scholarly journals Insulin-like growth factor-binding protein-2 promotes prostate cancer cell growth via IGF-dependent or -independent mechanisms and reduces the efficacy of docetaxel

2011 ◽  
Vol 104 (10) ◽  
pp. 1587-1593 ◽  
Author(s):  
C C Uzoh ◽  
J M P Holly ◽  
K M Biernacka ◽  
R A Persad ◽  
A Bahl ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Cancer Cell Growth ◽  
Factor Binding

INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP5) SUPPORTS PROSTATE CANCER CELL PROLIFERATION

2009 ◽  
Vol 181 (4S) ◽  
pp. 186-186 ◽  
Author(s):  
Kiyoshi Takahara ◽  
Mototsugu Muramaki ◽  
Danbin Li ◽  
Michael E Cox ◽  
Martin E Gleave
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Growth Factor ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Binding Protein ◽  
Cancer Cell Proliferation ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Evidence that androgen-independent stromal growth factor signals promote androgen-insensitive prostate cancer cell growth in vivo

2009 ◽  
Vol 16 (2) ◽  
pp. 415-428 ◽  
Author(s):  
Kenichiro Ishii ◽  
Tetsuya Imamura ◽  
Kazuhiro Iguchi ◽  
Shigeki Arase ◽  
Yuko Yoshio ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Receptor Expression ◽  
Urogenital Sinus ◽  
Cancer Cell Growth ◽  
Androgen Ablation ◽  
Androgen Independent

Activation of tumor–stromal interactions is considered to play a critical role in the promotion of tumorigenesis. To discover new therapeutic targets for hormone-refractory prostate tumor growth under androgen ablation therapy, androgen-sensitive LNCaP cells and the derived sublines, E9 (androgen-low-sensitive), and AIDL (androgen-insensitive), were recombined with androgen-dependent embryonic rat urogenital sinus mesenchyme (UGM). Tumors of E9+UGM and AIDL+UGM were approximately three times as large as those of LNCaP+UGM. Tumors grown in castrated hosts exhibited reduced growth as compared with those in intact hosts. However, in castrated hosts, E9+UGM and AIDL+UGM tumors were still approximately twice as large as those of LNCaP+UGM. Cell proliferation in tumors of E9+UGM and AIDL+UGM grown in castrated host, was significantly higher than that in tumors of LNCaP+UGM. In vitro, expression of fibroblast growth factor (FGF)-2 and IGF-I, but not FGF-7 mRNA, was significantly reduced in UGM under androgen starvation. In cell culture, E9 cells were responsive to FGF-2 and FGF-7 stimulation, while AIDL responded to FGF-7 and IGF-1. Expression of FGFR1 and FGFR2 was considerably higher in E9 than those in LNCaP, similarly expression of FGFR2 and IGF-IR were elevated in AIDL. These data suggest that activation of prostate cancer cell growth through growth factor receptor expression may result in the activity of otherwise androgen-independent stromal growth factor signals such as FGF-7 under conditions of androgen ablation.

scholarly journals The methyl-CpG-binding protein MECP2 is required for prostate cancer cell growth

Oncogene ◽  
2005 ◽  
Vol 25 (9) ◽  
pp. 1358-1366 ◽  
Author(s):  
D Bernard ◽  
J Gil ◽  
P Dumont ◽  
S Rizzo ◽  
D Monté ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Binding Protein ◽  
Cancer Cell Growth ◽  
Protein Mecp2

scholarly journals PDLIM4, An Actin Binding Protein, Suppresses Prostate Cancer Cell Growth

2009 ◽  
Vol 27 (3) ◽  
pp. 264-272 ◽  
Author(s):  
Donkena Krishna Vanaja ◽  
Michael E. Grossmann ◽  
John C. Cheville ◽  
Mozammel H. Gazi ◽  
Aiyu Gong ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Binding Protein ◽  
Actin Binding ◽  
Cancer Cell Growth ◽  
Actin Binding Protein
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