scholarly journals EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target

2011 ◽  
Vol 105 (3) ◽  
pp. 420-427 ◽  
Author(s):  
K Iida ◽  
K Nakayama ◽  
M T Rahman ◽  
M Rahman ◽  
M Ishikawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Outcomes ◽  
Gene Amplification ◽  
Squamous Cell ◽  
Therapeutic Target ◽  
Cervical Squamous Cell Carcinoma ◽  
Egfr Gene ◽  
Novel Therapeutic

scholarly journals Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma

2013 ◽  
Vol 43 (5) ◽  
pp. 1523-1530 ◽  
Author(s):  
JUNHYE KWON ◽  
TAE-SUP LEE ◽  
HAE WON LEE ◽  
MOON CHUL KANG ◽  
HYEON-JOON YOON ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Therapeutic Target ◽  
Integrin Alpha 6 ◽  
Novel Therapeutic

KLF5, a Novel Therapeutic Target in Squamous Cell Carcinoma

2021 ◽  
Vol 40 (12) ◽  
pp. 1503-1512
Author(s):  
Shuo Yang ◽  
Ting Feng ◽  
Hong Li
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Therapeutic Target ◽  
Novel Therapeutic

scholarly journals The MET Receptor Tyrosine Kinase Is a Potential Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma

2009 ◽  
Vol 69 (7) ◽  
pp. 3021-3031 ◽  
Author(s):  
Tanguy Y. Seiwert ◽  
Ramasamy Jagadeeswaran ◽  
Leonardo Faoro ◽  
Varalakshmi Janamanchi ◽  
Vidya Nallasura ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tyrosine Kinase ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Receptor Tyrosine Kinase ◽  
Therapeutic Target ◽  
Neck Squamous Cell Carcinoma ◽  
Met Receptor Tyrosine Kinase ◽  
Novel Therapeutic

scholarly journals Impact of RhoA overexpression on clinical outcomes in cervical squamous cell carcinoma treated with concurrent chemoradiotherapy

2020 ◽  
Vol 61 (2) ◽  
pp. 221-230
Author(s):  
Keiichi Tanaka ◽  
Yoshitaka Matsumoto ◽  
Hitoshi Ishikawa ◽  
Nobuyoshi Fukumitsu ◽  
Haruko Numajiri ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Squamous Cell ◽  
Distant Metastasis ◽  
Concurrent Chemoradiotherapy ◽  
Cervical Squamous Cell Carcinoma ◽  
Stage Ii ◽  
Free Survival

Abstract The Rho-associated coiled-coil-containing protein kinase (ROCK) pathway is known to influence metastasis in several cancers; however, the impact of the pathway on clinical outcomes in patients undergoing radiotherapy remains unknown. In the present study, the expression of RhoA, RhoC, ROCK-1, ROCK-2 and p53 was immunohistochemically evaluated using biopsy specimens obtained from 49 patients with stage II–III cervical squamous cell carcinoma treated with concurrent chemoradiotherapy (CCRT). The relationship between the expression of these proteins and patient outcomes was investigated. RhoA overexpression was associated with significantly impaired disease-free survival and distant metastasis-free survival (P = 0.045 and P = 0.041, respectively) in stage III cancer patients. No differences in survival were observed based on the expression of the other proteins among stage III cancer patients. In stage II cancer patients, no differences in survival were noted based on the expression of any of the proteins. The expression of RhoA was able to successfully differentiate cervical cancer patients with distant metastasis after CCRT. This information may help stratify patients according to the risk of metastasis, thereby leading to the potential to provide individualized treatment.

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