scholarly journals The μ-opioid receptor agonist morphine, but not agonists at δ- or κ-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors

2008 ◽  
Vol 154 (5) ◽  
pp. 1143-1149 ◽  
Author(s):  
D Da Fonseca Pacheco ◽  
A Klein ◽  
A De Castro Perez ◽  
C M Da Fonseca Pacheco ◽  
J N De Francischi ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Opioid Receptors ◽  
Receptor Agonist ◽  
Cannabinoid Receptors ◽  
Opioid Receptor Agonist ◽  
Μ Opioid Receptor

An antisense oligodeoxynucleotide to μ-opioid receptors inhibits μ-opioid receptor agonist-induced analgesia in rats

1995 ◽  
Vol 275 (1) ◽  
pp. 105-108 ◽  
Author(s):  
Xiao-Hong Chen ◽  
Jill U. Adams ◽  
Ellen B. Geller ◽  
J.Kim DeRiel ◽  
Martin W. Adler ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Opioid Receptors ◽  
Receptor Agonist ◽  
Antisense Oligodeoxynucleotide ◽  
Opioid Receptor Agonist ◽  
Μ Opioid Receptor ◽  
Μ Opioid Receptors

scholarly journals Four stereoisomers of the novel μ-opioid receptor agonist tapentadol hydrochloride

2011 ◽  
Vol 67 (2) ◽  
pp. o71-o76 ◽  
Author(s):  
Krishnan Ravikumar ◽  
Balasubramanian Sridhar ◽  
Nitin Pradhan ◽  
Mayur Khunt
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
The Novel ◽  
Opioid Receptor Agonist ◽  
Μ Opioid Receptor

scholarly journals Analgesic effects of a novel pH-dependent μ-opioid receptor agonist in models of neuropathic and abdominal pain

Pain ◽  
2018 ◽  
Vol 159 (11) ◽  
pp. 2277-2284 ◽  
Author(s):  
Antonio Rodriguez-Gaztelumendi ◽  
Viola Spahn ◽  
Dominika Labuz ◽  
Halina Machelska ◽  
Christoph Stein
Keyword(s):  
Abdominal Pain ◽  
Opioid Receptor ◽  
Receptor Agonist ◽  
Analgesic Effects ◽  
Opioid Receptor Agonist ◽  
Μ Opioid Receptor ◽  
Ph Dependent

Effects of an opioid receptor agonist and antagonist on cytokine-stimulated canine articular chondrocytes in three-dimensional culture

2002 ◽  
Vol 15 (02) ◽  
pp. 72-77
Author(s):  
J. L. Cook ◽  
J. R. Dodam ◽  
J. M. Kreeger ◽  
J. L. Tomlinson ◽  
K. Kuroki ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
Articular Chondrocytes ◽  
Interleukin 1 ◽  
Three Dimensional ◽  
Culture Liquid ◽  
Pge2 Production ◽  
Opioid Receptor Agonist ◽  
Agonist And Antagonist ◽  
Μ Opioid Receptor

SummaryThe objective of this study was to evaluate the effects of [D-Ala2, Nme-Phe4, Gly5-ol] enkephalin (DAMGO), a μ-opioid receptor agonist, and β-funaltrexamine (β-FNA), a μ-opioid receptor antagonist, on the biosynthetic capabilities of canine chondrocytes cultured in the presence of interleukin-1 β (IL-1 β). Articular chondrocytes were harvested from the humeral heads of three adult dogs and cultured in a three-dimensional (3-D) gel medium made from low-melting agarose and cell culture medium. Chondrocytes in 3-D culture were exposed to IL-1 β (0 or 20 ng/ml), DAMGO (0,0.1,1.0, or 10 μM), and β-FNA (0 or 10 μM) by addition to the liquid media in all possible combinations. On days five and 15 of 3-D culture, liquid medium samples were harvested for subsequent analysis of glycosaminogly- can (GAG), prostaglandin E2 (PGE2) and matrix metalloprotease-3 (MMP-3) content. On the same days, gel plugs were also harvested and evaluated for GAG content.Incubation with IL-1 β decreased the amount of GAG in the gel plugs and caused an increase in PGE2 production on days five and 15 of 3-D culture. Treatment with DAMGO or β-FNA did not significantly modulate PGE2 production, MMP-3 production, GAG loss to the medium or GAG content of the gel plugs on either day five or 15 of 3-D culture in the presence or absence of IL-1 β. We concluded that DAMGO and β-FNA had neither protective nor detrimental effects on the biosynthetic capabilities of chondrocytes in the presence or absence of IL-1 β.

In VitroBinding and Signaling Profile of the Novel μ Opioid Receptor Agonist Endomorphin 2 in Rat Brain Membranes

1998 ◽  
Vol 250 (3) ◽  
pp. 720-725 ◽  
Author(s):  
Mariana Spetea ◽  
Krisztina Monory ◽  
Csaba Tömböly ◽  
Géza Tóth ◽  
Eleni Tzavara ◽  
...  
Keyword(s):  
Rat Brain ◽  
Opioid Receptor ◽  
Receptor Agonist ◽  
The Novel ◽  
Brain Membranes ◽  
Opioid Receptor Agonist ◽  
Rat Brain Membranes ◽  
Μ Opioid Receptor
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