scholarly journals Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study

2017 ◽  
Vol 117 (8) ◽  
pp. 1233-1240 ◽  
Author(s):  
Reina Haque ◽  
Marianne UlcickasYood ◽  
Xiaoqing Xu ◽  
Andrea E Cassidy-Bushrow ◽  
Huei-Ting Tsai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cardiovascular Disease ◽  
Cohort Study ◽  
Androgen Deprivation Therapy ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Androgen Deprivation

scholarly journals Patient Anxiety About Prostate Cancer Independently Predicts Early Initiation of Androgen Deprivation Therapy for Biochemical Cancer Recurrence in Older Men: A Prospective Cohort Study

2009 ◽  
Vol 27 (10) ◽  
pp. 1557-1563 ◽  
Author(s):  
William Dale ◽  
Joshua Hemmerich ◽  
Kathryn Bylow ◽  
Supriya Mohile ◽  
Mary Mullaney ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
Androgen Deprivation Therapy ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Older Patients ◽  
Older Men ◽  
Androgen Deprivation ◽  
Early Initiation ◽  
Optimal Timing

Purpose Androgen deprivation therapy (ADT) is first-line therapy for patients with prostate cancer (PCA) who experience biochemical recurrence (BCR). However, the optimal timing of ADT initiation is uncertain, and earlier ADT initiation can cause toxicities that lower quality of life (QOL). We tested the hypothesis that elevated cancer anxiety leads to earlier ADT initiation for BCR in older men. Patients and Methods We conducted a prospective cohort study of older patients with BCR of PCA (n = 67). Patients completed questionnaires at presentation and each follow-up visit until initiation of ADT. PCA-specific anxiety was measured with the Memorial Anxiety Scale for Prostate Cancer (MAX-PC). Other collected data included demographics, clinical information, and general anxiety information. Treating oncologists were surveyed about their recommendations for ADT initiation. The primary outcome was the time to ADT initiation. Univariate, multivariate logistic regression, and time-to-event analyses were conducted to evaluate whether cancer anxiety was a predictor of earlier initiation of ADT. Results Thirty-three percent of patients initiated ADT at the first or second clinic visit. Elevated PCA anxiety (MAX-PC > 16) was the most robust predictor in multivariate analyses of early initiation (odds ratio [OR], 9.19; P = .01). PSA also independently correlated with early initiation (OR, 1.31; P = .01). PSA did not correlate with MAX-PC. Conclusion Cancer anxiety independently and robustly predicts earlier ADT initiation in older men with BCR. For older patients with PCA, earlier ADT initiation may not change life expectancy and can negatively impact QOL. PCA-specific anxiety is a potential target for a decision-making intervention in this setting.

scholarly journals Cardiovascular disease risk scores in identifying future frailty: the Whitehall II prospective cohort study

Heart ◽  
2013 ◽  
Vol 99 (10) ◽  
pp. 737-742 ◽  
Author(s):  
Kim Bouillon ◽  
G David Batty ◽  
Mark Hamer ◽  
Severine Sabia ◽  
Martin J Shipley ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Risk Scores

scholarly journals Retinopathy Signs Improved Prediction and Reclassification of Cardiovascular Disease Risk in Diabetes: A prospective cohort study

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Henrietta Ho ◽  
Carol Y. Cheung ◽  
Charumathi Sabanayagam ◽  
Wanfen Yip ◽  
Mohammad Kamran Ikram ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Disease Risk ◽  
Cardiovascular Disease Risk
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