scholarly journals Characterization of soluble E-cadherin as a disease marker in gastric cancer patients

1998 ◽  
Vol 78 (8) ◽  
pp. 1095-1101 ◽  
Author(s):  
J Gofuku ◽  
H Shiozaki ◽  
Y Doki ◽  
M Inoue ◽  
M Hirao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Disease Marker ◽  
Gastric Cancer Patients ◽  
E Cadherin

Influence of age on soluble E-cadherin serum levels prevents its utility as a disease marker in gastric cancer patients

2008 ◽  
Vol 43 (6) ◽  
pp. 765-766 ◽  
Author(s):  
Corrado Pedrazzani ◽  
Stefano Caruso ◽  
Giovanni Corso ◽  
Daniele Marrelli ◽  
Alessandro Neri ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Serum Levels ◽  
Disease Marker ◽  
Gastric Cancer Patients ◽  
E Cadherin

scholarly journals Detection and Characterization of Metastatic Cancer Cells in the Mesogastrium of Gastric Cancer Patients

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142970 ◽  
Author(s):  
Daxing Xie ◽  
Liang Liu ◽  
Hasan Osaiweran ◽  
Chaoran Yu ◽  
Fang Sheng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Metastatic Cancer ◽  
Gastric Cancer Patients ◽  
Metastatic Cancer Cells

Abstract 3257: Molecular characterization of the human stomach microbiota in gastric cancer patients

2017 ◽  
Author(s):  
Guoqin Yu ◽  
Javier Torres ◽  
Nan Hu ◽  
Rafael Medrano-Guzman ◽  
Roberto Herrera-Goepfert ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Molecular Characterization ◽  
Human Stomach ◽  
Gastric Cancer Patients

scholarly journals E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients

2004 ◽  
Vol 40 (12) ◽  
pp. 1897-1903 ◽  
Author(s):  
Carla Oliveira ◽  
Paulo Ferreira ◽  
Sérgio Nabais ◽  
Luisa Campos ◽  
Ana Ferreira ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Genetic Predisposition ◽  
Germline Mutations ◽  
Gastric Cancer Patients ◽  
E Cadherin

Characterization of immune responses in gastric cancer patients: A possible impact of H. pylori to polarize a tumor-specific type 1 response?

2006 ◽  
Vol 120 (3) ◽  
pp. 285-296 ◽  
Author(s):  
Natasja K. van den Engel ◽  
Hauke Winter ◽  
Dominik Rüttinger ◽  
Irene Shau ◽  
Matthias Schiller ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Immune Responses ◽  
Cancer Patients ◽  
H Pylori ◽  
Gastric Cancer Patients

scholarly journals Molecular Characterization of the Human Stomach Microbiota in Gastric Cancer Patients

2017 ◽  
Vol 7 ◽  
Author(s):  
Guoqin Yu ◽  
Javier Torres ◽  
Nan Hu ◽  
Rafael Medrano-Guzman ◽  
Roberto Herrera-Goepfert ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Molecular Characterization ◽  
Human Stomach ◽  
Gastric Cancer Patients

scholarly journals Loss ofLLGL1Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Alexander Desuki ◽  
Frank Staib ◽  
Ines Gockel ◽  
Markus Moehler ◽  
Hauke Lang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Cell Lines ◽  
Gastric Cancer Cell ◽  
Cellular Adhesion ◽  
Peritoneal Metastases ◽  
Diffuse Gastric Cancer ◽  
Gastric Cancer Patients ◽  
E Cadherin

Background. Loss ofLLGL1has been associated with loss of cellular adhesion and dissemination of cells from colorectal cancer and malignant melanoma. Regulation and relevance ofLLGL1were analyzed in gastric cancer patients with lymphatic and distant dissemination. Furthermore,LLGL1expression was analyzed in relation to the cellular adhesion proteinE-cadherin.Methods.LLGL1andE-cadherintranscription levels were evaluated in 56 gastric cancer patients and five gastric cancer cell lines. IHC staining forLLGL1was performed on 39 gastric cancer specimens.LLGL1was stably transfected intoLLGL1negative gastric cancer cell line SNU16 (del(17) (p11.2)) for functionalin vitroassays and a xenograft bioassay.Results. Gastric cancer specimens and cell lines displayedLLGL1andE-cadherinexpression levels with variable intensity. In gastric mucosa,LLGL1exhibited weak cytoplasmic and strong cortical staining. Loss ofLLGL1expression occurred in 65% of gastric cancers and significantly correlated with loss ofE-cadherinexpression (P=0.00009). Loss ofLLGL1expression was associated with the diffuse type of gastric cancer (P=0.029) with peritoneal carcinomatosis (M1; P=0.006) and with female gender (P=0.017). Stable reexpression ofLLGL1in SNU16 cells significantly increased both plastic surface adhesion and extracellular matrix proteins laminin and fibronectin, but had no impact onin vitroproliferation, apoptosis, or invasion or onin vivoproliferation or differentiation in our xenograft bioassay.Conclusion.LLGL1is coexpressed withE-cadherin.Loss of expression of either protein is associated with diffuse gastric cancer and peritoneal metastases.LLGL1does not impact on proliferation or epithelial-mesenchymal transition (EMT) rather increasing cellular adhesion.

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