scholarly journals Long-term clinical outcome of oestrogen receptor-positive operable primary breast cancer in older women: a large series from a single centre

2011 ◽  
Vol 104 (9) ◽  
pp. 1393-1400 ◽  
Author(s):  
B M Syed ◽  
W Al-Khyatt ◽  
S J Johnston ◽  
D W M Wong ◽  
L Winterbottom ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Older Women ◽  
Primary Breast Cancer ◽  
Oestrogen Receptor ◽  
Large Series ◽  
Single Centre

scholarly journals Oestrogen receptor negative early operable primary breast cancer in older women—Biological characteristics and long-term clinical outcome

PLoS ONE ◽  
2017 ◽  
Vol 12 (12) ◽  
pp. e0188528 ◽  
Author(s):  
Binafsha Manzoor Syed ◽  
DAL Morgan ◽  
Tulassi Setty ◽  
Andrew R. Green ◽  
Emma C. Paish ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Older Women ◽  
Primary Breast Cancer ◽  
Oestrogen Receptor ◽  
Biological Characteristics

scholarly journals Correction: Oestrogen receptor negative early operable primary breast cancer in older women—Biological characteristics and long-term clinical outcome

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0191979
Author(s):  
Binafsha Manzoor Syed ◽  
DAL Morgan ◽  
Tulassi Setty ◽  
Andrew R. Green ◽  
Emma C. Paish ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Older Women ◽  
Primary Breast Cancer ◽  
Oestrogen Receptor ◽  
Biological Characteristics

scholarly journals Long-term (37 years) clinical outcome of older women with early operable primary breast cancer managed in a dedicated clinic

2012 ◽  
Vol 23 (6) ◽  
pp. 1465-1471 ◽  
Author(s):  
B.M. Syed ◽  
S.J. Johnston ◽  
D.W.M. Wong ◽  
A.R. Green ◽  
L. Winterbottom ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Older Women ◽  
Primary Breast Cancer

scholarly journals Biological Characteristics and Clinical Outcome of Triple Negative Primary Breast Cancer in Older Women – Comparison with Their Younger Counterparts

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e100573 ◽  
Author(s):  
Binafsha M. Syed ◽  
Andrew R. Green ◽  
Christopher C. Nolan ◽  
David A. L. Morgan ◽  
Ian O. Ellis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Older Women ◽  
Primary Breast Cancer ◽  
Triple Negative ◽  
Biological Characteristics

scholarly journals Liver Kinase B1—A Potential Therapeutic Target in Hormone-Sensitive Breast Cancer in Older Women

Cancers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 149 ◽  
Author(s):  
Binafsha Manzoor Syed ◽  
Andrew R Green ◽  
David A L Morgan ◽  
Ian O Ellis ◽  
Kwok-Leung Cheung
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Clinical Outcome ◽  
Older Women ◽  
Therapeutic Target ◽  
Axillary Lymph Node ◽  
Tumour Size ◽  
Axillary Lymph ◽  
Liver Kinase B1

Background: The role of liver kinase B1 (LKB1), a serine/threonine kinase, has been described in the development of PeutzJagher’s syndrome, where a proportion (~45%) of patients have developed breast cancer in their lifetime. Cell line studies have linked LKB1 with oestrogen receptors (ER) and with the Adenosine monophosphate-activated protein kinase (AMPK) pathway for energy metabolism. However, limited studies have investigated protein expression of LKB1 in tumour tissues and its intracellular relationships. This study aimed to investigate the intracellular molecular relationships of LKB1 in older women with early operable primary breast cancer and its correlation with long-term clinical outcome. Methods: Between 1973 and 2010, a consecutive series of 1758 older (≥70 years) women with T0-2N0-1M0 breast carcinoma were managed in a dedicated facility. Of these, 813 patients underwent primary surgery, and 575 had good quality tumour samples available for tissue microarray construction. LKB1 was assessed in 407 cases by indirect immunohistochemistry (IHC). Tumours with 30% or more of cells with cytoplasmic LKB1 expression were considered positive. LKB1 expression was compared with tumour size, histological grade, axillary lymph node stage, ER, PgR, EGFR, HER2, HER3, HER4, BRCA1&2, p53, Ki67, Bcl2, Muc1, E-Cadherin, CD44, basal (CK5, CK5/6, CK14 and CK17) and luminal (CK7/8, CK18 and CK19) cytokeratins, MDM2 and MDM4, and correlated with long-term clinical outcome. Results: Positive LKB1 expression was seen in 318 (78.1%) patients, and was significantly associated with high tumour grade, high Ki67, over-expression of HER2, VEGF, HER4, BRCA2, MDM2 and negative expression of CD44 (p < 0.05). There was no significant correlation with tumour size, axillary lymph node status, ER, PgR, p53, basal or luminal cytokeratins, Bcl2, Muc1, EGFR, HER3, MDM4, E-cadherin and BRCA1. LKB1 did not show any significant influence on survival in the overall population; however, in those patients receiving adjuvant endocrine therapy for ER positive tumours, those with positive LKB1 had significantly better 5-year breast cancer specific survival when compared to those without such expression (93% versus 74%, p = 0.03). Conclusion: LKB1 expression has shown association with poor prognostic factors in older women with breast cancer. However, LKB1 expression appears to be associated with better survival outcome among those patients receiving adjuvant endocrine therapy. Further research is required to explore its potential role as a therapeutic target.

Early operable primary breast cancer in elderly (age 70 and older) women (EPC): Changing pattern of management and clinical outcome over 36 years.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 624-624
Author(s):  
S. J. Johnston ◽  
B. M. Syed ◽  
L. Winterbottom ◽  
H. Kennedy ◽  
D. A. Morgan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Older Women ◽  
Primary Breast Cancer ◽  
Elderly Age
Sign in / Sign up

Export Citation Format

Share Document