scholarly journals Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell-dependent stimulation of Jurkat T cells

2008 ◽  
Vol 155 (7) ◽  
pp. 1076-1084 ◽  
Author(s):  
D Kempuraj ◽  
M Tagen ◽  
B P Iliopoulou ◽  
A Clemons ◽  
M Vasiadi ◽  
...  
Keyword(s):  
T Cells ◽  
Mast Cell ◽  
Myelin Basic Protein ◽  
Cell Activation ◽  
Basic Protein ◽  
Mast Cell Activation ◽  
Human Mast Cell ◽  
Jurkat T Cells ◽  
Stimulation Of

scholarly journals Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation

2015 ◽  
Vol 212 (13) ◽  
pp. 2289-2304 ◽  
Author(s):  
Binh L. Phong ◽  
Lyndsay Avery ◽  
Tina L. Sumpter ◽  
Jacob V. Gorman ◽  
Simon C. Watkins ◽  
...  
Keyword(s):  
T Cells ◽  
Mast Cell ◽  
Signaling Pathways ◽  
Cell Activation ◽  
Molecular Mechanisms ◽  
Late Phase ◽  
Cell Types ◽  
Mast Cell Activation ◽  
Positive Role ◽  
Ample Evidence

T cell (or transmembrane) immunoglobulin and mucin domain protein 3 (Tim-3) has attracted significant attention as a novel immune checkpoint receptor (ICR) on chronically stimulated, often dysfunctional, T cells. Antibodies to Tim-3 can enhance antiviral and antitumor immune responses. Tim-3 is also constitutively expressed by mast cells, NK cells and specific subsets of macrophages and dendritic cells. There is ample evidence for a positive role for Tim-3 in these latter cell types, which is at odds with the model of Tim-3 as an inhibitory molecule on T cells. At this point, little is known about the molecular mechanisms by which Tim-3 regulates the function of T cells or other cell types. We have focused on defining the effects of Tim-3 ligation on mast cell activation, as these cells constitutively express Tim-3 and are activated through an ITAM-containing receptor for IgE (FcεRI), using signaling pathways analogous to those in T cells. Using a variety of gain- and loss-of-function approaches, we find that Tim-3 acts at a receptor-proximal point to enhance Lyn kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcεRI ligation.

scholarly journals Human mast cell activation through Fc receptors and Toll-like receptors

2004 ◽  
Vol 53 (3) ◽  
pp. 227-233 ◽  
Author(s):  
Yoshimichi Okayama ◽  
Shigeru Okumura ◽  
Hisashi Tomita ◽  
Hiroko Katayama ◽  
Keisuke Yuki ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Fc Receptors ◽  
Mast Cell Activation ◽  
Human Mast Cell ◽  
Toll Like Receptors

scholarly journals Foxp3+ Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice

2014 ◽  
Vol 10 (2) ◽  
pp. e1003913 ◽  
Author(s):  
Birte Blankenhaus ◽  
Martina Reitz ◽  
Yannick Brenz ◽  
Marie-Luise Eschbach ◽  
Wiebke Hartmann ◽  
...  
Keyword(s):  
T Cells ◽  
Mast Cell ◽  
Regulatory T Cells ◽  
Cell Activation ◽  
Mast Cell Activation

scholarly journals Granzyme D Is a Novel Murine Mast Cell Protease That Is Highly Induced by Multiple Pathways of Mast Cell Activation

2013 ◽  
Vol 81 (6) ◽  
pp. 2085-2094 ◽  
Author(s):  
Elin Rönnberg ◽  
Gabriela Calounova ◽  
Bengt Guss ◽  
Anders Lundequist ◽  
Gunnar Pejler
Keyword(s):  
T Cells ◽  
Mast Cell ◽  
Mast Cells ◽  
Serine Proteases ◽  
Cell Activation ◽  
Calcium Ionophore ◽  
Mast Cell Activation ◽  
Activated T Cells ◽  
Mast Cell Protease ◽  
Murine Mast Cell

ABSTRACTGranzymes are serine proteases known mostly for their role in the induction of apoptosis. Granzymes A and B have been extensively studied, but relatively little is known about granzymes C to G and K to M. T cells, lymphohematopoietic stromal cells, and granulated metrial gland cells express granzyme D, but the function of granzyme D is unknown. Here we show that granzyme D is expressed by murine mast cells and that its level of expression correlates positively with the extent of mast cell maturation. Coculture of mast cells with live, Gram-positive bacteria caused a profound, Toll-like receptor 2 (TLR2)-dependent induction of granzyme D expression. Granzyme D expression was also induced by isolated bacterial cell wall components, including lipopolysaccharide (LPS) and peptidoglycan, and by stem cell factor, IgE receptor cross-linking, and calcium ionophore stimulation. Granzyme D was released into the medium in response to mast cell activation. Granzyme D induction was dependent on protein kinase C and nuclear factor of activated T cells (NFAT). Together, these findings identify granzyme D as a novel murine mast cell protease and implicate granzyme D in settings where mast cells are activated, such as bacterial infection and allergy.

scholarly journals Alpha7-nicotinic acetylcholine receptors involve the imidacloprid-induced inhibition of IgE-mediated rat and human mast cell activation

RSC Advances ◽  
2017 ◽  
Vol 7 (82) ◽  
pp. 51896-51906 ◽  
Author(s):  
Linbo Shi ◽  
Huaping Xu ◽  
Yujie Wu ◽  
Xin Li ◽  
Li Zou ◽  
...  
Keyword(s):  
Mast Cell ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Human Mast Cell ◽  
Inhibition Mechanism ◽  
Nicotinic Acetylcholine ◽  
Neonicotinoid Insecticide ◽  
Ige Mediated

Although our recent study indicated that imidacloprid, a widely used neonicotinoid insecticide, inhibited IgE-mediated mast cell activation, the inhibition mechanism still remains unclear.

scholarly journals Modulation of host defense peptide-mediated human mast cell activation by LPS

2015 ◽  
Vol 22 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Kshitij Gupta ◽  
Hariharan Subramanian ◽  
Hydar Ali
Keyword(s):  
Mast Cell ◽  
Host Defense ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Human Mast Cell ◽  
Host Defense Peptide

Essential roles of sphingosine-1–phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema

2010 ◽  
Vol 188 (5) ◽  
pp. i10-i10
Author(s):  
Carole A. Oskeritzian ◽  
Megan M. Price ◽  
Nitai C. Hait ◽  
Dmitri Kapitonov ◽  
Yves T. Falanga ◽  
...  
Keyword(s):  
Mast Cell ◽  
Pulmonary Edema ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Human Mast Cell ◽  
Sphingosine 1 Phosphate

Platelet activation responses in vitro to human mast cell activation

1999 ◽  
Vol 106 (1) ◽  
pp. 208-215 ◽  
Author(s):  
Gardiner ◽  
Harrison ◽  
Chavda ◽  
Mackie ◽  
Machin
Keyword(s):  
Mast Cell ◽  
Platelet Activation ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Human Mast Cell

A new chemical tool (C0036E08) supports the role of adenosine A2B receptors in mediating human mast cell activation

2008 ◽  
Vol 76 (7) ◽  
pp. 912-921 ◽  
Author(s):  
Montserrat Buceta ◽  
Eduardo Domínguez ◽  
Marián Castro ◽  
José Brea ◽  
David Álvarez ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Human Mast Cell ◽  
Adenosine A2b
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