scholarly journals Intrapulmonary and intravenous administrations of dihydroergotamine mesylate have similar cardiovascular effects in the conscious dog

2008 ◽  
Vol 154 (6) ◽  
pp. 1254-1265 ◽  
Author(s):  
S B Shrewsbury ◽  
M Stonerook ◽  
J K Okikawa
Keyword(s):  
Cardiovascular Effects ◽  
Conscious Dog ◽  
Dihydroergotamine Mesylate

Central cardiovascular effects of tacrine in the conscious dog: a role for catecholamines and vasopressin release

1998 ◽  
Vol 348 (2-3) ◽  
pp. 191-198 ◽  
Author(s):  
Cuider Allal ◽  
Eric Lazartigues ◽  
Marie-Antoinette Tran ◽  
Christine Brefel-Courbon ◽  
Claude Gharib ◽  
...  
Keyword(s):  
Cardiovascular Effects ◽  
Vasopressin Release ◽  
Conscious Dog

scholarly journals Lipomobilizing effects of procaterol and yohimbine in the conscious dog: comparison of endocrinological, metabolic and cardiovascular effects

1989 ◽  
Vol 97 (1) ◽  
pp. 229-239 ◽  
Author(s):  
Philippe Valet ◽  
Mohammed Taouis ◽  
Marie A. Tran ◽  
Paul Montastruc ◽  
Max Lafontan ◽  
...  
Keyword(s):  
Cardiovascular Effects ◽  
Conscious Dog

Cetamolol: cardiovascular effects of a new cardioselective β-adrenoceptor blocker possessing partial agonistic activity and lacking membrane-stabilizing activity

1984 ◽  
Vol 62 (6) ◽  
pp. 610-616 ◽  
Author(s):  
G. Beaulieu ◽  
D. Grimes ◽  
C. Muirhead ◽  
G. Oshiro
Keyword(s):  
Cardiovascular Effects ◽  
Peak Effect ◽  
Moderate Degree ◽  
Closed Chest ◽  
Conscious Dog ◽  
In Vivo Experiments ◽  
Adrenoceptor Blocker ◽  
Agonistic Activity ◽  
Β Blocker

The cardiovascular effects of cetamolol, a new β-adrenoceptor blocker, were studied in the anesthetized dog and cat and in the conscious dog and monkey. The compound was compared with other β-blockers known to possess various degrees of cardioselectivity, partial agonistic effects, and membrane-stabilizing activity. In the anesthetized open-chest dog, cetamolol and pindolol produced similar cardiovascular effects in that the partial agonistic activity predominated over the blockade of β-adrenoceptors. The partial agonistic activity of pindolol was greater than that of cetamolol. Unlike pindolol, cetamolol had no significant vasodilating property. However, the β-blocking effects of these two drugs predominated in the anesthetized closed-chest dog, conscious dog and monkey. Atenolol, nadolol, and propranolol, which lack partial agonistic activity, produced cardiovascular changes characteristic of this type of β-blocker in the animal preparation in which they were tested. In the anesthetized cat, comparison of the mean effective doses for the heart rate and blood pressure responses induced by isoproterenol showed that cetamolol was more cardioselective than metoprolol but less than acebutolol and atenolol. Evidence of the cardioselectivity of cetamolol was also obtained in the anesthetized closed-chest dog, although the degree of cardioselectivity of both cetamolol and atenolol was less marked than in the cat. When given orally to the conscious dog and monkey, cetamolol appeared to be well absorbed. The peak effect was observed after 1 – 2 h and persisted for the 5-h test period. It is concluded that cetamolol is a potent β-blocker with a moderate degree of partial agonistic activity and cardioselectivity in in vivo experiments.

Cardiovascular effects of nicotine in the conscious dog

1973 ◽  
Vol 32 (7) ◽  
pp. 947-955 ◽  
Author(s):  
William J. Mandel ◽  
Michael Laks ◽  
Hirokazu Hayakawa ◽  
Kanji Obayashi ◽  
Avile McCullen
Keyword(s):  
Cardiovascular Effects ◽  
Conscious Dog

Reflex cardiovascular effects of intracoronary acetylstrophanthidin in the conscious dog

1985 ◽  
Vol 248 (6) ◽  
pp. H930-H936
Author(s):  
K. W. Barron ◽  
V. S. Bishop
Keyword(s):  
Receptor Antagonist ◽  
Adrenergic Receptor ◽  
Cardiovascular Effects ◽  
Left Ventricular ◽  
Vagal Afferents ◽  
Circumflex Coronary Artery ◽  
Inotropic Effects ◽  
Conscious Dog ◽  
Intracoronary Administration ◽  
Positive Inotropic Effects

The present experiments were designed to examine the reflex cardiovascular effects of intracoronary administration of acetylstrophanthidin in the conscious dog. Administration of 4 micrograms/kg of this agent into the left circumflex coronary artery increased left ventricular dP/dtmax but had no effect on mean arterial pressure, heart rate, renal resistance, or iliac resistance. The positive inotropic effects of acetylstrophanthidin were less under control conditions (+599 mmHg/s) than during bilateral cervical vagal cold block (+850 mmHg/s, P less than 0.05); however, interruption of vagal efferent influences (atropine) alone did not alter the contractile effects of acetylstrophanthidin. Interruption of sympathetic efferent influences on the heart with either the nicotinic ganglionic receptor antagonist, hexamethonium, or the beta 1-adrenergic receptor antagonist, metoprolol, also augmented the inotropic effects of acetylstrophanthidin to a degree similar to that observed with vagal cold block. In contrast to the effects observed with acetylstrophanthidin, the inotropic effects of intracoronary administration of calcium gluconate were not altered by vagal cold block or any other conditions examined in this study. We conclude that interruption of vagal afferents results in an augmentation of the positive inotropic actions of acetylstrophanthidin and that this augmented inotropic effect can be accounted for by interruption of cardiac vagal afferent-mediated restraint on sympathetic outflow to the heart.

Cardiovascular effects of apraclonidine in the conscious dog

1993 ◽  
Vol 28 (2) ◽  
pp. 161-168
Author(s):  
Carl E. Jones ◽  
Verney Sallee ◽  
Louis DeSantis ◽  
Pamela A. Gayheart ◽  
Melissa L. Hamrick ◽  
...  
Keyword(s):  
Cardiovascular Effects ◽  
Conscious Dog

scholarly journals Central cardiovascular effects of acetylcholine in the conscious dog

1995 ◽  
Vol 116 (4) ◽  
pp. 2175-2182 ◽  
Author(s):  
C. Brefel ◽  
E. Lazartigues ◽  
M.A. Tran ◽  
G. Gauquelin ◽  
G. Geelen ◽  
...  
Keyword(s):  
Cardiovascular Effects ◽  
Conscious Dog

Cardiovascular Effects of the Nifedipine Analog, CGP 28 392, in the Conscious Dog

1984 ◽  
Vol 6 (5) ◽  
pp. 949-953 ◽  
Author(s):  
Kevin C. Preuss ◽  
Norman L. Cheung ◽  
Harold L. Brooks ◽  
David C. Warltier
Keyword(s):  
Cardiovascular Effects ◽  
Conscious Dog
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