scholarly journals HMGA1 expression levels are elevated in pancreatic intraepithelial neoplasia cells in the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer

2017 ◽  
Vol 117 (5) ◽  
pp. 639-647 ◽  
Author(s):  
Michelle J Veite-Schmahl ◽  
William C Joesten ◽  
Michael A Kennedy
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Intraepithelial Neoplasia ◽  
Transgenic Mouse Model ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Expression Levels ◽  
Hmga1 Expression

scholarly journals NMR-based metabolic profiling of urine, serum, fecal, and pancreatic tissue samples from the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200658 ◽  
Author(s):  
Michelle J. Schmahl ◽  
Daniel P. Regan ◽  
Adam C. Rivers ◽  
William C. Joesten ◽  
Michael A. Kennedy
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Metabolic Profiling ◽  
Transgenic Mouse Model ◽  
Pancreatic Tissue ◽  
Tissue Samples ◽  
Urine Serum

scholarly journals Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model

Biology Open ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. bio052878
Author(s):  
Kavita Mallya ◽  
Dhanya Haridas ◽  
Parthasarathy Seshacharyulu ◽  
Ramesh Pothuraju ◽  
Wade M. Junker ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Model ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Intraepithelial Neoplasia ◽  
Ductal Adenocarcinoma ◽  
Chemotherapy Response ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Ductal Cells ◽  
Mucin Expression ◽  
Acinar To Ductal Metaplasia

ABSTRACTPancreatic cancer (PC) is acquired postnatally; to mimic this scenario, we developed an inducible KrasG12D; Ptf1a-CreER™ (iKC) mouse model, in which Kras is activated postnatally at week 16 upon tamoxifen (TAM) administration. Upon TAM treatment, iKC mice develop pancreatic intraepithelial neoplasia (PanIN) lesions and PC with metastasis at the fourth and fortieth weeks, respectively, and exhibited acinar-to-ductal metaplasia (ADM) and transdifferentiation. Kras activation upregulated the transcription factors Ncoa3, p-cJun and FoxM1, which in turn upregulated expression of transmembrane mucins (Muc1, Muc4 and Muc16) and secretory mucin (Muc5Ac). Interestingly, knockdown of KrasG12D in multiple PC cell lines resulted in downregulation of MUC1, MUC4, MUC5AC and MUC16. In addition, iKC mice exhibited ADM and transdifferentiation. Our results show that the iKC mouse more closely mimics human PC development and can be used to investigate pancreatic ductal adenocarcinoma (PDAC) biomarkers, early onset of PDAC, and ADM. The iKC model can also be used for preclinical strategies such as targeting mucin axis alone or in combination with neo-adjuvant, immunotherapeutic approaches and to monitor chemotherapy response.

scholarly journals Anticancer effects of Garcinol in pancreatic cancer transgenic mouse model

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Nadia Saadat ◽  
Sarah Akhtar ◽  
Aminder Gill ◽  
Nurul Razalli ◽  
Shilpa Vemuri ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Anticancer Effects

scholarly journals Effect of oil palm phenolics (OPP) on pancreatic cancer (PC) in transgenic mouse model (KPC)

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Shilpa Vemuri ◽  
Arvind Goja ◽  
Nadia Sadaat ◽  
Poornima Gowthaman ◽  
Michael Chrusciel ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Oil Palm ◽  
Transgenic Mouse Model ◽  
Oil Palm Phenolics
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