scholarly journals Estimating breast cancer mortality reduction and overdiagnosis due to screening for different strategies in the United Kingdom

2014 ◽  
Vol 110 (10) ◽  
pp. 2412-2419 ◽  
Author(s):  
N B Gunsoy ◽  
M Garcia-Closas ◽  
S M Moss
Keyword(s):  
Breast Cancer ◽  
United Kingdom ◽  
Cancer Mortality ◽  
Breast Cancer Mortality ◽  
Mortality Reduction ◽  
The United Kingdom

scholarly journals Survival of Patients with Breast Cancer Diagnosed in the United Kingdom Trial of Early Detection of Breast Cancer

1994 ◽  
Vol 1 (3) ◽  
pp. 193-198 ◽  
Author(s):  
S M Moss ◽  
R Ellman ◽  
D Coleman ◽  
J Chamberlain ◽  
Keyword(s):  
Breast Cancer ◽  
United Kingdom ◽  
Early Detection ◽  
Cancer Mortality ◽  
Tumour Size ◽  
Univariate Analysis ◽  
Breast Cancer Mortality ◽  
Randomised Trial ◽  
The United Kingdom ◽  
Significant Difference

To examine the survival of patients with breast cancer diagnosed in different centres and by different methods in the United Kingdom trial of early detection of breast cancer, in order to investigate the contribution of different factors to the previously observed reductions in breast cancer mortality. A non-randomised trial of the early detection of breast cancer, in which women aged 45–64 in two districts were offered annual screening for seven years, women in a further two districts were offered education about breast self examination (BSE), and those in four districts formed a comparison group. Patients with breast cancer are classified according to the type of centre, method of detection, and attendance for BSE education. Univariate and multivariate survival analyses are carried out, including tumour size, dissemination status, and use of adjuvant treatment as additional variables. In the univariate analysis, patients with breast cancer who are nonattenders for screening have a significantly worse prognosis than those in the comparison centres. Patients whose cancer is detected by mammography have the best survival rate. The inclusion of size and dissemination status in the multivariate analysis explains only about one third of the improved prognosis in these cases. There is a significant difference between prognosis in the two BSE centres. The use of prognostic factors as recorded in this trial to predict breast cancer mortality may be inadequate.

scholarly journals Trends in Breast Cancer Mortality Between 2001 and 2017: An Observational Study in the European Union and the United Kingdom

2021 ◽  
pp. 1682-1693
Author(s):  
Chinmay Jani ◽  
Ingrid Salcicciol ◽  
Arashdeep Rupal ◽  
Omar Al Omari ◽  
Richard Goodall ◽  
...  
Keyword(s):  
Breast Cancer ◽  
European Union ◽  
United Kingdom ◽  
Cancer Mortality ◽  
Breast Cancer Mortality ◽  
Mortality Rates ◽  
Percentage Change ◽  
Annual Percentage Change ◽  
The European Union ◽  
The United Kingdom

PURPOSE Breast cancer is the most common cancer in women worldwide, representing 25.4% of the newly diagnosed cases in 2018. The past two decades have seen advancements in screening technologies, guidelines, and newer modalities of treatment. Our study reports and compares trends in breast cancer mortality in the European Union and the United Kingdom. MATERIALS AND METHODS We used the WHO Mortality Database. We extracted breast cancer mortality data from 2001 to 2017 on the basis of the International Classification of Diseases, 10th revision system. Crude mortality rates were dichotomized by sex and reported by year. We computed age-standardized death rates (ASDRs) per 100,000 population using the world standard population. Breast cancer mortality trends were compared using joinpoint regression analysis. RESULTS We analyzed data from 24 EU countries, including the United Kingdom. For women, breast cancer mortality was observed to be downtrending in all countries except Croatia, France, and Poland. For the most recent female data, the highest ASDR for breast cancer was identified in Croatia (19.29 per 100,000), and the lowest ASDR was noted in Spain (12.8 per 100,000). Denmark had the highest change in ASDR and the highest estimated annual percentage change of −3.2%. For men, breast cancer mortality decreased in 18 countries, with the largest relative reduction observed in Denmark with an estimated annual percentage change of −27.5%. For the most recent male data, the highest ASDR for breast cancer was identified in Latvia (0.54 per 100,000). CONCLUSION Breast cancer mortality rates have down trended in most EU countries between 2001 and 2017 for both men and women. Given the observational nature of this study, causality to the observed trends cannot be reliably ascribed. However, possible contributing factors should be considered and subject to further study.

scholarly journals Effectiveness of service screening: a case–control study to assess breast cancer mortality reduction

2008 ◽  
Vol 99 (3) ◽  
pp. 423-427 ◽  
Author(s):  
D Puliti ◽  
◽  
G Miccinesi ◽  
N Collina ◽  
V De Lisi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Mortality ◽  
Case Control Study ◽  
Breast Cancer Mortality ◽  
Case Control ◽  
Mortality Reduction ◽  
Control Study
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