scholarly journals Erratum: Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

2018 ◽  
Vol 118 (6) ◽  
pp. e9-e9 ◽  
Author(s):  
Edward J Saunders ◽  
◽  
Tokhir Dadaev ◽  
Daniel A Leongamornlert ◽  
Ali Amin Al Olama ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Cancer Susceptibility ◽  
Gene Variants ◽  
Repair Gene ◽  
Genotyping Array ◽  
Prostate Cancer Susceptibility ◽  
Dna Repair Gene ◽  
Pathway Level

scholarly journals Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

2016 ◽  
Vol 114 (8) ◽  
pp. 945-952 ◽  
Author(s):  
Edward J Saunders ◽  
◽  
Tokhir Dadaev ◽  
Daniel A Leongamornlert ◽  
Ali Amin Al Olama ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Cancer Susceptibility ◽  
Association Studies ◽  
Fanconi Anaemia ◽  
Genome Wide Association Studies ◽  
Dna Repair Genes ◽  
Dna Repair Gene ◽  
Repair Genes ◽  
Pathway Level

Abstract Background: Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of ∼100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wide association studies implicate RAD51B and RAD23B. Methods: Genotype data from the iCOGS array were imputed to the 1000 genomes phase 3 reference panel for 21 780 PrCa cases and 21 727 controls from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. We subsequently performed single variant, gene and pathway-level analyses using 81 303 SNPs within 20 Kb of a panel of 179 DNA-repair genes. Results: Single SNP analyses identified only the previously reported association with RAD51B. Gene-level analyses using the SKAT-C test from the SNP-set (Sequence) Kernel Association Test (SKAT) identified a significant association with PrCa for MSH5. Pathway-level analyses suggested a possible role for the translesion synthesis pathway in PrCa risk and Homologous recombination/Fanconi Anaemia pathway for PrCa aggressiveness, even though after adjustment for multiple testing these did not remain significant. Conclusions: MSH5 is a novel candidate gene warranting additional follow-up as a prospective PrCa-risk locus. MSH5 has previously been reported as a pleiotropic susceptibility locus for lung, colorectal and serous ovarian cancers.

Concordance of DNA Repair Gene Mutations in Paired Primary Prostate Cancer Samples and Metastatic Tissue or Cell-Free DNA

JAMA Oncology ◽  
2021 ◽  
Author(s):  
Michael T. Schweizer ◽  
Smruthy Sivakumar ◽  
Hanna Tukachinsky ◽  
Ilsa Coleman ◽  
Navonil De Sarkar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Gene Mutations ◽  
Repair Gene ◽  
Cell Free Dna ◽  
Metastatic Tissue ◽  
Free Dna ◽  
Primary Prostate Cancer ◽  
Dna Repair Gene

DNA repair gene variants in endometrial carcinoma

2012 ◽  
Vol 29 (4) ◽  
pp. 2949-2954 ◽  
Author(s):  
Zeynep Birsu Cincin ◽  
Ahmet Cem Iyibozkurt ◽  
Sibel Bulgurcuoglu Kuran ◽  
Bedia Cakmakoglu
Keyword(s):  
Dna Repair ◽  
Endometrial Carcinoma ◽  
Gene Variants ◽  
Repair Gene ◽  
Dna Repair Gene

Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells

2011 ◽  
Vol 28 (10) ◽  
pp. 579-587 ◽  
Author(s):  
Kuo-Ching Liu ◽  
Heng-Chien Ho ◽  
An-Cheng Huang ◽  
Bin-Chuan Ji ◽  
Hui-Yi Lin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Dna Damage ◽  
Dna Repair ◽  
Gallic Acid ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Repair Gene ◽  
Dna Repair Gene

Abstract 2636: Nonmelanoma skin cancer as a marker of a cancer-prone phenotype: Potential role of DNA repair gene variants

2012 ◽  
Author(s):  
Ingo Ruczinski ◽  
Timothy Jorgensen ◽  
Yin Yao Shugart ◽  
Yvette Berthier-Schaad ◽  
Bailey Kessing ◽  
...  
Keyword(s):  
Dna Repair ◽  
Skin Cancer ◽  
Potential Role ◽  
Nonmelanoma Skin Cancer ◽  
Gene Variants ◽  
Repair Gene ◽  
Dna Repair Gene
Sign in / Sign up

Export Citation Format

Share Document