
Author(s):  
S L Gardner ◽  
J Carreras ◽  
C Boudreau ◽  
B M Camitta ◽  
R H Adams ◽  
...  
Keyword(s):  
Stem Cell ◽  
Ewing Sarcoma ◽  
Stem Cell Rescue ◽  
Autologous Stem Cell Rescue

Pilot Study of Iodine-131–Metaiodobenzylguanidine in Combination With Myeloablative Chemotherapy and Autologous Stem-Cell Support for the Treatment of Neuroblastoma

2002 ◽  
Vol 20 (8) ◽  
pp. 2142-2149 ◽  
Author(s):  
Gregory A. Yanik ◽  
John E. Levine ◽  
Katherine K. Matthay ◽  
James C. Sisson ◽  
Barry L. Shulkin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Pilot Study ◽  
Neuroblastoma Cells ◽  
Complete Response ◽  
Novel Therapy ◽  
Peripheral Blood Stem Cells ◽  
Hematopoietic Stem ◽  
Stem Cell Rescue ◽  
Myeloablative Chemotherapy ◽  
Iodine 131

PURPOSE: The survival for children with relapsed or metastatic neuroblastoma remains poor. More effective regimens with acceptable toxicity are required to improve prognosis. Iodine-131–metaiodobenzylguanidine (131I-MIBG) selectively targets radiation to catecholamine-producing cells, including neuroblastoma cells. A pilot study was performed to examine the feasibility of a novel regimen combining 131I-MIBG and myeloablative chemotherapy with autologous stem-cell rescue. PATIENTS AND METHODS: Twelve patients with neuroblastoma were treated after relapse (five patients) or after induction therapy (seven patients). Eight patients had metastatic and four had localized disease at the time of therapy. All patients received 131I-MIBG 12 mCi/kg on day −21, followed by carboplatin (1,500 mg/m2), etoposide (800 mg/m2), and melphalan (210 mg/m2) administered from day −7 to day −4. Autologous peripheral-blood stem cells or bone marrow were infused on day 0. Engraftment, toxicity, and response rates were evaluated. RESULTS: The 131I-MIBG infusion and myeloablative chemotherapy were both well tolerated. Grade 2 to 3 oral mucositis was the predominant nonhematopoietic toxicity, occurring in all patients. The median times to neutrophil (≥ 0.5 × 103/μL) and platelet (≥ 20 × 103/μL) engraftment were 10 and 28 days, respectively. For the eight patients treated with metastatic disease, three achieved complete response and two had partial responses by day 100 after transplantation. CONCLUSION: Treatment with 131I-MIBG in combination with myeloablative chemotherapy and hematopoietic stem-cell rescue is feasible with acceptable toxicity. Future study is warranted to examine the efficacy of this novel therapy.

High-dose chemotherapy with autologous stem cell rescue in breast cancer

1996 ◽  
Vol 37 (3) ◽  
pp. 277-289 ◽  
Author(s):  
Robert O. Dillman ◽  
Neil M. Barth ◽  
Shankar K. Nayak ◽  
Cristina DeLeon ◽  
Audrey O'Connor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
High Dose Chemotherapy ◽  
High Dose ◽  
Stem Cell Rescue ◽  
Autologous Stem Cell Rescue
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