scholarly journals Photodynamic therapy: novel third-generation photosensitizers one step closer?

2008 ◽  
Vol 154 (1) ◽  
pp. 1-3 ◽  
Author(s):  
L B Josefsen ◽  
R W Boyle
Keyword(s):  
Photodynamic Therapy ◽  
Third Generation ◽  
One Step

Effective Monofunctional Azaphthalocyanine Photosensitizers for Photodynamic Therapy

2009 ◽  
Vol 62 (5) ◽  
pp. 425 ◽  
Author(s):  
Petr Zimcik ◽  
Miroslav Miletin ◽  
Veronika Novakova ◽  
Kamil Kopecky ◽  
Marcela Nejedla ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Carboxy Group ◽  
Rational Design ◽  
Photophysical Properties ◽  
Active Part ◽  
Third Generation ◽  
Highly Active ◽  
Low Degree ◽  
Band Absorption ◽  
Group B

In this work we present a rational design of the active part of third generation photosensitizers for photodynamic therapy based on phthalocyanine and an azaphthalocyanine core. The preferred zinc complexes of the AAAB type that contain bulky tert-butylsulfanyl substituents (A) and one carboxy group (B) have been synthesized by statistical condensation and fully characterized. The tetramerization was performed using magnesium(ii) butoxide followed by demetalation and insertion of ZnII. Compound 1 synthesized from 4,5-bis(tert-butylsulfanyl)phthalonitrile (A) and 2,3-dicyanoquinoxaline-6-carboxylic acid (B) exerted very promising photophysical properties (Q-band absorption at 726 nm, ϵ = 140000 M–1 cm–1), which allowed strong absorption of light at long wavelengths where the penetration of the light through human tissues is deeper. The very high singlet oxygen quantum yield of 1 (ΦΔ = 0.80) assures efficient photosensitization. As a result of bulky peripheral substituents, compound 1 shows good solubility in organic solvents with a low degree of aggregation, which makes it potentially viable for non-complicated modification. One carboxy group in the final structure of 1 allows simple binding to possible carriers. This compound is suitable for binding to targeting moieties to form the highly active part of a third-generation photosensitizer.

One-step co-assembly method to fabricate photosensitive peptide nanoparticles for two-photon photodynamic therapy

2019 ◽  
Vol 55 (22) ◽  
pp. 3191-3194 ◽  
Author(s):  
Jieling Li ◽  
Anhe Wang ◽  
Peng Ren ◽  
Xuehai Yan ◽  
Shuo Bai
Keyword(s):  
Photodynamic Therapy ◽  
Two Photon ◽  
Assembly Method ◽  
One Step ◽  
Peptide Nanoparticles

Peptide-based nanoparticles were employed to load and disperse hydrophobic porphyrins through a one-step co-assembly method for two-photon photodynamic therapy.

Water-soluble hyperbranched polyglycerol photosensitizer for enhanced photodynamic therapy

2020 ◽  
Vol 11 (23) ◽  
pp. 3913-3921
Author(s):  
Bowen Xiang ◽  
Yudong Xue ◽  
Zhiyong Liu ◽  
Jia Tian ◽  
Holger Frey ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble ◽  
One Step ◽  
New Type ◽  
Hyperbranched Polyglycerol

Herein, we successfully fabricated a new type of water-soluble, hyperbranched polyglycerol photosensitizer through one-step esterification between water-soluble hyperbranched polyglycerol (hbPG) and fluorophenylporphyrin (FP).

Synthesis, photophysical and photobiological characterization of BSA nanoparticles loaded with chloroaluminium phthalocyanine by one-step desolvation technique for photodynamic therapy action

2019 ◽  
Vol 30 (16) ◽  
pp. 1559-1573 ◽  
Author(s):  
Alexandro da Silva Abreu ◽  
Janicy Arantes Carvalho ◽  
Agnes Cecheto Trindade ◽  
Milton Beltrame Junior ◽  
Andreza Ribeiro Simioni
Keyword(s):  
Photodynamic Therapy ◽  
One Step

One-Step Self-Assembly of ZnPc/KMnF3: Yb, Er upconversion Photodynamic Therapy System for Antibacterial Applications

NANO ◽  
2020 ◽  
Vol 15 (06) ◽  
pp. 2050075
Author(s):  
Xingqi Zhu ◽  
Deshuai Zhen ◽  
Chenyi Li ◽  
Ning Jiang ◽  
Hongchao Geng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Multidrug Resistant ◽  
Water Soluble ◽  
Confocal Imaging ◽  
Zinc Phthalocyanine ◽  
Great Promise ◽  
Oxygen Species ◽  
Gram Positive Bacteria ◽  
One Step

Photodynamic therapy (PDT) holds great promise as an effective approach to kill multidrug resistant (MDR) bacteria. In this study, KMnF3:Yb,Er upconversion nanoparticles (UCNPs) were prepared and modified with zinc phthalocyanine (ZnPc), a photosensitizer with a major absorption band at 670[Formula: see text]nm. ZnPc absorbs the emission at 660[Formula: see text]nm of the UCNPs producing reactive oxygen species (ROS) which kill the surrounding bacteria. The UCNPs were also modified with Tween to make them water-soluble and biocompatible, and oleylamine to provide positive charges to shorten the distance from bacteria. Detection of singlet oxygen production, bacteria viability test and confocal imaging were performed, respectively. The as-prepared system (UCNPs@ZnPc@Tween) shows enhanced efficiency of PDT against both Gram-negative and Gram-positive bacteria.

Preparation, Characterization and Phototoxicity of Photosan-Loaded Hollow Silica Nanospheres for Photodynamic Therapy

2012 ◽  
Vol 622-623 ◽  
pp. 930-938
Author(s):  
Xiao Feng Deng ◽  
Yu Wen ◽  
Liang Wu Lin ◽  
Li Xiong ◽  
Xiong Ying Miao
Keyword(s):  
Photodynamic Therapy ◽  
Culture Medium ◽  
Red Light ◽  
Light Dose ◽  
Silica Nanospheres ◽  
Hollow Silica ◽  
One Step ◽  
Wet Chemical ◽  
Hollow Silica Nanospheres ◽  
Phosphate Buffered Saline

In this study, Photosan (PS) was loaded onto hollow silica nanospheres using one-step wet chemical-based synthetic route method. Polydispersive index of the Photosan-loaded hollow Silica Nanospheres (PS-loaded NSs) is 0.121±0.01. The photobiological activity of the PS-loaded NSs was evaluated on human cholangiocarcinoma QBC939 cells. Cells were incubated with free PS or PS-loaded NSs for 2 h and then washed with phosphate-buffered saline. Culture medium was added to the wells containing the cells. Finally, the cells were exposed to red light (630 nm) with a light dose of 10J/cm2. The cellular viability was determined after 24 h of incubation. PS-loaded NSs and free PS eliminated about 96.4%±2.0% and 54.7%±1.9% of QBC939 cells, respectively. The phototoxicity was time dependent up to 2 h and concentration dependent at 1-7.5 mg/l. The cells viability decreased with the increase of the light dose in the range of 5-15 J/cm2. In conclusion, PS-loaded NSs are the release systems that promise photodynamic therapy use.

Features of third generation photosensitizers used in anticancer photodynamic therapy: Review

2021 ◽  
Vol 34 ◽  
pp. 102091
Author(s):  
Ivan S. Mfouo-Tynga ◽  
Lucas D. Dias ◽  
Natalia M. Inada ◽  
Cristina Kurachi
Keyword(s):  
Photodynamic Therapy ◽  
Third Generation

Maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility

2016 ◽  
Vol 14 (14) ◽  
pp. 3608-3613 ◽  
Author(s):  
Atsushi Narumi ◽  
Takahiro Tsuji ◽  
Kosuke Shinohara ◽  
Hiromi Yamazaki ◽  
Moriya Kikuchi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Solubility ◽  
Third Generation ◽  
Chlorin Derivative

A chlorin derivative was encircled with four maltotriose (Mal3) molecules to produce an oligosaccharide-conjugate meeting the requirements of a third generation photodynamic therapy (PDT) photosensitizer.

One-Step Preparation of a Water-Soluble Carbon Nanohorn/Phthalocyanine Hybrid for Dual-Modality Photothermal and Photodynamic Therapy

2014 ◽  
Vol 6 (20) ◽  
pp. 18008-18017 ◽  
Author(s):  
Bang-Ping Jiang ◽  
Lan-Fang Hu ◽  
Xing-Can Shen ◽  
Shi-Chen Ji ◽  
Zujin Shi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble ◽  
Dual Modality ◽  
One Step ◽  
Soluble Carbon
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