scholarly journals Lung cancer prognostic index: a risk score to predict overall survival after the diagnosis of non-small-cell lung cancer

2017 ◽  
Vol 117 (5) ◽  
pp. 744-751 ◽  
Author(s):  
Marliese Alexander ◽  
Rory Wolfe ◽  
David Ball ◽  
Matthew Conron ◽  
Robert G Stirling ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Small Cell Lung Cancer ◽  
Risk Score ◽  
Cell Lung Cancer ◽  
Prognostic Index ◽  
Small Cell ◽  
Small Cell Lung

The relation between neutrophil lymphocyte ratio and survival in patients with small cell lung cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e18516-e18516
Author(s):  
Mevlude Inanc ◽  
Oktay Bozkurt ◽  
Melih Kiziltepe ◽  
Halit Karaca ◽  
Veli Berk ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Prognostic Index ◽  
Small Cell ◽  
Small Cell Lung ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
The Relationship

e18516 Background: Neutrophil-lymphocyte ratio (NLR) is not an only inflammation marker, but also used as a prognostic index of various malignancies. Small cell lung cancer (SCLC) is considered metastatic at time of diagnosis, and survival is quite short. There is no any study evaluating the relationship between NLR and survival in SCLC. In this study, we aimed to determine the effect of NLR on overall survival. Methods: The study included 200 patients with SCLC. Survival times of patients, clinicopathological data and the results of a complete blood count at diagnosis were evaluated from patient archive files retrospectively. Patients were randomized into two groups according to NLR 5< or 5≥. Results: The median age of patients was 56 (36-80) years. One hundred and eighty one (90.5%) patients were male and 19 (9.5%) were males. Sixty-eight (34%) patients had dyspnea, 36 (18%) of cases had cough, 22 (11%) patients had back pain, and 14 (7%) of the cases had chest pain. While the duration of symptoms longer than 3 months in 90 (45%) patients, 110 (55%) patients had symptoms shorter than 3 months. Seventy-two (36%) patients had limited disease, 128 (64%) patients had extensive disease at the time of diagnosis. Twenty-one (10.5%) patients had brain metastasis initially. The median neutrophil count was 5.46 (1.02-20.2) 103 µl, and the median lymphocyte 1.69 (0.27 to 21.9) 103 µl, and median NLR was 3.19 (0.04 to 37.63) respectively. NLR overall survival rate was lowering in patients with greater than or equal to 5 group (5 ≥ group=7 months, 5< group=10 months) (p = 0.004). Conclusions: NLR is an important prognostic index that emphasis on the relationship between cancer and host in SCLC. However, a blood test is cheap and easy to use. This study was concluded that survival was shorter in patients with NLR ≥ 5 in SCLC.

scholarly journals A fourteen-lncRNA risk score system for prognostic prediction of patients with non-small cell lung cancer

2020 ◽  
Vol 29 (4) ◽  
pp. 493-508
Author(s):  
Jia-Yi Song ◽  
Xiao-Ping Li ◽  
Xiu-Jiao Qin ◽  
Jing-Dong Zhang ◽  
Jian-Yu Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Small Cell Lung Cancer ◽  
Risk Score ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cox Regression Analysis ◽  
Score Model ◽  
Nsclc Patients

Growing evidence has underscored long non-coding RNAs (lncRNAs) serving as potential biomarkers for cancer prognosis. However, systematic tracking of a lncRNA signature for prognosis prediction in non-small cell lung cancer (NSCLC) has not been accomplished yet. Here, comprehensive analysis with differential gene expression analysis, univariate and multivariate Cox regression analysis based on The Cancer Genome Atlas (TCGA) database was performed to identify the lncRNA signature for prediction of the overall survival of NSCLC patients. A risk-score model based on a 14-lncRNA signature was identified, which could classify patients into high-risk and low-risk groups and show poor and improved outcomes, respectively. The receiver operating characteristic (ROC) curve revealed that the risk-score model has good performance with high AUC value. Multivariate Cox’s regression model and stratified analysis indicated that the risk-score was independent of other clinicopathological prognostic factors. Furthermore, the risk-score model was competent for the prediction of metastasis-free survival in NSCLC patients. Moreover, the risk-score model was applicable for prediction of the overall survival in the other 30 caner types of TCGA. Our study highlighted the significant implications of lncRNAs as prognostic predictors in NSCLC. We hope the lncRNA signature could contribute to personalized therapy decisions in the future.

Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC)

2019 ◽  
Vol 145 (9) ◽  
pp. 2285-2292 ◽  
Author(s):  
Jenny Hötzel ◽  
Nathaniel Melling ◽  
Julia Müller ◽  
Adam Polonski ◽  
Gerrit Wolters-Eisfeld ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Protein Expression ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Close Homologue

Overall Survival Analysis and Characterization of an EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) Population

2018 ◽  
Vol 54 (1) ◽  
pp. 10-17
Author(s):  
Filipa Aguiar ◽  
Gabriela Fernandes ◽  
Henrique Queiroga ◽  
José Carlos Machado ◽  
Luís Cirnes ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Survival Analysis ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Egfr Mutated ◽  
Overall Survival Analysis
Sign in / Sign up

Export Citation Format

Share Document