scholarly journals Assessing the impact of an English national initiative for early cancer diagnosis in primary care

2015 ◽  
Vol 112 (S1) ◽  
pp. S57-S64 ◽  
Author(s):  
G Rubin ◽  
C Gildea ◽  
S Wild ◽  
J Shelton ◽  
I Ablett-Spence
Keyword(s):  
Primary Care ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Early Cancer Diagnosis ◽  
National Initiative ◽  
The Impact

scholarly journals Improving early cancer diagnosis in primary care

Prescriber ◽  
2020 ◽  
Vol 31 (9) ◽  
pp. 10-14
Author(s):  
Samuel W D Merriel ◽  
Willie Hamilton
Keyword(s):  
Primary Care ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Early Cancer Diagnosis

scholarly journals The Extraordinary Progress in Very Early Cancer Diagnosis and Personalized Therapy: The Role of Oncomarkers and Nanotechnology

2016 ◽  
Vol 2016 ◽  
pp. 1-18 ◽  
Author(s):  
Marialuigina Fruscella ◽  
Antonio Ponzetto ◽  
Annalisa Crema ◽  
Guido Carloni
Keyword(s):  
Cancer Diagnosis ◽  
Cancer Genomics ◽  
Tumor Imaging ◽  
Early Cancer ◽  
Basic Knowledge ◽  
Epigenetic Biomarkers ◽  
Early Cancer Diagnosis ◽  
Early Tumor ◽  
Cancer Diagnosis And Therapy ◽  
The Impact

The impact of nanotechnology on oncology is revolutionizing cancer diagnosis and therapy and largely improving prognosis. This is mainly due to clinical translation of the most recent findings in cancer research, that is, the application of bio- and nanotechnologies. Cancer genomics and early diagnostics are increasingly playing a key role in developing more precise targeted therapies for most human tumors. In the last decade, accumulation of basic knowledge has resulted in a tremendous breakthrough in this field. Nanooncology, through the discovery of new genetic and epigenetic biomarkers, has facilitated the development of more sensitive biosensors for early cancer detection and cutting-edge multifunctionalized nanoparticles for tumor imaging and targeting. In the near future, nanooncology is expected to enable a very early tumor diagnosis, combined with personalized therapeutic approaches.

scholarly journals Gene Expression Correlation for Cancer Diagnosis: A Pilot Study

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Binbing Ling ◽  
Lifeng Chen ◽  
Qiang Liu ◽  
Jian Yang
Keyword(s):  
Pilot Study ◽  
Cancer Progression ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Correlation Coefficients ◽  
Gene Expressions ◽  
Clinical Biomarkers ◽  
Biomolecular Networks ◽  
Early Cancer Diagnosis ◽  
Novel Strategy

Poor prognosis for late-stage, high-grade, and recurrent cancers has been motivating cancer researchers to search for more efficient biomarkers to identify the onset of cancer. Recent advances in constructing and dynamically analyzing biomolecular networks for different types of cancer have provided a promising novel strategy to detect tumorigenesis and metastasis. The observation of different biomolecular networks associated with normal and cancerous states led us to hypothesize that correlations for gene expressions could serve as valid indicators of early cancer development. In this pilot study, we tested our hypothesis by examining whether the mRNA expressions of three randomly selected cancer-related genesPIK3C3,PIM3, andPTENwere correlated during cancer progression and the correlation coefficients could be used for cancer diagnosis. Strong correlations(0.68≤r≤1.0)were observed betweenPIK3C3andPIM3in breast cancer, betweenPIK3C3andPTENin breast and ovary cancers, and betweenPIM3andPTENin breast, kidney, liver, and thyroid cancers during disease progression, implicating that the correlations for cancer network gene expressions could serve as a supplement to current clinical biomarkers, such as cancer antigens, for early cancer diagnosis.

Endoscopic Ultraviolet-Induced Autofluorescence Spectroscopy of the Esophagus: Tissue Characterization and Potential for Early Cancer Diagnosis

Endoscopy ◽  
2000 ◽  
Vol 32 (10) ◽  
pp. 756-765 ◽  
Author(s):  
G. Bourg-Heckly ◽  
J. Blais ◽  
J.-J. Padilla ◽  
O. Bourdon ◽  
J. Etienne ◽  
...  
Keyword(s):  
Cancer Diagnosis ◽  
Tissue Characterization ◽  
Early Cancer ◽  
Early Cancer Diagnosis ◽  
Autofluorescence Spectroscopy

Early Versus Late Computed Tomography and Nasal Endoscopy in the Diagnosis of Nasopharyngeal and Paranasal Sinus Malignancy

2019 ◽  
Vol 33 (4) ◽  
pp. 388-394 ◽  
Author(s):  
Michael J. Marino ◽  
Mei-Chin Hsieh ◽  
Eric L. Wu ◽  
Charles A. Riley ◽  
Xiao-Cheng Wu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Overall Survival ◽  
Relative Risk ◽  
Paranasal Sinus ◽  
Cancer Diagnosis ◽  
Clinical Utility ◽  
Early Cancer ◽  
Disease Stage ◽  
Nasal Endoscopy ◽  
Early Cancer Diagnosis

Background Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) may be associated with an increased risk of subsequent diagnosis of nasopharyngeal carcinoma (NPC) or paranasal sinus cancer (PSC) in elderly Americans. The clinical utility of this association remains uncertain. Objective To compare early computed tomography (CT) or nasal endoscopy (NE) with late diagnostic studies for the diagnosis of NPC or PSC in elderly Americans with CRS or AR. Methods The Surveillance, Epidemiology, and End Results (SEER)-Medicare database was queried from 2003 to 2011 and included 150 088 Medicare beneficiaries. Patients with a diagnosis of CRS or AR were examined for either NE or CT performed within 6 months of the exposure diagnosis. The risk of a cancer diagnosis was determined between the early and the late diagnostic groups. Results The relative risk of early cancer diagnosis with NE was 1.98 (95% confidence interval [CI], 1.60–2.43). The number needed to detect (NND) a case of cancer with NE was 503 (95% CI, 387–718). The relative risk of an early cancer diagnosis using CT was 3.40 (95% CI, 2.85–4.06) and NND was 221 (95% CI, 194–255). The stage of NPC or PSC for the late diagnostic group was not different from those with early NE ( P = .458) or CT ( P = .497). Overall survival was not different between diagnostic groups for NE ( P = .789) or CT ( P = .425). Conclusions Early NE or CT is associated with a higher likelihood of cancer diagnosis in elderly individuals with a diagnosis of CRS or AR. The clinical utility of this association is limited due to the low prevalence of these malignancies and lack of difference in disease stage and overall survival between diagnostic groups.

scholarly journals P747 Adherence to ECCO guidelines for cancer surveillance is associated to the detection of early cancer: A retrospective, single-centre, cohort study

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S598-S599
Author(s):  
T L PARIGI ◽  
G Roda PhD ◽  
M Allocca ◽  
F Furfaro ◽  
L Loy ◽  
...  
Keyword(s):  
Family History ◽  
Skin Cancer ◽  
Disease Duration ◽  
Early Cancer ◽  
Cancer Surveillance ◽  
Early Cancer Diagnosis ◽  
Increased Risk ◽  
Significant Difference ◽  
History Of ◽  
The Impact

Abstract Background Patients with inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD) are at increased risk of developing gastrointestinal (GI) malignancies. The aim of this study is to assess the risk of malignancies in IBD patients and the impact of cancer screening according to the ECCO guidelines in a tertiary referral centre. Methods We retrospectively analysed the electronic database of all IBD patients followed by the IBD Centre of Humanitas Research Hospital, Milan, from January 2010 to October 2019, and collected all new diagnoses of solid and haematological tumours since 2010. The annual standardised incidence rate (SIR), rate of mortality and early cancer diagnosis were calculated and a descriptive analysis of drug exposure, disease duration, family history of any cancer, smoking habits was made. Results We included 5239 patients, with a total 19820 patient-years follow-up. Eighty-four malignancies in 81 patients were retrieved, 71 were included in the final analysis (38 CD, 32 UC, 31 females). Average age at tumour diagnosis was 52.9 years (range 19–78). 64% of patients were former or active smokers, 31% had a family history of cancer or IBD. Sixty-two per cent of patients were previously exposed or had 5-ASA at the time of cancer, 40% azathioprine, 43% anti-TNF or vedolizumab. The annual SIR for all kinds of malignancy was 0.358%. GI malignancies were the most frequent (n = 17, 23.9%, 47% UC, 53% in CD). Six over 8 GI tract malignancies in UC patients were found in the colon or rectum (mean disease duration 22.5 years), whereas in CD patients 5/9 were in the small-bowel (mean disease duration 7.0 years). Melanoma and breast cancer (n = 8 each) were the most common non-GI cancers, followed by prostate (n = 7) and bladder (n = 6). No significant difference in incidence was found between CD or UC. Non-Hodgkin lymphomas and leukaemia (3 and 1, respectively) only occurred in CD patients. Other tumours included thyroid (n = 5), lungs (n = 4), testicle (n = 3), ovary (n = 2), kidney (n = 2), head-nose-throat (n = 2), pancreas (n = 1), brain (n = 1), and non-melanoma skin cancer (n = 1). Death occurred in 11% of patients, 8 of them for late stage cancer. Only 2 were related to the concomitant IBD (1 colo-rectal and 1 anal cancer). In patients regularly screened according to the ECCO Guidelines (GI cancer, haematological and skin cancer), there was a significantly higher number of detection of early cancer (28 vs. 1, p = 0.003), although no differences in mortality rates were reported in the two groups (2 vs. 2, p = 0.10). Conclusion The overall incidence of cancer in our cohort was not different from the current literature available. Adherence to the ECCO Guidelines for cancer surveillance improves the detection of early cancer in IBD patients.

Spatial-temperature high resolution map for early cancer diagnosis

2009 ◽  
Author(s):  
Gheorghe V. Gavriloaia ◽  
Anca Hurduc ◽  
Ana-Maria Ghimigean ◽  
Radu Fumarel
Keyword(s):  
High Resolution ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Early Cancer Diagnosis ◽  
High Resolution Map ◽  
Spatial Temperature ◽  
Resolution Map

scholarly journals Oral brush biopsy analysis by MALDI-ToF Mass Spectrometry for early cancer diagnosis

Oral Oncology ◽  
2013 ◽  
Vol 49 (2) ◽  
pp. 152-156 ◽  
Author(s):  
Katja Maurer ◽  
Klaus Eschrich ◽  
Wolfgang Schellenberger ◽  
Julia Bertolini ◽  
Stefan Rupf ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Brush Biopsy ◽  
Maldi Tof Mass Spectrometry ◽  
Maldi Tof ◽  
Early Cancer Diagnosis ◽  
Oral Brush Biopsy
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