scholarly journals The effects of multidisciplinary rehabilitation: RePCa—a randomised study among primary prostate cancer patients

2013 ◽  
Vol 109 (12) ◽  
pp. 3005-3013 ◽  
Author(s):  
K B Dieperink ◽  
C Johansen ◽  
S Hansen ◽  
L Wagner ◽  
K K Andersen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Multidisciplinary Rehabilitation ◽  
Randomised Study ◽  
Primary Prostate Cancer

scholarly journals Insulin-like growth factor 1 receptor affects the survival of primary prostate cancer patients depending on TMPRSS2-ERG status

BMC Cancer ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Caterina Mancarella ◽  
Irene Casanova-Salas ◽  
Ana Calatrava ◽  
Maria García-Flores ◽  
Cecilia Garofalo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cancer Patients ◽  
Insulin Like Growth Factor ◽  
Primary Prostate Cancer

Abstract 2097: AI powered platform to identify primary prostate cancer patients with high risk of recurrence

2020 ◽  
Author(s):  
Wei Huang ◽  
Parag Jain ◽  
Raman Randhawa ◽  
Bijay Jaiswal ◽  
Samuel Hubbard ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Risk Of Recurrence ◽  
Primary Prostate Cancer

scholarly journals Kinetic modeling of 68Ga-PSMA-11 and validation of simplified methods for quantification in primary prostate cancer patients

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anna Ringheim ◽  
Guilherme de Carvalho Campos Neto ◽  
Udunna Anazodo ◽  
Lumeng Cui ◽  
Marcelo Livorsi da Cunha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Kinetic Modeling ◽  
Primary Prostate Cancer

scholarly journals Leptomeningeal Carcinomatosis of Metastatic Primary Prostate Cancer

2021 ◽  
pp. 753-760
Author(s):  
Daniel Stenberg ◽  
Megha Shalavadi ◽  
Humera Syeda ◽  
Krishna Reddy ◽  
Phillip Saunders
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Median Survival Time ◽  
Medical Literature ◽  
Leptomeningeal Carcinomatosis ◽  
Diagnostic Modality ◽  
Primary Prostate Cancer ◽  
Cerebral Involvement ◽  
Diagnostic Modalities ◽  
Uncommon Complication

Leptomeningeal carcinomatosis (LC) is an uncommon complication of cancer in which the disease metastasizes to the meninges; it is estimated that this occurs in 5% of cancer patients and is most often terminal. LC has a median survival time of approximately 15.7 weeks [Leal et al., Curr Cancer Ther Rev. 2011;7(4):319–27]. Furthermore, metastasis from the prostate is exceptionally rare with only a few cases described in medical literature. Until recently, leptomeningeal disruption was very rare and cerebral involvement was irrelevant [Bubendorf et al., Hum Pathol. 2000;31(5):578–83; Schaller et al., Br J Cancer. 2000;77(12):2386–9]. With improved imaging, diagnostic modalities, and treatment with therapies that do not cross the blood-brain barrier, the incidence of LC has been on the rise [Batool and Kasi, StatPearls, https://www.ncbi.nlm.nih.gov/books/NBK499862/]. Diagnosis previously relied on biopsy, supported by lumbar puncture findings. We submit a case demonstrating progressive and consistent evidence of LC found on imaging, justifying its acceptance as a diagnostic modality.

scholarly journals PSMA-Ligand Uptake Can Serve as a Novel Biomarker in Primary Prostate Cancer to Predict Outcome After Radical Prostatectomy

2021 ◽  
Author(s):  
Hui Wang ◽  
Thomas Amiel ◽  
Christoph Würnschimmel ◽  
Thomas Langbein ◽  
Katja Steiger ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Pet Imaging ◽  
Surgical Margin ◽  
Disease Outcome ◽  
Imaging Biomarker ◽  
Psma Ligand ◽  
Primary Prostate Cancer

Abstract BackgroundThe prostate-specific membrane antigen (PSMA) is a relevant target in prostate cancer and immunohistochemistry studies showed associations with outcome. PSMA-ligand positron emission tomography (PET) is increasingly used for primary prostate cancer staging and the molecular imaging TNM classification (miTNM) standardizes its reporting. We aimed to investigate the potential of PET-imaging to serve as a noninvasive imaging biomarker to predict disease outcome in primary prostate cancer after radical prostatectomy (RP).MethodsIn this retrospective analysis, 186 primary prostate cancer patients treated with RP who had undergone a 68Ga-PSMA-11 PET up to three months prior to the surgery were included. Maximum standardized uptake value (SUVmax), SUVmean, tumor volume (TV) and total lesion (TL) were collected from PET-imaging. Moreover, clinicopathological information, including age, serum prostate-specific antigen (PSA) level, and pathological characteristics were assessed for disease outcome prediction. A stage group system for PET-imaging findings based on the miTNM framework was developed. ResultsAt a median follow-up after RP of 38 months (interquartile range (IQR): 22-53), biochemical recurrence (BCR) was observed in 58 patients during the follow-up period. A significant association between a positive surgical margin and miN status (miN1 vs. miN0, odds ratio (OR): 5.428, p=0.004) was detected. miT status (miT≥3a vs. miT<3, OR: 2.696, p=0.003) was identified as an independent predictor for Gleason score (GS)≥8. Multivariate Cox regression analysis indicated that PSA level (hazard ratio (HR): 1.024, p=0.014), advanced GS (GS≥8 vs. GS<8, HR: 3.253, p<0.001) and miT status (miT≥3a vs. miT<3, HR: 1.941, p=0.035) were independent predictors for BCR. For stage I disease as determined by PET-imaging a shorter BCR-free survival was observed in the patients with higher SUVmax (IA vs. IB stage, log-rank, p=0.022).ConclusionPreoperative miTNM classification from 68Ga-PSMA-11 PET correlates with postoperative GS, surgical margin status and time to BCR. The association between miTNM staging and outcome proposes 68Ga-PSMA-11 PET as a novel non-invasive imaging biomarker and potentially serves for ancillary pre-treatment stratification. Prospective studies with larger cohort are necessary to fully determine its use including primary prostate cancer patients with different treatments and risk categories and late-stage patients.

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