scholarly journals Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer

2013 ◽  
Vol 108 (2) ◽  
pp. 278-284 ◽  
Author(s):  
R Bertorelle ◽  
M Briarava ◽  
E Rampazzo ◽  
L Biasini ◽  
M Agostini ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Prognostic Marker ◽  
Independent Prognostic Marker

scholarly journals Overexpression of SIX1 is an independent prognostic marker in stage I-III colorectal cancer

2015 ◽  
Vol 137 (9) ◽  
pp. 2104-2113 ◽  
Author(s):  
Christoph Kahlert ◽  
Tristan Lerbs ◽  
Mathieu Pecqueux ◽  
Esther Herpel ◽  
Michael Hoffmeister ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Marker ◽  
Stage I ◽  
Independent Prognostic Marker

scholarly journals Clinicopathologic and prognostic significance of LGR5, a cancer stem cell marker in patients with colorectal cancer

2019 ◽  
Vol 8 (4) ◽  
pp. CRC11 ◽  
Author(s):  
Chukwuemeka Ihemelandu ◽  
Aisha Naeem ◽  
Erika Parasido ◽  
Deborah Berry ◽  
Krysta Chaldekas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Prognostic Marker ◽  
Prognostic Significance ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Independent Prognostic Marker ◽  
Lgr5 Expression

Aim: To analyze the clinicopathologic and prognostic significance of Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a cancer stem cell marker expression in a cohort of colorectal cancer patients (CRC). Patients & methods: A total of 76 formalin-fixed paraffin-embedded tissue blocks of primary or metastatic tumors from 49 CRC patients were collected for duration 2009–2015. LGR5 expression was assessed through immunohistochemical staining of a tissue microarray. Results: LGR5 was significantly over expressed in CRC tissue samples and found to be a statistically significant independent prognostic marker for an improved overall survival. Conclusion: LGR5 expression was higher in colorectal cancer than in normal tissue. LGR5 was an independent prognostic marker for better clinical outcomes and might be used as a potential therapeutic target in CRCs.

scholarly journals Olfactomedin 4 (GW112, hGC-1) is an independent prognostic marker for survival in patients with colorectal cancer

2010 ◽  
Vol 1 (1) ◽  
pp. 73-78 ◽  
Author(s):  
NAOTSUGU SEKO ◽  
NAOHIDE OUE ◽  
TSUYOSHI NOGUCHI ◽  
KAZUHIRO SENTANI ◽  
NAOYA SAKAMOTO ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Marker ◽  
Independent Prognostic Marker

scholarly journals Cdc7 overexpression is an independent prognostic marker and a potential therapeutic target in colorectal cancer

2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Nathaniel Melling ◽  
Johanna Muth ◽  
Ronald Simon ◽  
Carsten Bokemeyer ◽  
Luigi Terracciano ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Marker ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
Independent Prognostic Marker

scholarly journals Serum oxidative stress is an independent prognostic marker in colorectal cancer

2019 ◽  
Vol 8 (5) ◽  
pp. 1699-1708 ◽  
Author(s):  
Kiichi Sugimoto ◽  
Kazuhiro Sakamoto ◽  
Masaya Kawai ◽  
Shingo Kawano ◽  
Shinya Munakata ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Colorectal Cancer ◽  
Prognostic Marker ◽  
Independent Prognostic Marker

scholarly journals Downregulation of B3GNT6 Predicts Poor Outcome in Colorectal Cancer Patients

2020 ◽  
Author(s):  
Chen Yang ◽  
Changhao Huang ◽  
Pengwei Zeng ◽  
Heyuan Huang ◽  
Zhikang Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Prognostic Marker ◽  
Protein Level ◽  
Mrna Level ◽  
The Cancer Genome Atlas ◽  
Cancer Tissue ◽  
Poor Overall Survival ◽  
Colorectal Cancer Patients

Abstract Background: B3GNT6 encodes the core 3 synthase in O-glycan biosynthesis. It is commonly expressed in the GI tract, while its clinical significance in colorectal cancer remains largely unknown.Methods: We gathered mRNA transcriptomic sequencing data from 3 Gene Expression Omnibus (GEO) datasets (GSE37182, GSE39582, GSE103512) and The Cancer Genome Atlas (TCGA) to compare the B3GNT6 mRNA level between colorectal cancer tissues and normal tissues and to evaluate its value as a prognostic marker. We further validated this in protein level using online database Human Protein Atlas and with immunohistochemical staining of B3GNT6 with our own cohort. Results: B3GNT6 expression was downregulated in colorectal cancer tissue compared with that in normal tissue in both mRNA and in protein level. Downregulation of B3GNT6 was associated with poor overall survival of colorectal cancer in GSE39582 and in TCGA database. Low B3GNT6 mRNA level was significantly associated with chromosome stable (CIN negative) and KRAS mutated group colorectal cancer patient. GSEA revealed that low B3GNT6 level in colorectal cancer is associated with upregulated proteasome activity.Conclusions: Downregulated B3GNT6 was correlated with poor overall survival of colorectal cancer patients. B3GNT6 could be used as a good prognostic marker in colorectal cancer.

scholarly journals MALDI-imaging reveals thymosin beta-4 as an independent prognostic marker for colorectal cancer

Oncotarget ◽  
2015 ◽  
Vol 6 (41) ◽  
pp. 43869-43880 ◽  
Author(s):  
Timo Gemoll ◽  
Sarah Strohkamp ◽  
Katharina Schillo ◽  
Christoph Thorns ◽  
Jens K. Habermann
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Marker ◽  
Maldi Imaging ◽  
Independent Prognostic Marker ◽  
Thymosin Beta 4
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