scholarly journals Critical weight loss is a major prognostic indicator for disease-specific survival in patients with head and neck cancer receiving radiotherapy

2013 ◽  
Vol 109 (5) ◽  
pp. 1093-1099 ◽  
Author(s):  
J A E Langius ◽  
S Bakker ◽  
D H F Rietveld ◽  
H M Kruizenga ◽  
J A Langendijk ◽  
...  
Keyword(s):  
Weight Loss ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Prognostic Indicator ◽  
Disease Specific Survival ◽  
Critical Weight ◽  
Disease Specific

Tumor-Infiltrating Lymphocytes in Patients With Advanced Laryngeal Cancer Undergoing Bioselection

2021 ◽  
pp. 019459982110137
Author(s):  
Molly E. Heft Neal ◽  
Joshua D. Smith ◽  
Andrew C. Birkeland ◽  
Catherine T. Haring ◽  
Steven B. Chinn ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Neck Cancer ◽  
Tertiary Care ◽  
Tumor Infiltrating Lymphocytes ◽  
Care Hospital ◽  
Disease Specific Survival ◽  
Infiltrating Lymphocytes ◽  
Disease Specific

Objective Bioselection to assess tumor response after induction chemotherapy has been introduced as an alternative treatment strategy to total laryngectomy for patients with advanced larynx squamous cell carcinoma (LSCC). Tumor-infiltrating lymphocytes (TILs) have proven to serve as prognostic biomarkers in head and neck cancer but have not been evaluated as a way to select patients for treatment paradigms. The aim of this study is to evaluate the role of pretreatment TILs in patients with advanced LSCC undergoing the bioselection paradigm. Study Design Retrospective study. Setting Tertiary care hospital. Methods Patients with advanced LSCC treated with bioselection and available tissue were included (N = 76). Patients were stratified into CD8-low and CD8-high cohorts by using the median TIL count. Kaplan-Meier survival analysis and multivariate cox regression were performed with SPSS version 26 (IBM). Results After controlling for tobacco use, tumor site, and stage, a high CD8 TIL count was an independent predictor of improved 5-year disease-specific survival (hazard ratio, 0.17 [95% CI, 0.03-0.84]; P = .03). CD8 TIL counts did not predict response to induction chemotherapy; however, subgroup analysis of patients treated with chemoradiation therapy revealed that CD8 TIL count was significantly associated with degree of response ( P = .012). Conclusion These findings support prior data published by our group showing that TILs are predictive of disease-specific survival in patients with head and neck cancer. CD8 TIL counts were significantly associated with degree of clinical response after induction chemotherapy. These results suggest that pretreatment assessment of tumor-infiltrating CD8 cells could be useful in selecting patients.

Prediction model to predict critical weight loss in patients with head and neck cancer during (chemo)radiotherapy

Oral Oncology ◽  
2016 ◽  
Vol 52 ◽  
pp. 91-96 ◽  
Author(s):  
Jacqueline A.E. Langius ◽  
Jos Twisk ◽  
Martine Kampman ◽  
Patricia Doornaert ◽  
Mark H.H. Kramer ◽  
...  
Keyword(s):  
Weight Loss ◽  
Head And Neck Cancer ◽  
Prediction Model ◽  
Head And Neck ◽  
Neck Cancer ◽  
Critical Weight

Prediction of critical weight loss during radiation treatment in head and neck cancer patients is dependent on BMI

2015 ◽  
Vol 24 (5) ◽  
pp. 2101-2109 ◽  
Author(s):  
Simon Lønbro ◽  
Gry Bjerg Petersen ◽  
Jens Rikardt Andersen ◽  
Jørgen Johansen
Keyword(s):  
Weight Loss ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Radiation Treatment ◽  
Critical Weight

scholarly journals Critical weight loss in head and neck cancer—prevalence and risk factors at diagnosis: an explorative study

2007 ◽  
Vol 15 (9) ◽  
pp. 1045-1050 ◽  
Author(s):  
Harriët Jager-Wittenaar ◽  
Pieter U. Dijkstra ◽  
Arjan Vissink ◽  
Bernard F. A. M. van der Laan ◽  
Rob P. van Oort ◽  
...  
Keyword(s):  
Risk Factors ◽  
Weight Loss ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cancer Prevalence ◽  
Critical Weight ◽  
Explorative Study

Effect of HPV-Associated p16INK4A Expression on Response to Radiotherapy and Survival in Squamous Cell Carcinoma of the Head and Neck

2009 ◽  
Vol 27 (12) ◽  
pp. 1992-1998 ◽  
Author(s):  
Pernille Lassen ◽  
Jesper G. Eriksen ◽  
Stephen Hamilton-Dutoit ◽  
Trine Tramm ◽  
Jan Alsner ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Treatment Response ◽  
Neck Cancer ◽  
Tumor Control ◽  
Disease Specific Survival ◽  
Conventional Radiotherapy ◽  
Locoregional Failure ◽  
Disease Specific

Purpose A subset of head and neck cancers is associated with the human papillomavirus (HPV). Viral infection is closely correlated with expression of p16INK4A in these tumors. We evaluated p16INK4A as a prognostic marker of treatment response and survival in a well-defined and prospectively collected cohort of patients treated solely with conventional radiotherapy in the Danish Head and Neck Cancer Group (DAHANCA) 5 trial. Patients and Methods Immunohistochemical expression of p16INK4A was analyzed in pretreatment paraffin-embedded tumor blocks from 156 patients treated with conventional primary radiotherapy alone. The influence of p16INK4A status on locoregional tumor control, disease-specific survival, and overall survival after radiotherapy was evaluated. Results p16INK4A positivity was found in 35 tumors (22%). Tumor-positivity for p16INK4A was significantly correlated with improved locoregional tumor control (5-year actuarial values 58% v 28%; P = .0005), improved disease-specific survival (72% v 34%; P = .0006), and improved overall survival (62% v 26%; P = .0003). In multivariate analysis, p16INK4A remained a strong independent prognostic factor for locoregional failure (hazard ratio [HR], 0.35; 95% CI, 0.19 to 0.64), disease-specific death (HR, 0.36; 95% CI, 0.20 to 0.64), and overall death (HR, 0.44; 95% CI, 0.28 to 0.68). Conclusion Expression of p16INK4A has a major impact on treatment response and survival in patients with head and neck cancer treated with conventional radiotherapy.

Salvage surgery in head and neck cancer: External validation of predictors of disease-specific survival

Oral Oncology ◽  
2020 ◽  
Vol 109 ◽  
pp. 104876
Author(s):  
Miquel Quer ◽  
Xavier León ◽  
Maria Casasayas ◽  
Aina Sansa ◽  
Montserrat López ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Salvage Surgery ◽  
External Validation ◽  
Disease Specific Survival ◽  
Disease Specific
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