scholarly journals Contribution of mammography to MRI screening in BRCA mutation carriers by BRCA status and age: individual patient data meta-analysis

2016 ◽  
Vol 114 (6) ◽  
pp. 631-637 ◽  
Author(s):  
Xuan-Anh Phi ◽  
Sepideh Saadatmand ◽  
Geertruida H De Bock ◽  
Ellen Warner ◽  
Francesco Sardanelli ◽  
...  
Keyword(s):  
Individual Patient Data ◽  
Brca Mutation ◽  
Meta Analysis ◽  
Patient Data ◽  
Mutation Carriers ◽  
Brca Mutation Carriers

Endometrial Cancer in Germline BRCA Mutation Carriers: A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Emad Matanes ◽  
Alexander Volodarsky-Perel ◽  
Neta Eisenberg ◽  
Misgav Rottenstreich ◽  
Amber Yasmeen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Endometrial Cancer ◽  
Brca Mutation ◽  
Meta Analysis ◽  
Mutation Carriers ◽  
Brca Mutation Carriers ◽  
Germline Brca Mutation

scholarly journals OncotypeDX© Recurrence Score in BRCA mutation carriers: a systematic review and meta-analysis

2021 ◽  
Vol 154 ◽  
pp. 209-216
Author(s):  
Matthew G. Davey ◽  
Vinitha Richard ◽  
Aoife J. Lowery ◽  
Michael J. Kerin
Keyword(s):  
Systematic Review ◽  
Brca Mutation ◽  
Meta Analysis ◽  
Recurrence Score ◽  
Mutation Carriers ◽  
Brca Mutation Carriers

Endometrial cancer in germline BRCA mutation carriers: a systematic review and meta-analysis

2021 ◽  
Vol 162 ◽  
pp. S148-S149
Author(s):  
Emad Matanes ◽  
Susie Lau ◽  
Alexander Volodarsky-Perel ◽  
Neta Eisenberg ◽  
Cristina Mitric ◽  
...  
Keyword(s):  
Systematic Review ◽  
Endometrial Cancer ◽  
Brca Mutation ◽  
Meta Analysis ◽  
Mutation Carriers ◽  
Brca Mutation Carriers ◽  
Germline Brca Mutation

Magnetic Resonance Imaging Improves Breast Screening Sensitivity in BRCA Mutation Carriers Age ≥ 50 Years: Evidence From an Individual Patient Data Meta-Analysis

2015 ◽  
Vol 33 (4) ◽  
pp. 349-356 ◽  
Author(s):  
Xuan-Anh Phi ◽  
Nehmat Houssami ◽  
Inge-Marie Obdeijn ◽  
Ellen Warner ◽  
Francesco Sardanelli ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Breast Screening ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Random Effect ◽  
Patient Data ◽  
Resonance Imaging ◽  
Mutation Carriers ◽  
Screening Sensitivity

Purpose There is no consensus on whether magnetic resonance imaging (MRI) should be included in breast screening protocols for women with BRCA1/2 mutations age ≥ 50 years. Therefore, we investigated the evidence on age-related screening accuracy in women with BRCA1/2 mutations using individual patient data (IPD) meta-analysis. Patients and Methods IPD were pooled from six high-risk screening trials including women with BRCA1/2 mutations who had completed at least one screening round with both MRI and mammography. A generalized linear mixed model with repeated measurements and a random effect of studies estimated sensitivity and specificity of MRI, mammography, and the combination in all women and specifically in those age ≥ 50 years. Results Pooled analysis showed that in women age ≥ 50 years, screening sensitivity was not different from that in women age < 50 years, whereas screening specificity was. In women age ≥ 50 years, combining MRI and mammography significantly increased screening sensitivity compared with mammography alone (94.1%; 95% CI, 77.7% to 98.7% v 38.1%; 95% CI, 22.4% to 56.7%; P < .001). The combination was not significantly more sensitive than MRI alone (94.1%; 95% CI, 77.7% to 98.7% v 84.4%; 95% CI, 61.8% to 94.8%; P = .28). Combining MRI and mammography in women age ≥ 50 years resulted in sensitivity similar to that in women age < 50 years (94.1%; 95% CI, 77.7% to 98.7% v 93.2%; 95% CI, 79.3% to 98%; P = .79). Conclusion Addition of MRI to mammography for screening BRCA1/2 mutation carriers age ≥ 50 years improves screening sensitivity by a magnitude similar to that observed in younger women. Limiting screening MRI in BRCA1/2 carriers age ≥ 50 years should be reconsidered.

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