scholarly journals Tumour biomechanical response to the vascular disrupting agent ZD6126 in vivo assessed by magnetic resonance elastography

2014 ◽  
Vol 110 (7) ◽  
pp. 1727-1732 ◽  
Author(s):  
J Li ◽  
Y Jamin ◽  
J K R Boult ◽  
C Cummings ◽  
J C Waterton ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Elastography ◽  
Vascular Disrupting Agent ◽  
Biomechanical Response ◽  
Vascular Disrupting

scholarly journals The Response of RIF-1 Fibrosarcomas to the Vascular-Disrupting Agent ZD6126 Assessed by In Vivo and Ex Vivo1H Magnetic Resonance Spectroscopy

Neoplasia ◽  
2006 ◽  
Vol 8 (7) ◽  
pp. 560-567 ◽  
Author(s):  
Basetti Madhu ◽  
John C. Waterton ◽  
John R. Griffiths ◽  
Anderson J. Ryan ◽  
Simon P. Robinson
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Vascular Disrupting Agent ◽  
Vascular Disrupting

scholarly journals In-vivo waveguide cardiac magnetic resonance elastography

2015 ◽  
Vol 17 (S1) ◽  
Author(s):  
Ria Mazumder ◽  
Bradley D Clymer ◽  
Richard D White ◽  
Anthony Romano ◽  
Arunark Kolipaka
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Elastography

Magnetic Resonance Elastography for the Measurement of Annulus Fibrosus Material Properties

2011 ◽  
Author(s):  
Daniel H. Cortes ◽  
Lachlan J. Smith ◽  
Sung M. Moon ◽  
Jeremy F. Magland ◽  
Alexander C. Wright ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Magnetic Resonance ◽  
Shear Modulus ◽  
Disc Degeneration ◽  
Annulus Fibrosus ◽  
Pulse Sequence ◽  
Imaging Techniques ◽  
Mechanical Vibration ◽  
Magnetic Resonance Elastography

Intervertebral disc degeneration is characterized by a progressive cascade of structural, biochemical and biomechanical changes affecting the annulus fibrosus (AF), nucleus pulposus (NP) and end plates (EP). These changes are considered to contribute to the onset of back pain. It has been shown that mechanical properties of the AF and NP change significantly with degeneration [1,2]. Therefore, mechanical properties have the potential to serve as a biomarker for diagnosis of disc degeneration. Currently, disc degeneration is diagnosed based on the detection of structural and compositional changes using MRI, X-ray, discography and other imaging techniques. These methods, however, do not measure directly the mechanical properties of the extracellular matrix of the disc. Magnetic Resonance Elastography (MRE) is a technique that has been used to measure in vivo mechanical properties of soft tissue by applying a mechanical vibration and measuring displacements with a motion-sensitized MRI pulse sequence [3]. The mechanical properties (e.g., the shear modulus) are calculated from the displacement field using an inverse method. Since the applied displacements are in the order of few microns, fibers may not be stretched enough to remove crimping. Therefore, it is unknown if the anisotropy of the AF due to the contribution of the fibers is detectable using MRE. The objective of this study is twofold: to measure shear properties of AF in different orientations to determine the degree of AF anisotropy observable by MRE, and to identify the contribution of different AF constituents to the measured shear modulus by applying different biochemical treatments.

scholarly journals In vivo characterization of 3D skull and brain motion during dynamic head vibration using magnetic resonance elastography

2018 ◽  
Vol 80 (6) ◽  
pp. 2573-2585 ◽  
Author(s):  
Ziying Yin ◽  
Yi Sui ◽  
Joshua D. Trzasko ◽  
Phillip J. Rossman ◽  
Armando Manduca ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Elastography ◽  
Brain Motion ◽  
Dynamic Head ◽  
In Vivo Characterization

Determination of In-Vivo Elastic Properties of Soft Tissue Using Magnetic Resonance Elastography

2003 ◽  
Author(s):  
Francis E. Kennedy ◽  
Marvin M. Doyley ◽  
Elijah E. W. Van Houten ◽  
John B. Weaver ◽  
Keith D. Paulsen
Keyword(s):  
Magnetic Resonance ◽  
Soft Tissue ◽  
Elastic Properties ◽  
Magnetic Resonance Elastography ◽  
Tissue Properties ◽  
In Vivo Measurement ◽  
Ultrasonic Methods ◽  
Accurate Quantification

In-vivo measurement of the elastic properties of soft tissue have been made using a variety of direct techniques, such as indentation probes and rotary shear actuators, but they are unable to access much of the soft tissue of interest. Indirect ultrasonic methods for imaging elastic properties of soft tissue were first introduced about 15 years ago, see Ophir (1991). Although the results of ultrasonic elastography studies have been quite promising, they may not be suited for applications requiring accurate quantification of soft tissue properties. An alternative to ultrasound, magnetic resonance imaging, has the advantage of enabling precise measurement of all three components of tissue displacement. The reconstruction of elastic properties from the imaged displacement field is called magnetic resonance elastography (MRE), and is the subject of this paper.

In Vivo Determination of Hepatic Stiffness Using Steady-State Free Precession Magnetic Resonance Elastography

2006 ◽  
Vol 41 (12) ◽  
pp. 841-848 ◽  
Author(s):  
Dieter Klatt ◽  
Patrick Asbach ◽  
Jens Rump ◽  
Sebastian Papazoglou ◽  
Rajan Somasundaram ◽  
...  
Keyword(s):  
Steady State ◽  
Magnetic Resonance ◽  
Steady State Free Precession ◽  
Magnetic Resonance Elastography ◽  
Free Precession

In vivo multifrequency magnetic resonance elastography of the human intervertebral disk

2014 ◽  
Vol 74 (5) ◽  
pp. 1380-1387 ◽  
Author(s):  
Kaspar-Josche Streitberger ◽  
Gerd Diederichs ◽  
Jing Guo ◽  
Andreas Fehlner ◽  
Bernd Hamm ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Intervertebral Disk ◽  
Magnetic Resonance Elastography

scholarly journals Brain Stiffness Relates to Dynamic Balance Reactions in Children With Cerebral Palsy

2020 ◽  
Vol 35 (7) ◽  
pp. 463-471 ◽  
Author(s):  
Grace McIlvain ◽  
James B. Tracy ◽  
Charlotte A. Chaze ◽  
Drew A. Petersen ◽  
Gabrielle M. Villermaux ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Magnetic Resonance ◽  
Dynamic Balance ◽  
Superior Temporal Gyrus ◽  
Brain Regions ◽  
Magnetic Resonance Elastography ◽  
Neural Basis ◽  
Balance Impairment ◽  
Children With Cerebral Palsy

Cerebral palsy is a neurodevelopmental movement disorder that affects coordination and balance. Therapeutic treatments for balance deficiencies in this population primarily focus on the musculoskeletal system, whereas the neural basis of balance impairment is often overlooked. Magnetic resonance elastography (MRE) is an emerging technique that has the ability to sensitively assess microstructural brain health through in vivo measurements of neural tissue stiffness. Using magnetic resonance elastography, we have previously measured significantly softer grey matter in children with cerebral palsy as compared with typically developing children. To further allow magnetic resonance elastography to be a clinically useful tool in rehabilitation, we aim to understand how brain stiffness in children with cerebral palsy is related to dynamic balance reaction performance as measured through anterior and posterior single-stepping thresholds, defined as the standing perturbation magnitudes that elicit anterior or posterior recovery steps. We found that global brain stiffness is significantly correlated with posterior stepping thresholds ( P = .024) such that higher brain stiffness was related to better balance recovery. We further identified specific regions of the brain where stiffness was correlated with stepping thresholds, including the precentral and postcentral gyri, the precuneus and cuneus, and the superior temporal gyrus. Identifying brain regions affected in cerebral palsy and related to balance impairment can help inform rehabilitation strategies targeting neuroplasticity to improve motor function.

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