scholarly journals MicroRNA profile: a promising ancillary tool for accurate renal cell tumour diagnosis

2013 ◽  
Vol 109 (10) ◽  
pp. 2646-2653 ◽  
Author(s):  
R M Silva-Santos ◽  
P Costa-Pinheiro ◽  
A Luis ◽  
L Antunes ◽  
F Lobo ◽  
...  
Keyword(s):  
Renal Cell ◽  
Cell Tumour ◽  
Tumour Diagnosis ◽  
Microrna Profile ◽  
Renal Cell Tumour

scholarly journals Renal cell tumour characteristics in patients with the Birt-Hogg-Dubé cancer susceptibility syndrome: a retrospective, multicentre study

2014 ◽  
Vol 9 (1) ◽  
Author(s):  
Patrick R Benusiglio ◽  
Sophie Giraud ◽  
Sophie Deveaux ◽  
Arnaud Méjean ◽  
Jean-Michel Correas ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Renal Cell ◽  
Cancer Susceptibility ◽  
Cell Tumour ◽  
Renal Cell Tumour ◽  
Tumour Characteristics

MicroRNA profile in stage I clear cell renal cell carcinoma predicts progression to metastatic disease

2020 ◽  
Vol 38 (10) ◽  
pp. 799.e11-799.e22 ◽  
Author(s):  
Matthew J. Moynihan ◽  
Travis B. Sullivan ◽  
Eric Burks ◽  
Jared Schober ◽  
Marc Calabrese ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Disease ◽  
Renal Cell ◽  
Clear Cell ◽  
Stage I ◽  
Cell Renal Cell Carcinoma ◽  
Microrna Profile

Testicular Sertoli cell tumour and potentially testicular Leydig cell tumour are features of DICER1 syndrome

2021 ◽  
pp. jmedgenet-2020-107434
Author(s):  
Lisa Golmard ◽  
Lauren M Vasta ◽  
Valérie Duflos ◽  
Carole Corsini ◽  
Catherine Dubois d'Enghien ◽  
...  
Keyword(s):  
Sertoli Cell ◽  
Leydig Cell ◽  
Autosomal Dominant ◽  
Pathogenic Variant ◽  
Cell Tumour ◽  
Malignant Tumours ◽  
Tumour Diagnosis ◽  
Sertoli Cell Tumour ◽  
Leydig Cell Tumour ◽  
Dicer1 Syndrome

DICER1 syndrome is a rare paediatric autosomal dominant inherited disorder predisposing to various benign and malignant tumours. It is caused by a germline pathogenic variant in DICER1, and the second hit for tumour development is usually a missense hotspot pathogenic variant in the DICER1 ribonuclease IIIb domain. While DICER1 predisposing variants account for about 60% of ovarian Sertoli-Leydig cell tumours, no DICER1-related testicular stromal tumours have been described. Here we report the first two cases of testicular stromal tumours in children carrying a DICER1 germline pathogenic variant: a case of Sertoli cell tumour and a case of Leydig cell tumour diagnosed at 2 and 12 years of age, respectively. A somatic DICER1 hotspot pathogenic variant was detected in the Sertoli cell tumour. This report extends the spectrum of DICER1-related tumours to include testicular Sertoli cell tumour and potentially testicular Leydig cell tumour. Diagnosis of a testicular Sertoli cell tumour should prompt DICER1 genetic testing so that patients with a DICER1 germline pathogenic variant can benefit from established surveillance guidelines. DICER1 genetic evaluation may be considered for testicular Leydig cell tumour. Our findings suggest that miRNA dysregulation underlies the aetiology of some testicular stromal tumours.

Primary Reninism: Hypertension, Hyperreninaemia and Secondary Aldosteronism Due to Juxtaglomerular Renal Cell Tumours

1973 ◽  
Vol 45 (s1) ◽  
pp. 279s-282s
Author(s):  
J. W. Conn ◽  
E. L. Cohen ◽  
W. J. McDonald ◽  
W. M. Blough ◽  
C. P. Lucas ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Cell ◽  
Renal Vein ◽  
Left Renal Vein ◽  
Cell Tumour ◽  
Renin Activity ◽  
Juxtaglomerular Cell ◽  
The Right ◽  
Renal Cell Tumours ◽  
Biochemical Abnormalities

1. A further case of renin-secreting renal juxtaglomerular cell tumour is reported. 2. Hypertension, aldosteronism and hypokalaemia were associated with high peripheral levels of renin. 3. Renin activity was twice as high in right as in left renal vein plasma. 4. A renal juxtaglomerular cell tumour was found in the right kidney and removed, after which the biochemical abnormalities and blood pressure were promptly corrected. 5. Explants of tumour tissue in culture produced large amounts of renin.

scholarly journals MP21-12 CAN A URINE MICRORNA PROFILE DISPLAY DIAGNOSTIC AND PROGNOSTIC VALUE FOR CLEAR CELL RENAL CELL CARCINOMA?

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Julia Oto ◽  
Mª José Solmoirago ◽  
José Vicente Sánchez-González* ◽  
Javier Pérez-Ardavin ◽  
Emma Plana ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Value ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Microrna Profile ◽  
Diagnostic And Prognostic Value
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